Dr. Patel is a neurosurgeon-scientist with a research interest in optimizing surgical techniques for treatment of malignant brain tumors. He has studied standard and advanced (diffusion, perfusion, pH-weighted) magnetic resonance imaging techniques for visualization of infiltrating glioma cells and is currently in the process of beginning a clinical trial on pH based resections of glioblastoma. Furthermore, he has used single cell RNA sequencing and organoid cultures to study the drivers of growth and invasion in these infiltrating tumor cells, identifying druggable targets for use after pH based surgery.
Patel KS, Kejriwal S, Thammachantha S, et al. Increased epithelial membrane protein 2 expression in glioblastoma after treatment with bevacizumab. Neurooncol Adv. 2020;2(1):vdaa112. doi:10.1093/noajnl/vdaa112
Patel KS, Yao J, Raymond C, et al. Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma. Sci Rep. 2020;10(1):14819. doi:10.1038/s41598 020-71799-w
Patel KS, Everson RG, Yao J, et al. Diffusion Magnetic Resonance Imaging Phenotypes Predict Overall Survival Benefit From Bevacizumab or Surgery in Recurrent Glioblastoma With Large Tumor Burden. Neurosurgery. 2020;87(5):931-938. doi:10.1093/neuros/nyaa135
Patel KS, Kejriwal S, Sun MM, et al. Identification of epithelial membrane protein 2 (EMP2) as a molecular marker and correlate for angiogenesis in meningioma. J Neurooncol. 2020;147(1):15-24. doi:10.1007/s11060-020-03401-2