The research in Dr. Li's lab is focused on cell engineering. The ongoing cancer research projects in his lab include: (1)Development of cancer vaccine booster by promoting the formation of T memory stem cells (2) Development of artificial antigen presenting cells to enhance CAR-T cell expansion antigen presenting cells to enhance CAR-T cell expansion and (4) Local delivery of drugs for cancer therapy.
Majedi FS, Hasani-Sadrabadi MM, Thauland TJ, Keswani SG, Li S, Bouchard LS, Butte MJ. (2023). Systemic enhancement of antitumour immunity by peritumourally implanted immunomodulatory macroporous scaffolds. Nat Biomed Eng. 2023 Jan;7(1):56-71. doi: 10.1038/s41551-022-00977-0. Epub 2022 Dec 22. PMID: 36550304
Zarubova J, Hasani-Sadrabadi MM, Norris SCP, Majedi FS, Xiao C, Kasko AM, Li S. (2022) Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells. Small. 2022. Dec;18(50):e2203515. doi: 10.1002/smll.202203515. Epub 2022 Oct 28. PMID: 36307906
Hasani-Sadrabadi MM, Majedi FS, Miller ML, Thauland TJ, Bouchard LS, Li S, Butte MJ. (2020). Augmenting T-cell responses to tumors by in situ nanomanufacturing. Mater Horiz. 2020 Nov 1;7(11):3028-3033. doi: 10.1039/d0mh00755b. Epub 2020 Sep 29. PMID: 33343906
Majedi FS, Hasani-Sadrabadi MM, Thauland TJ, Li S, Bouchard LS, Butte MJ. (2020) T-cell activation is modulated by the 3D mechanical microenvironment. Biomaterials. 2020 Sep;252:120058. doi: 10.1016/j.biomaterials.2020.120058. Epub 2020 Apr 24. PMID: 32413594
Majedi FS, Hasani-Sadrabadi MM, Thauland TJ, Li S, Bouchard LS, Butte MJ. (2019). Augmentation of T-Cell Activation by Oscillatory Forces and Engineered Antigen-Presenting Cells. Nano Lett. 2019 Oct 9;19(10):6945-6954. doi: 10.1021/acs.nanolett.9b02252. Epub 2019 Sep 3. PMID: 31478664