Dr. Wang's research interest focus is on breast cancer research, with a primary interest to understand the mechanism of genome stability and lineage plasticity in mammary epithelium. His current research projects include 1) the mechanism of the BRCA1/2 and its associated proteins to sustain genome integrity at active transcription sites; 2) the mechanisms of DNA damage induced by lineage plasticity in tumor initiation and progression; 3) identifying a new therapeutic vulnerability in BRCA or HRR-deficient cells.
Wang H*, Xiang D*, Liu B, He A, Randle HJ, Zhang KX, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178(1):135-51 e19. doi: 10.1016/j.cell.2019.06.002. PMCID: PMC6716369 (*Co-first author)
Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, et al. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1alpha activation. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(41):E9600-E9. doi: 10.1073/pnas.1807112115. PMCID: PMC6187201
Wang H*, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, et al. BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Molecular cell. 2016;63(2):277-92. doi: 10.1016/j.molcel.2016.05.038. PMCID: PMC4982517; (* Co-corresponding author)
Wang H, Teske D, Tess A, Kohlhepp R, Choi Y, Kendziorski C, et al. Identification of novel modifier loci of ApcMin affecting mammary tumor development. Cancer research. 2007;67(23):11226-33. doi: 10.1158/0008-5472.CAN-07-2487. PubMed PMID: 18056448