Dr. Jonathan Said's research focuses on the pathologic basis of neoplastic disease.
Said's laboratory has a number of ongoing projects related to the use of tumor markers to characterize neoplastic proliferations. These include the use of immunohistochemistry and in situ hybridization to identify tumor antigens and gene products associated with neoplastic transformation and tumor progression.
Also under examination are mechanisms of lymphomagenesis, including the role of dendritic cells in the pathogenesis of lymphomas derived for germinal center lymphocytes and interfollicular proliferations.
Said and his colleagues are studying pathogenesis of HIV-related lymphoid proliferations. The laboratory, in association with the National Institute of Health-sponsored AIDS malignancy tumor bank, has accumulated a large bank of neoplastic tissue for evaluation of HIV-related neoplasia.
Cell cycle regulation in neoplastic proliferations is another focus for the researchers. The laboratory is evaluating a number of cyclins including cyclin A, cEBP, p15, p16, p21 and p27. Prostate and breast cancer cell lines are being evaluated for expression of cyclin genes and the effect of vitamin D and Vitamin D analogs on cellular proliferation, apoptosis and differentiation.
Finally, the laboratory is actively evaluating the roles of viruses, including the identified Kaposi's sarcoma associated herpesvirus, in the pathogenesis of neoplastic disease, including Kaposi's sarcoma, lymphoma and plasma cell dyscrasias.
Lee DH, Qi J, Bradner JE, Said JW, Doan NB, Forscher C, Yang H, Koeffler HP. Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2014 Oct 11. doi: 10.1002/ijc.29269. [Epub ahead of print]
Parilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Kettterling RP, Knudson RA, Sidhu JS, His ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman ML. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014 Aug 28;124(9):1473-80. doi: 10.1182/blood-2014-04-571091. Epub 2014 Jun 3.
Morgan EA, Pihan GA, Said JW, Yu H, Pinkus JL, Dorfman DM, Rodig SJ, Pinkus GS. Profile of CD103 Expression in T-cell Neoplasms: Immunoreactivity Is Not Restricted to Enteropathy-associated T-cell Lymphoma. Am J Surg Pathol. 2014 Nov;38(11):1557-70. doi: 10.1097/PAS.0000000000000296.
James AW, Nguyen A, Said J, Genshaft S, Lassman CR, Teitell M. Splenic hamartomas in Alagille syndrome: case report and literature review. Fetal Pediatr Pathol. 2014 Aug;33(4):216-25. doi: 10.3109/15513815.2014.913748. Epub 2014 May 27.
Wu W, Doan N, Said J, Karunasiri D, Pullarkat ST. Strong expression of chemokine receptor CCR9 in diffuse large B-cell lymphoma and follicular lymphoma strongly correlates with gastrointestinal involvement. Hum Pathol. 2014 Jul;45(7):1451-8. doi: 10.1016/j.humpath.2014.02.021. Epub 2014 Mar 13.