UCLA conducts research for a wide range of medical disorders and offers patients opportunities to participate in research and clinical trials.
Visit our Office of Clinical Trials website for more information about clinical trials.
Below are some featured trials at UCLA. Click here for a PDF of these trials. You may also visit the links to the right for additional trials from our clinical departments.
Information for Participants (UCLA OHRPP)
Understanding Clinical Trials (ClinicalTrials.gov)
UCLA Cancer Trials (UCLA JCCC)
Link to Non-Cancer Trials at UCLA
This study seeks to determine if memoryenhancement training, stress management and reducing cardiovascular risk factors lead to improvements in cognitive abilities. Eligible participants will be asked to join a twice-weekly program over the course of three months. The program involves fitness and clinical assessments to measure physical health, physical training, cognitive assessment and training, nutritional counseling and coaching, and five activity-monitoring sessions. Usual lifestyle activity will be monitored remotely via Fitbit for three additional months prior to or following this program. Total involvement in the study will last six months and all visits will take place at UCLA or St. Monica Catholic Church in Santa Monica. Info: (310) 206-1319 or firstname.lastname@example.org.
The (A4) study is a three-year clinical trials for individuals 65 to 85 years old who have normal thinking and memory function but who may be at risk for developing Alzheimer’s disease (AD) in the future. The study is designed to evaluate the effectiveness, safety and tolerability of treating AD with an investigational anti-amyloid antibody drug. The overall goal of the A4 study is to test whether decreasing amyloid build-up — a protein associated with memory loss in some people — with the study’s investigational treatment can help slow memory loss. Participants will be randomly assigned to receive either the investigational drug or a placebo (inactive substance). Info: (310) 794-6191 or email@example.com.
This Phase III clinical trial aims to test whether monthly infusions of investigational drug crenezumab — an anti-amyloid antibody — can slow AD disease progression and memory loss. Participants will have a 50 percent chance of receiving the active study drug versus a placebo (inactive substance). The study lasts approximately two years, with 26 infusion visits and the possibility of an open-label extension (allowing all participants, include those on placebos, to take the active study drug) upon completion. Individuals between the ages of 50 and 85 with a diagnosis of mild cognitive impairment (prodromal AD) and mild dementia due to AD may be eligible to participate. Info: (310) 794-6191 or firstname.lastname@example.org.
Physical exercise has been shown to improve memory, including in the elderly. Drugs developed to stop the underlying disease processes that cause Alzheimer’s disease (AD) may not improve memory without efforts to stimulate brain function. The study will test the clinical benefits of curcumin, a safe and effective compound isolated from the turmeric root, which has been found to inhibit several potential disease pathways in AD. The study also will determine how the addition of a physical exercise program in individuals with earl memory problems may affect memory function or brain imaging and blood-based markers associated with AD. Info: (310) 478-3711 ext 48625 or (310) 478-3711 ext 42171 or VAMemoryResearch@gmail.com.
For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy or loss of interest and pleasure in normal activities, UCLA is conducting a 12-month research study comparing levomilnacipran (FETZIMA) to placebo (inactive substance) for treatment of geriatric depression. Individuals 60 years of age or older may qualify. A complete psychiatric evaluation, physical exam and one MRI scan are provided. Participants will be compensated up to $200 and parking will be reimbursed. Info: (310) 794-9523 or (310) 794-4619.
UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. The study will involve 4, 2 hour visits.Must be an E-Cigarette user, or a non-smoker. Monetary compensation provided. Info: (310) 825-3510 or email@example.com.
The primary objective of this study is to evaluate the efficacy of monthly doses of aducanumab — in comparison to placebo intervention — in slowing cognitive and functional impairment in participants who are between the ages of 50 and 85 with early Alzheimer’s disease (AD). The study also will compare the efficacy of monthly doses of aducanumab, compared with placebo, across several measures that track clinical progression of AD. Info: (310) 794-6191 or firstname.lastname@example.org.
The FIGARO-DKD study is a Phase III clinical trial seeking to prove that the oral medication finerenone can slow the progression of kidney disease in patients with diabetes. To qualify for the study, participants must be between 18 and 85 years old with type 2 diabetes and kidney disease. If a participant meets additional criteria requirements, and is chosen to be part of the study, he or she will be randomly assigned to either receive the active medication or a placebo (inactive substance). Research participants will receive free lab and urine assessments, electrocardiograms and more. Visits usually occur once every four months, and participants will be reimbursed $40 per visit for travel expenses. Info: (310) 954-2692 or email@example.com
For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy or loss of interest and pleasure in activities, UCLA is conducting a 12-month research study using an experimental combination of two drugs and a placebo (inactive substance). The study seeks participants 60 years of age and older who are not currently receiving any psychiatric treatment with medications. Medical and psychiatric evaluations and limited physical exams are provided as a part of the study. Participants will undergo PET and MRI scans. Evaluations and study medications are provided at no charge. Info: (310) 794-9523
UCLA researchers are seeking women with and without polycystic ovary syndrome (PCOS) who are Caucasian and non-Hispanic, between the ages of 18 and 35, have a body-mass index between 18.5 and 25 and have not used hormones (i.e., birth control pills or a Mirena IUD) for the past three months. Participants will receive extensive free medical testing, including blood-hormone measurements, diabetes screening and ovarian and fat assessments. A small amount of fat will be removed from the abdomen and blood will be drawn for research purposes. Only women with PCOS will take an oral pill that contains either the drug Flutamide or a placebo (inactive substance) for six complete 28-day cycles. The free medical testing will be repeated at the end of the study. Women without PCOS may earn up to $300 and women with PCOS may earn up to $840. Info: (310) 825-7301 or Health4Women@mednet.ucla.edu.
This research study seeks individuals with gum disease (periodontitis) to participate in a clinical study to evaluate the effectiveness of laser therapy in the non-surgical treatment of chronic periodontal disease. This study will last twelve months. All visits will take place at the UCLA School of Dentistry in Westwood at the Periodontics Clinic. Participants who meet study criteria will receive education, non-surgical treatment and radiographs at no cost and be asked to return for follow-up evaluations at 1, 3, 6, 9 and 12 months after treatment. Participants will be compensated $100 for completion of the 12 month study. Info: (310) 825-3795.
The Aftercare Research Program at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA provides free assessment and treatment for participants in clinical research studies designed to improve understanding of psychotic disorders and develop more effective treatments. An initial diagnostic interview will determine a patient’s eligibility. The study will include cognitive training, individual case management, group therapy and antipsychotic medication. Patients’ family members will be invited to join family psychoeducational meetings. Info: (310) 206-3142 or firstname.lastname@example.org or email@example.com or www.semel.ucla.edu/aftercare.
UCLA researchers are seeking women ages 18 to 55 to help understand brain activity changes associated with a chronic-pain condition called vulvodynia. Women who have been diagnosed with vulvodynia or vestibulodynia, or those with chronic pain around the opening of the vagina with or without intercourse, may be eligible to participate. Participation includes a pelvic exam, sensitivity testing, one small blood sample and one MRI scan. Volunteers can earn up to $210 for participating. Info: (310) 825-5255 or firstname.lastname@example.org.
UCLA is seeking participants 60 years of age or older who are on stable medications for depression and are suffering from depressive symptoms and lack of energy to participate in a six-month research study. The trial involves 12 weekly 60-minute sessions of either a health and education wellness class or a Tai-Chi class. Participants will undergo two functional MRI scans and a complete psychiatric evaluation. Participants will be compensated. Info: (310) 983-3375
The UCLA Longevity Center is studying the effects of pomegranate juice on memory. Volunteers between the ages of 50 and 75 are needed. The study will last one year and includes five visits to UCLA and $300 compensation for participation. Info: (310) 825-0545
Aspirin is a mainstay therapy for patients with atherosclerotic cardiovascular disease (ASCVD). To identify the optimal dose of aspirin for secondary prevention in patients with ASCVD, UCLA will participate in a pragmatic clinical trial in which 20,000 patients who are at high risk for ischemic events will be recruited and randomly assigned to receive an aspirin dose of 81 mg/day or 325 mg/day. The goals of the ADAPTABLE study include: 1) comparing the effectiveness of two different doses of aspirin, and 2) comparing the effects of aspirin in selected subgroups of patients (e.g., women vs. men, older vs. younger patients, racial minority patients vs. white patients, patients with vs. without diabetes, and patients with vs. without chronic kidney disease). Info: 310-794-8502 or email@example.com.
The Addictions Research Laboratory in the Department of Psychology at UCLA is looking for individuals, age 21 to 55, who smoke cigarettes and drink alcohol heavily to participate in a study investigating a combination of medications (varenicline and naltrexone) for heavy drinking smokers. This study involves taking medication for 14 weeks in addition to 12 in-person visits over 7 months. During these visits, you will be asked to complete questionnaires about your health and drinking and smoking habits. Participants will be compensated up to $320 for participation. Info: (310) 206-6756.
UCLA is seeking adults between the ages of 18 and 65 with a history of vestibular migraine (VM) – a recently recognized type of migraine headache that causes attacks of vertigo and dizziness – to participate in a research study. Participants will undergo an observation phase and a treatment phase. While in the study, participants will need to document how often they get VM and track five of their last episodes in a diary. The study includes up to three visits and $50 in compensation per visit. Info: (310) 206-8511