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The role of Pink1/Parkin in the intestinal epithelium

About

Brief Summary

The purpose of this study is to compare gut biopsies taken from Parkinson’s Disease (PD) patients with and without mutations in PINK1 and PRKN and healthy adults to find the differences in gut leakiness, gut inflammation and gut oxidative stress. We are hoping to improve our understanding of the role of the gut in PD, which may lead to new diagnostic tests and improved treatment.

Eligibility

• PINK1/PRKN PD patients o Adults between the ages of 30 and 75 with a clinical diagnosis of Parkinson’s Disease and a mutation in PINK1 or PRKN • PD controls o Adults between the ages of 30 and 75 with a clinical diagnosis of Parkinson’s Disease o If PD onset was before the age of 60, genetic testing for mutations in PINK1/PRKN is required • Healthy controls o Adults between the ages of 30 and 75

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Study Stats
Protocol No.
21-000133
Category
Gastroenterology
Contact
Melissa Arevalo
Location
  • UCLA Westwood