Brigitte N. Gomperts, MD

Brigitte Gomperts, MD

Professor, Department of Pediatrics, Hematology/Oncology
Vice Chief of Research, Pediatric Hematology/Oncology

Specialty

Pediatric Hematology/Oncology

Institutional Affiliation

Ronald Reagan UCLA Medical Center

Languages

English

Education

Fellowship

Pediatric Hematology-Oncology, Washington University School of Medicine, 1999 - 2002

Internships

Pediatrics, Washington University School of Medicine, 1996
Internal Medicine, Johannesburg General Hospital, 1994

Degree

MD, University of the Witwatersrand Medical School, 1993

Residency

Pediatrics, Washington University School of Medicine, 1996 - 1999

Board Certifications

Pediatric Hematology/Oncology, American Board of Pediatrics, 2002, 2014
Pediatrics, American Board of Pediatrics, 2000, 2012

Contact Information

Phone

(310) 825-6708 - Pediatric Hematology/Oncology information
(310) 825-0867 - Pediatric Hematology/Oncology patient appointments
(310) 825-6185 - Pediatric Hematology/Oncology pediatric physician relations liaison

Scientific Interests

Dr. Brigitte Gomperts is a physician-scientist who has been a faculty member at UCLA for over 20 years. She is Professor of Pediatrics and Pulmonary Medicine and Associate Director for Translation for the UCLA Broad Stem Cell Research Center. She is also Co-Director of the Jonsson Comprehensive Cancer Center Cancer Stem Cell Biology Program and Vice Chief of Research for Pediatric Hematology-Oncology. Her lab studies repair and regeneration of the lungs, and how the normal repair mechanisms are altered in lung diseases. Her lab is particularly interested in translational research that will result in new therapies for diseases and one area of focus is on identifying how environmental exposures like wildfire smoke affect mucociliary clearance of the airways.
 

Highlighted Publications

Ooi AT, Gomperts BN. Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA. Clin Cancer Res. 2015 Jun 1;21(11):2440-4. doi: 10.1158/1078-0432.CCR-14-1209. Epub 2015 Apr 2.

Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014 May;7(5):487-95. doi: 10.1158/1940-6207.CAPR-13-0372. Epub 2014 Mar 11.

Paul MK, Bisht B, Darmawan DO, Chiou R, Ha VL, Wallace WD, Chon AT, Hegab AE, Grogan T, Elashoff DA, Alva-Ornelas JA, Gomperts BN. Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell. 2014 Aug 7;15(2):199-214. doi: 10.1016/j.stem.2014.05.009. Epub 2014 Jun 19.

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18946-51. doi: 10.1073/pnas.1220319110. Epub 2013 Oct 24.

Gomperts BN, Walser TC, Spira A, Dubinett SM. Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer Prev Res (Phila). 2013 Jan;6(1):4-7. doi: 10.1158/1940-6207.CAPR-12-0470. Epub 2012 Dec 11.