Jing Wen, PhD
Dr. Wen's research interest has been focused on immunotherapy and gene therapy for treatment of human immunodeficiency virus (HIV) infection, cancer, and central nervous system (CNS) diseases. Particularly, she has developed a delivery platform with effective blood-brain-barrier (BBB) penetration capability. This platform affords effectively delivery of monoclonal antibodies, nerve growth factors, and other therapeutic to the brain, opening a new avenue for treatment of CNS diseases, such as neuron degeneration, primary and metastatic brain tumors, spinal cord injury, and HIV CNS infection.
Jing Wen, Di Wu, Meng Qin, Chaoyong Liu, Lan Wang, Duo Xu, Harry V. Vinters, Yang Liu, Emiko Kranz, Yoojin Lee, Xin Guan, Guibo Sun, Xiaobo Sun, YooJin Lee, Otoniel Martinez-Maza, Daniel Widney, Yunfeng Lu, Irvin SY. Chen, Masakazu Kamata. (2019). Delivering therapeutic mAb to control cancer with CNS metastases. Nature Biomedical Engineering. 3(9), 706.
Di Wu, Meng Qin, Duo Xu, Lan Wang, Chaoyong Liu, Jie Ren, George Zhou, Chen Chen, Fengmei Yang, Yanyan Li, Yuan Zhao, Ruyi Huang, Sina Pourtaheri, Chunsheng Kang, Masakazu Kamata, Irvin SY Chen, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu. (2019). A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System. Advanced Materials. 31(18), 1807557. (Cover Feature)
Duo Xu, Di Wu, Meng Qin, Lina R. Nih, Chaoyong Liu, Zheng Cao, Jie Ren, Xiangjun Chen, Zhanlong He, Wenhai Yu, Jiaoqiong Guan, Suqin Duan, Fang Liu, Xiangsheng Liu, Jesse Li, Dushawn Harley, Bin Xu, Lihua Hou, Irvin S.Y. Chen, Jing Wen, Wei Chen, Sina Pourtaheri, Yunfeng Lu. (2019). Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration, Advanced Materials. 31 (33), 1900727 (Cover Feature)
Lei Han, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie Ren, Qixue Wang, Lixia Long, Yang Liu, Irvin Chen, Xubo Yuan, Yunfeng Lu, Chunsheng Kang. (2019). Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy, Advanced Materials. 31(19), 1805697. (Cover Feature)
Meng Qin, Lan Wang, Di Wu, Christopher K Williams, Duo Xu, Emiko Kranz, Qi Guo, Jiaoqiong Guan, Harry V. Vinters, YooJin Lee, Yiming Xie, Yun Luo, Guibo Sun, Xiaobo Sun, Zhanlong He, Yunfeng Lu, Masakazu Kamata, Jing Wen, Irvin S.Y. Chen. (2020). Enhanced Delivery of Rituximab into Brain and Lymph Nodes using Timed-Release Nanocapsules in Non-human Primates. Frontiers in Immunology.10,3132.