Dr. Joanna Schaenman's research is focused on immune control of infection with a focus on cytomegalovirus (CMV) and other viral infections that cause significant morbidity and mortality after transplantation. Another important area of study for her is the growing pool of elderly patients, where immunosuppression is associated with immunologic exhaustion and senescence, potentially important causes of increased infectious complications. In addition to direct cytopathic effects, viral infections may affect clinical outcomes by influencing immune reconstitution, graft-versus-host disease and development of rejection after solid organ transplantation.
Schaenman J, Khuu T, Kubak BM. Fungi as eukaryotes: Understanding the antifungal effects of immunosuppressive drugs. Curr Fungal Infect Rep 2014, Mar; 8 (1):102-8.
Arai S, Sahaf B, Narasimhan B, Chen GL, Jones CD, Lowsky R, Shizuru JA, Johnston LJ, Laport GG, Weng WK, Benjamin JE, Schaenman J, Brown J, Ramirez J, Zehnder JL, Negrin RS, Miklos DB. Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence. Blood. 2012 Jun 21;119(25):6145-54. doi: 10.1182/blood-2011-12-395970. Epub 2012 May 4.
Ho DY, Lin M, Schaenman J, Rosso F, Leung AN, Coutre SE, Sista RR, Montoya JG. Yield of diagnostic procedures for invasive fungal infections in neutropenic febrile patients with chest computed tomography abnormalities. Mycoses. 2011 Jan;54(1):59-70. doi: 10.1111/j.1439-0507.2009.01760.x.
Schaenman JM, Shashidhar S, Rhee C, Wong J, Navato S, Wong RM, Ho DY, Arai S, Johnston L, Brown JM. Early CMV viremia is associated with impaired viral control following nonmyeloablative hematopoietic cell transplantation with a total lymphoid irradiation and antithymocyte globulin preparative regimen. Biol Blood Marrow Transplant. 2011 May;17(5):693-702. doi: 10.1016/j.bbmt.2010.08.010. Epub 2010 Aug 22.
Kim JH, Schaenman JM, Ho DY, Brown JM. Treatment of acyclovir-resistant herpes simplex virus with continuous infusion of high-dose acyclovir in hematopoietic cell transplant patients. Biol Blood Marrow Transplant. 2011 Feb;17(2):259-64. doi: 10.1016/j.bbmt.2010.06.020. Epub 2010 Jul 6.