Kenneth Dorshkind, PhD
The goal of Dr. Ken Dorshkind's research program is the study of lymphocyte development from hematopoietic stem cells. A particular interest has been to determine how the growth and differentiation of lymphoid intermediates is regulated by cell intrinsic, tissue and systemic factors. His lab is currently focusing on two areas related to this main theme. One is to compare and contrast fetal and adult B cell development. This work has led to their identification of B-1 specified progenitors. The other current aim of the laboratory is to define the cellular and molecular changes that result in the age-related decline in lymphopoiesis.
Montecino-Rodriguez E, Fice M, Casero D, Berent-Maoz B, Barber CL, Dorshkind K. Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development. Immunity. 2016 Sep 20;45(3):527-39. doi: 10.1016/j.immuni.2016.07.012. Epub 2016 Aug 23.
Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013 Mar;123(3):958-65. doi: 10.1172/JCI64096. Epub 2013 Mar 1. Review.
Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14;119(24):5715-21. doi: 10.1182/blood-2011-12-400002. Epub 2012 May 3.
Montecino-Rodriguez E, Dorshkind K. B-1 B cell development in the fetus and adult. Immunity. 2012 Jan 27;36(1):13-21. doi: 10.1016/j.immuni.2011.11.017. Review.
Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15;22(22):3115-20. doi: 10.1101/gad.1715808.