Research and Clinical Trials

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Young Women Survivors of Breast Cancer

Are you a young survivor of breast cancer? Would you like to consider participating in a research study that focuses on wellness after breast cancer? UCLA is conducting a study to examine two group programs for young breast cancer survivors: Mindfulness-meditation classes and Survivorship Education classes. We would like to compare these two group programs on how they meet the common needs of young survivors. Classes will meet for six weeks and are held at UCLA. We will also ask you to come to UCLA for three in-person appointments throughout the duration of the study. You may be eligible to participate if you were diagnosed with breast cancer before age 45 and are within 5 years of your diagnosis.
Info: (310) 825-25020

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Depression in Older Adults

For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy or loss of interest and pleasure in normal activities, UCLA is conducting a 12-month research study comparing levomilnacipran (FETZIMA) to placebo (inactive substance) for treatment of geriatric depression. Individuals 60 years of age or older may qualify. A complete psychiatric evaluation, physical exam and one MRI scan are provided. Participants will be compensated up to $200 and parking will be reimbursed. Info: (310) 794-9523 or (310) 794-4619.

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Late-life Depression

For those who are suffering from feelings of depression, sadness, hopelessness, memory loss, concentration difficulties, lack of energy, or loss of interest and pleasure in normal activities, UCLA is conducting a 12-week research study using an experimental combination of two drugs and a placebo (inactive substance). The study seeks participants 60 years of age and older who are not currently receiving any psychiatric treatment with medications. Medical and psychiatric evaluations and limited physical exams are provided as a part of the study. Participants will undergo PET and MRI scans. Evaluations and study medications are provided at no charge.
Info: (310) 794-9523

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Wellness for Older Adults: Health Education or Tai-Chi

UCLA is seeking participants 60 years of age or older who are on stable medications for depression and are suffering from depressive symptoms and lack of energy to participate in a six-month research study. The trial involves 12 weekly 60-minute sessions of either a health and education wellness class or a Tai-Chi class. Participants will undergo two functional MRI scans and a complete psychiatric evaluation. Participants will be compensated.
(310) 794-9523

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Vulvodynia Research

UCLA researchers are seeking women ages 18 to 55 to help understand brain activity changes associated with a chronic-pain condition called vulvodynia. Women who have been diagnosed with vulvodynia or vestibulodynia, or those with chronic pain around the opening of the vagina with or without intercourse, may be eligible to participate. Participation includes a pelvic exam, sensitivity testing, one small blood sample and one MRI scan. Volunteers can earn up to $210 for participating.
Info: (310) 825-5255 or uclaobgynresearch@mednet.ucla.edu.

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Effects of E-Cigarettes on Blood Vessel Function (4 visits)

UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. The study will involve 4, 2 hour visits. Must be an E-Cigarette user, or a non-smoker. Monetary compensation provided.
Info: (310) 825-3510 or kpeters@mednet.ucla.edu.

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Effects of E-Cigarettes on Blood Vessel Function (2 visits)

UCLA is seeking healthy men and women between the ages of 21-45 for a research study on the effect of E-cigarettes on blood vessel function. The study will involve 2, 2 hour visits. Must smoke tobacco cigarettes. Monetary compensation provided.
Info: (310) 825-3510 or kpeters@mednet.ucla.edu.

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Anti-amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) Study

The A4 study is a three-year clinical trial for individuals 65 to 85 years old who have normal thinking and memory function but who may be at risk for developing Alzheimer’s disease (AD) in the future. The study is designed to evaluate the effectiveness, safety and tolerability of treating AD with an investigational anti-amyloid antibody drug. The overall goal of the A4 study is to test whether decreasing amyloid build-up — a protein associated with memory loss in some people — with the study’s investigational treatment can help slow memory loss. Participants will be randomly assigned to receive either the investigational drug or a placebo (inactive substance).
Info: (310) 794-6191 or cossinalde@mednet.ucla.edu

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CREAD Study: A Study of Crenezumab in Participants with Prodromal to Mild Alzheimer’s Disease (AD)

This Phase III clinical trial aims to test whether monthly infusions of investigational drug crenezumab — an anti-amyloid antibody — can slow AD disease progression and memory loss. Participants will have a 50 percent chance of receiving the active study drug versus a placebo (inactive substance). The study lasts approximately two years, with 26 infusion visits and the possibility of an open-label extension (allowing all participants, include those on placebos, to take the active study drug) upon completion. Individuals between the ages of 50 and 85 with a diagnosis of mild cognitive impairment (prodromal AD) and mild dementia due to AD may be eligible to participate.
Info: (310) 794-6191 or cossinalde@mednet.ucla.edu

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Curcumin and Yoga Therapy for Those at Risk for Alzheimer’s Disease (AD)

Physical exercise has been shown to improve memory, including in the elderly. Drugs developed to stop the underlying disease processes that cause AD may not improve memory without efforts to stimulate brain function. This study will test the clinical benefits of curcumin, a safe and effective compound isolated from the turmeric root, which has been found to inhibit several potential AD pathways. The study will also examine how engaging individuals with earl memory problems in an exercise program may affect their memory function or the brain-imaging and blood-based markers associated with AD.
Info: (310) 478-3711 ext 48625 or (310) 478-3711 ext 42171 or VAMemoryResearch@gmail.com

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ENGAGE Study

The primary objective of this study is to evaluate the efficacy of monthly doses of aducanumab — in comparison to placebo intervention — in slowing cognitive and functional impairment in participants who are between the ages of 50 and 85 with early Alzheimer’s disease (AD). The study also will compare the efficacy of monthly doses of aducanumab, compared with placebo, across several measures that track clinical progression of AD. Info: (310) 794-6191 or cossinalde@mednet.ucla.edu.

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Pomegranate Juice Study

The UCLA Longevity Center is studying the effects of pomegranate juice on memory. Volunteers between the ages of 50 and 75 are needed. The study will last one year and includes five visits to UCLA and $300 compensation for participation.
Info: (310) 825-0545

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Vestibular Migrane Research Study

UCLA is seeking adults between the ages of 18 and 65 with a history of vestibular migraine (VM) – a recently recognized type of migraine headache that causes attacks of vertigo and dizziness – to participate in a research study. Participants will undergo an observation phase and a treatment phase. While in the study, participants will need to document how often they get VM and track five of their last episodes in a diary. The study includes up to three visits and $50 in compensation per visit.
Info: (310) 206-8511