Timothy F. Cloughesy, MD

Timothy Cloughesy, MD

Professor and Director, Department of Neurology, Neurological Services, Neuro-Oncology Program
Physician, Department of Neurology
Member, Brain Research Institute





Institutional Affiliation

Ronald Reagan UCLA Medical Center



Neurological Oncology, Memorial Sloan-Kettering Cancer Center, 1991 - 1992


Neurology, Maricopa Medical Center, 1987 - 1988


MD, Tulane University School of Medicine, 1987


Neurology, UCLA School of Medicine, 1988 - 1991

Board Certification

Neurology, American Board of Psychiatry and Neurology, 1993

Contact Information


(310) 825-5321 - Neuro-Oncology Program information
(310) 206-6909 - Neuro-Oncology Program new patient appointments and referral

Clinical Interests

Brain Tumor, Neuro Oncology

Scientific Interests

Dr. Timothy Cloughesy's research focuses on clinical trials in brain cancer using targeted molecular therapies with novel clinical trial design. He has developed a brain cancer bioinformatics database which combines clinical outcomes, imaging and molecular analysis to enhance translational research. His goal is to use molecular biology to provide individualized care for brain cancer patients.

Highlighted Publications

Vivanco I, Robins HI, Rohle D, Campos C, Grommes C, Nghiemphu PL, Kubek S, Oldrini B, Chheda MG, Yannuzzi N, Tao H, Zhu S, Iwanami A, Kuga D, Dang J, Pedraza A, Brennan CW, Heguy A, Liau LM, Lieberman F, Yung WK, Gilbert MR, Reardon DA, Drappatz J, Wen PY, Lamborn KR, Chang SM, Prados MD, Fine HA, Horvath S, Wu N, Lassman AB, Deangelis LM, Yong WH, Kuhn JG, Mischel PS, Mehta MP, Cloughesy TF, Mellinghoff IK. Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov. 2012 May;2(5):458-71. Epub 2012 Mar 31

Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009 Oct 1;27(28):4733-40. Epub 2009 Aug 31

Carlson MR, Pope WB, Horvath S, Braunstein JG, Nghiemphu P, Tso CL, Mellinghoff I, Lai A, Liau LM, Mischel PS, Dong J, Nelson SF, Cloughesy TF. Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2. Clin Cancer Res. 2007; 13(9): 2592-8.

Schiepers C, Chen W, Dahlbom M, Cloughesy T, Hoh CK, Huang SC. (18)F-fluorothymidine kinetics of malignant brain tumors. Eur J Nucl Med Mol Imaging. 2007; 34(7): 1003-11.

Tso CL, Shintaku P, Chen J, Liu Q, Liu J, Chen Z, Yoshimoto K, Mischel PS, Cloughesy TF, Liau LM, Nelson SF. Primary glioblastomas express mesenchymal stem-like properties. Mol Cancer Res. 2006; 4(9): 607-19.