Gregory Donaldson, PhD

The Donaldson Lab focuses on interactions between the gut microbiome and epithelial cells. In particular, we are studying how homeostatic maintenance of this interface could be harnessed to prevent epithelial cancers. In the future, we hope our work can inform the design and deployment of microbiome-based therapies for cancer prevention.

Donaldson GP†, Reis GL, Saad M, Mamede I, Chen G, DelGaudio NL, Zhang D, Aydin B, Harrer CE, Castro TBR, Grivennikov S, Reis BS, Stadtmueller BM, Victora GD, Mucida D†. "Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A." Biorxiv (in press Nature) https://doi.org/10.1101/2023.10.06.561290

Yu LW, Tran A, Liang J, Özcan E, Fu YF, Reichmuth L, Lau KM, Phan M, Li JH, Paramo J, Espinoza A, O’Sullivan TE, Donaldson GP, Hsiao EY. "Microbial Induction of gut serotonin promotes regulatory dendritic cells and colon tumorigenesis." (in revision)