Dr. Dechen Lin has a broad background in cancer genetics and biology, with specific training and expertise in functional genomic study and transcriptional regulation. The major focus of his work is identifying key genomic abnormalities in human malignancies and translating these findings into novel clinical managements. To facilitate this research, he has established genomic approaches such as deep sequencing and high-density SNP-array profiling. He has also developed functional genomic approaches, especially high-throughput siRNA library screen to identify actionable cancer defects. With these tools and biological studies, Lin has uncovered important genomic aberrations which promote malignant phenotypes, including gene amplifications, somatic mutations and genomic deletions.
Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP. CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling. Cancer Res. 2016 May 1;76(9):2687-97. doi: 10.1158/0008-5472.CAN-15-1572. Epub 2016 Mar 8.
Lin DC, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Cancer Res. 2015 May 1;75(9):1815-27. doi: 10.1158/0008-5472.CAN-14-1433. Epub 2015 Apr 15.
Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR, Koeffler HP. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 2014 May;46(5):467-73. doi: 10.1038/ng.2935. Epub 2014 Mar 30.
Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, Macary P, Oo MZ, Ha CS, Yang H, Ogawa S, Loh KS, Koeffler HP. The genomic landscape of nasopharyngeal carcinoma. Nat Genet. 2014 Aug;46(8):866-71. doi: 10.1038/ng.3006. Epub 2014 Jun 22.
Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6109-14. doi: 10.1073/pnas.1218206110. Epub 2013 Mar 27.