Dr. Van Savage's research is on the measurement and modeling of the vascular systems. He has written two papers and continued work on tumor angiogenesis, vascular structure, growth and drug delivery. A major component of his research is obtaining and analyzing vascular data from casts and angiography, including micro-CT, MRI, etc. By comparing and contrasting healthy and tumor vasculature in terms of scaling exponents and ratios, he gains insights into what shapes tumor vasculature and how tumors grow.
Johnson MG, Ennis D, Savage VM. Quantifying statistical self similarity in human vessel networks using data extracted automatically from MRI, PLoS Comput Biol 11(8), e1004455. [in press].
Savage VM, Herman AB, West GB, Leu K. Using Fractal Geometry and Universal Growth Curves as Diagnostics for Comparing Tumor Vasculature and Metabolic Rate With Healthy Tissue and for Predicting Responses to Drug Therapies. Discrete Continuous Dyn Syst Ser B. 2013 Jun;18(4). doi: 10.3934/dcdsb.2013.18.1077.
Herman AB, Savage VM, West GB. A quantitative theory of solid tumor growth, metabolic rate and vascularization. PLoS One. 2011;6(9):e22973. doi: 10.1371/journal.pone.0022973. Epub 2011 Sep 29.
Savage VM, Allen AP, Brown JH, Gillooly JF, Herman AB, Woodruff WH, West GB. Scaling of number, size, and metabolic rate of cells with body size in mammals. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4718-23. Epub 2007 Mar 1.
Savage VM, West GB. Biological scaling and physiological time: Biomedical applications. Complex System Science in Biomedicine. Ed. Deisboeck TS, Kresh JY. New York, Kluwer Academic. 2006.