Manish Butte, MD, PhD

Manish Butte, MD, PhD

Allergy and Immunology
Accepting new patients
Primary Location
Westwood Pediatrics
200 Medical Plaza
Suite 265
Los Angeles, California 90095


Manish J. Butte, MD, PhD is the E. Richard Stiehm Endowed Chair and Professor with tenure in the Department of Pediatrics at UCLA, and Division Chief of Immunology, Allergy, and Rheumatology. He has a joint appointment in the Department of Microbiology, Immunology, and Molecular Genetics. He studied Physics and also earned his MD at Brown University. He then studied structural biology at UCSF and graduated with a PhD in Biophysics. Returning to clinical training, he completed a Pediatrics residency at the Children's Hospital of Philadelphia and a clinical fellowship in Allergy & Immunology at Boston Children's Hospital. He did post-doctoral research at Harvard and worked on T-cell inhibitory pathways and chemistry. He spent his junior faculty years at Stanford University (2009-2016) and moved to UCLA in late 2016.

Academic Office Location

UCLA Pediatrics / Immunology
10833 Le Conte Avenue
MDCC Building, Room 12-430
Los Angeles, CA 90095

Research Lab Location

CHS Building, 4th floor, room 46-100

Research Lab Shipments

Butte Lab @ UCLA
650 Charles E Young Dr. South
CHS Building, Room 46-100
Los Angeles CA, 90095

Clinical Interests

  • Immune Deficiencies in pediatric and adult patients
  • Recurrent/frequent infections in pediatric and adult patients
  • Genetic diagnosis of immune deficiencies for pediatric and adult patients
  • Immune globulin replacement for pediatric and adult patients with immunodeficiency
  • Monogenic, rare autoimmune diseases
  • Disseminated Valley fever (coccidioidomycosis)




Medical Board Certifications

Allergy and Immunology, American Board of Allergy and Immunology, 2005
Pediatrics, American Board of Pediatrics, 2004


Research Fellowship, Harvard Medical School, 2008
Allergy & Immunology, Boston Children's Hospital, Harvard Medical School, 2006


Pediatrics, Children's Hospital of Philadelphia, 2003


PhD, University of California, San Francisco, 2000
MD, Brown University School of Medicine, 1996


Hospital Affiliations

Areas of Focus

Genetic disorders
Complications of immune suppression
Immune deficiency
Severe combined immunodeficiency
Primary immunodeficiency
Autoimmune diseases



A major research focus of his lab is to study T cells, the coordinating cells of the immune response, with a specific focus on infections, autoimmunity, and cancer. This work has been funded by the NIH and NSF. The second major focus of his lab is in improving the diagnosis and treatment of patients with rare, genetic immune diseases (primary immunodeficiency or inborn errors of immunity). He cares for children and adults with rare diseases in his clinic, which is supported by Jeffrey Modell Foundation. He is a co-Investigator in the NIH-funded Undiagnosed Diseases Network. He is one of the founding co-directors of the California Center for Rare Diseases. Dr. Butte's lab has trained 8 PhD students (5 completed and 2 currently), 6 postdocs (5 completed, 1 currently), and mentored many undergraduate and graduate students. His lab has publised over 100 papers with over 19,000 citations.


  • Top Doctors, Los Angeles Magazine, 2023
  • American Society for Clinical Investigation, 2021
  • Fellow of the Clinical Immunology Society, 2021