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• Infertility

  Infertility

  Infertility is a problem of the reproductive system. It impairs the body's ability to reproduce. It can be a problem in the female reproductive system, the male reproductive system, or a mix of the two.
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• LGBTQ Care
• Polycystic Ovarian Syndrome

  Polycystic Ovary Syndrome (PCOS)

  PCOS is a common hormone problem in women of childbearing age. Women with PCOS may not ovulate, and have abnormal hormone levels. They may experience missed or irregular periods, excess hair growth and weight gain around the belly.
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• Recurrent Pregnancy Loss

  Understanding Repeated Pregnancy Loss

  Repeated pregnancy loss is when you have three or more miscarriages in a row. This usually happens in the first trimester or early second trimester. Miscarriages are common. You have a 15% to 20% chance of your pregnancy ending in miscarriage.
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• Reproductive Endocrinology

• Polycystic Ovary Syndrome (PCOS)
• Oocyte development and assisted reproductive techniques (ART) Nonhuman primate models of PCOS
• Developmental programming of adult diseases

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Selected articles from the past 5 years:

1. Allemand MC, Phy JL, Foong SC, Dumesic DA, Session DR, Tummon IS. Diagnosis of polycystic ovaries by three-dimensional transvaginal ultrasound. Fertil Steril 2006;85:214-219.
2. Zhou R, Bird IM, Dumesic DA, Abbott DH. Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:6630-6637.
3. Foong SC, Abbott DH, Zschunke MA, Lesnick TG, Phy JL, Dumesic DA. Follicle luteinization in hyperandrogenic follicles of polycystic ovary syndrome (PCOS) patients undergoing gonadotropin therapy for in vitro fertilization J Clin Endocrinol Metab. 2006;91:2327-2333.
4. Abbott DH, Padmanabhan V and Dumesic DA. 2006 Contributions of androgen and estrogen to fetal programming of ovarian dysfunction. Reproductive Biology and Endocrinology 4:17.
5. Wood JR, Dumesic DA, Abbott DH, Strauss JF. Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis. J Clin Endocrinol Metab. 2007;92:705-713.
6. Dumesic DA, Lesnick TG, Abbott DH. Increased Adiposity Enhances Intrafollicular Estradiol levels in Normoandrogenic Ovulatory Women Receiving GnRH Analog/Recombinant Human FSH Therapy for In Vitro Fertilization. J Clin Endocrinol Metab 2007;92:1438-1441.
7. Zhou R, Bruns CM, Bird IM, Kemnitz JW, Goodfriend TL, Dumesic DA, Abbott DA. Pioglitazone improves insulin action and normalizes menstrual cycles in a nonhuman primate model of polycystic ovary syndrome. Reprod Toxicol 2007;23:438-448.
8. Dumesic DA, Abbott DH, Padmanabhan V. PCOS and its Developmental Origins. Rev Endocr Metab Disord 2007;8:127-141.
9. Michailidou Z, Jensen MD, Dumesic D, Chapman KE, Seckl JR, Walker BR, Morton NM. Omental fat 11ß-hydroxysteroid dehydrogenase type 1 correlates with fat cell size independently of obesity. Obesity 2007;15:1155-1163.
10. Bruns CM, Baum ST, Colman RJ, Dumesic DA, Eisner JR, Jensen MD, Whigham LD, Abbott DH Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome. Int J Obes 2007;31:1579-1585.
11. Votruba SB, Mattison RS, Dumesic DA, Koutsauri C, Jensen MD. Meal fatty acid uptake in visceral fat in women. Diabetes 2007;56:2589-2597.
12. Padmanabhan V, Veiga-Lopez A, Abbott D, Dumesic D. Developmental programming of ovarian dysfunction. New Concepts in Ovarian Endocrinology. 2007; 329-352.
13. Dumesic DA, Padmanabhan V, Abbott DH. Polycystic ovary syndrome and oocyte developmental competence. Obstet Gynecol Surv 2008;63(1):39-48.
14. Dumesic DA, Abbott DH. Implications of polycystic ovary syndrome on oocyte development. Semin Reprod Med 2008;26(1):53-61.
15. Koutsari C, Dumesic DA, Patterson BW, Votruba SB, Jensen MD. Plasma free fatty acid storage into subcutaneous and visceral adipose tissue in postabsorptive women. Diabetes 2008;57:1186-1194.
16. Abbott DH, Barnett DK, Levine JE, Padmanabhan V, Dumesic DA, Jacoris S, Tarantal AF. Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys. Biol Reprod. 2008, 79:154-163.
17. Abbott DH, Zhou R, Bird IM, Dumesic DA, Conley AJ. Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome. Endocr Dev 2008;13:145-58.
18. Steckler TL, Herkimer C, Dumesic D, Padmanabhan V. Developmental Programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity- implication to PCOS. Endocrinology 2009;150:1456-65.
19. Abbott DH, Tarantal AF, Dumesic DA. Fetal, Infant, Adolescent and Adult Phenotypes of Polycystic Ovary Syndrome in Prenatally Androgenized Female Rhesus Monkeys. Am J Primatol 2009;71:776-784.
20. Abbott DH, Dumesic DA. Fetal androgen excess provides a developmental origin for polycystic ovary syndrome. Expert Rev Obstet Gynecol 2009;4:1-7.
21. Dumesic DA, Lesnick TG, Stassart JP, Ball GD, Wong A, Abbott DH. Intrafollicular antimullerian hormone (AMH) levels predict follicle responsiveness to FSH in normoandrogenic ovulatory women undergoing GnRH analog/recombinant human FSH therapy for IVF-ET. Fertil Steril 2009;92:217-221.
22. Grant CS, Ingle JN, Suman VJ, Dumesic DA, Wickerham DL, Gelber RD, Flynn PJ, Weir LM, Intra M, Jones WO, Perez EA, Hartman LC. Menstrual cycle and surgical treatment of breast cancer: findings from the NCCTG N9431 study. J Clin Oncol 2009;27:3620-6.
23. Dumesic DA, Patankar M, Barnett D, Lesnick T, Hutcherson B, Abbott DH. Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys. Hum Reprod 2009;24:3188-95.
24. Wild RA, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, Lobo R, Norman RJ, Talbott E, Dumesic DA. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a position statement by the Androgen Excess & Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab 2010;95:2038-2049.
25. Abbott DH, Bruns CR, Barnett DK, Dunaif A, Dumesic DA, Goodfriend TL, Tarantal AF. Experimentally-induced gestational androgen excess disrupts glucoregulation and stimulates growth in fetal and neonatal female rhesus monkeys. Am J Physiol Endocrinol Metab. 2010;299(5):E741-51.
26. Chazenbalk GD, Bertolotto C, Heneidi S, Jumabay M, Trivax B, Aronowitz J, Yoshimura K, Simmons CF, Dumesic DA, Azziz R. Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem/progenitor cells and adipocytes: evidence of cell plasticity. Plos One 2011;6:e17834.
27. Goodarzi M, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 2011;7:219-231.
28. Azziz R, Dumesic DA, Goodarzi M. Polycystic Ovary Syndrome: an ancient disorder? J Clin Endocrinol Metab. Fertil Steril 2011;95:1544-1548.
29. Dumesic DA, Pasch LA. Hirsuitism: bother or burden? Developing a patient-centered management approach. In press.
30. Fauser BCJM, Tarlatzis B, rebar R, Legro R, Balen A, Carmina E, Chang J, Yildiz B, Laven J, Boivin J, Petraglia F, Wijeyeratne, Norman R, Dunaif A, Franks S, Wild R, Dumesic D, Barnhart. Consensus on womenÆs health aspects of polycystic ovary syndrome. The Amsterdam ESHRE/ASRM-sponsored 3rd PCOS consensus workshop group. In press

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