Manish Butte, MD, PhD

Manish Butte, M.D., Ph.D.


Professor, Department of Pediatrics, Allergy/Immunology
Chief, Division of Allergy, Immunology and Rheumatology




Allergy and Immunology

Institutional Affiliation

UCLA Mattel Children's Hospital
Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica



Allergy and Immunology, Boston Children's Hospital, 2003 - 2006
Research Fellowship, Harvard Medical School, 2003 - 2008


Ph.D., University of California, San Francisco, 2000
M.D., Brown University School of Medicine, 1996


Pediatrics, Children's Hospital of Philadelphia, 2000 - 2003

Board Certifications

Allergy and Immunology, American Board of Allergy and Immunology, 2005, 2016
Pediatrics, American Board of Pediatrics, 2004, 2012

Contact Information

Scientific Interests

Dr. Manish Butte's lab studies the impact of mechanical forces on T-cells. They hypothesize that mechanosensing pathways in T-cells become active in stiff tumors and inhibit the ability of T-cells to enter and kill. Butte's lab has been studying the activity of engineered T-cells in tumors in mice using 2-photon intravital microscopy. They perturb the mechanical environment of tumors using therapeutic agents and modify T-cell mechanosensing pathways.

Highlighted Publications

Thauland TJ, Hu KH, Bruce MA, Butte MJ. Cytoskeletal Adaptivity Regulates T Cell Receptor Signaling. Science Signaling, 2017 Mar 7;10(469). doi: 10.1126/scisignal.aah3737.

Choi J, Fernandez R, Maecker HT, Butte MJ. Systems approach to uncover signaling networks in primary immunodeficiency diseases. J Allergy Clin Immunol. 2017 Apr 13. pii: S0091-6749(17)30586-9. doi: 10.1016/j.jaci.2017.03.025. [Epub ahead of print]

Hu KH, Butte MJ. T cell activation requires force generation. J Cell Biol. 2016 Jun 6;213(5):535-42. doi: 10.1083/jcb.201511053. Epub 2016 May 30.

Wang A, Vijayraghavan K, Solgaard O, Butte MJ. Fast Stiffness Mapping of Cells Using High-Bandwidth Atomic Force Microscopy. ACS Nano. 2016 Jan 26;10(1):257-64. doi: 10.1021/acsnano.5b03959. Epub 2015 Dec 15.

Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007 Jul;27(1):111-22. Epub 2007 Jul 12.