Chen Yuan Kam, PhD

Dr. Kam's group is interested in understanding the cellular mechanisms that underlie the pathogenesis of angiosarcoma, a rare form of soft tissue sarcoma that arises from the transformation of endothelial cells, the squamous cells that line the surface of all blood vessels. Leveraging a longitudinal imaging approach utilizing multiphoton microscopy paired with genetic mouse models of angiosarcoma, they aim at understanding the vascular remodeling dynamics and underlying cellular behaviors that lead to the development of this disease.

Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sola P, Solanas G, Bonjoch J, Marsh EM, Hirschi KK*, Greco V*. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 10; 186(11):2345-2360. *Co-corresponding authors.

Kam CY, Dubash AD, Sheikh F, Lampe PD, Green KJ. Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43. Journal of Cell Biology. 2018 Sep 3;217(9):3219- 3235.

Dubash AD*, Kam CY*, Aguado BA, Patel DM, Delmar M, Shea LD, Green KJ. Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. Journal of Cell Biology. 2016 Feb 15;212(4):425-38. *These authors contributed equally to this work.

Boyden LM, Kam CY, Hernández-Martín A, Zhou J, Craiglow BG, Sidbury R, Mathes EF, Maguiness SM, Crumrine DA, Williams ML, Hu R, Lifton RP, Elias PM, Green KJ, Choate KA. Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome. Human Molecular Genetics. 2016 Jan 15;25(2):348-57.