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Specialty:: Medicine, Cardiology / Cardiovascular Disease
Medicine, Interventional Cardiology
Department Affiliation:: Medicine
Hospital Affiliation:: Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
State License:: A108268
Phone:: 310-825-8816
Health Plans:: Accepted Plans

About Me

Dr. Nsair is the Director of the Heart Transplantation and Mechanical Circulatory Support Program at UCLA. As well, he is a member of the Interventional and structural program at UCLA. He received his MD from the University of Alberta, where he also completed his Internal Medicine residency and Cardiology fellowship. He received advanced training in Advanced Heart Failure and Interventional Cardiology at UCLA Medical Center and a post-doctoral fellowship in Regenerative Therapies. His research interests include cardiovascular regenerative and rejuvenation therapies, as well as advanced studies of mechanical circulatory support devices in cardiogenic shock and novel heart failure medical therapies.

Dr. Nsair has strong interest in sports medicine and extensive expertise in managing cardiovascular disease in patients of all athletic levels. As well he is a skilled proceduralist in coronary and structural heart interventions. Current research interest focuses on implantable and wearable technologies in heart failure patients and athletics. Furthermore, his research interest involves mechanical circulatory support in patients with advanced heart failure and cardiogenic shock. He is involved in multiple clinical and translational trials and is the PI for a basic and translational research lab.

Locations:

Primary Office
Cardiovascular Center
100 UCLA Medical Plaza
Suite 630
Los Angeles, California 90095

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Phone
310-825-8816

Secondary Office
Santa Clarita - Primary & Specialty Care
25775 McBean Parkway
Suite 202
Valencia, California 91355
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Phone
661-753-5461
Fax
61-753-5465

Links

uclahealth.org/heart
stemcell.ucla.edu/member/nsair
uclahealth.org/santa-clarita

Primary Office: Cardiovascular Center
Primary Address: 100 UCLA Medical Plaza
Suite 630
Los Angeles, California 90095
: Get Directions
: View Map
Phone: 310-825-8816
Secondary Office: Santa Clarita - Primary & Specialty Care
Secondary Address: 25775 McBean Parkway
Suite 202
Valencia, California 91355
: Get Directions
: View Map
Phone: 661-753-5461
Fax: 661-753-5465

Medical Board Certifications: Internal Medicine, American Board of Internal Medicine, 2013
Certification 2: Advanced Heart Failure and Transplant Cardiology, American Board of Internal Medicine, 2016
Certification 3: Cardiovascular Disease, American Board of Internal Medicine, 2014
Fellowship: Cardiology, University of Alberta Hospital, 2005-2008
Fellowship 2: UCLA School of Medicine, 2008-2010
Fellowship 3: Cardiology, UCLA School of Medicine, 2010-2011
Residency: Internal Medicine, University of Alberta Hospital, 2002-2005
Degree: University of Alberta Faculty of Medicine, MD, 2002

Interests

Angina
Angina Pectoris
Angina pectoris (or simply angina) is chest pain or discomfort that keeps coming back. It happens when some part of your heart doesn't get enough blood and oxygen. Angina can be a symptom of coronary artery disease (CAD).
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Atherosclerosis
Atherosclerosis
Atherosclerosis is a type of thickening or hardening of the arteries caused by a buildup of plaque in the inner lining of an artery. It can increase your risk of heart attack, stroke, and other circulatory conditions.
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Atrial Fibrillation
Cardiac Biopsy
Cardiac Catheterization
Cardiac Catheterization
In cardiac catheterization (often called cardiac cath), a very small hollow tube, or catheter, is advanced from a blood vessel in the groin or arm through the aorta into the heart. Once it is in place, several diagnostic and treatment procedures can be done using catheterization.
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Cardiomyopathy
Cardiomyopathy
Any disorder that affects the heart muscle is called a cardiomyopathy. Cardiomyopathy causes the heart to lose its ability to pump blood well. In some cases, the heart rhythm also becomes disturbed. This leads to arrhythmias (irregular heartbeats).
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Cholesterol
Cholesterol in the Blood
The cholesterol in your blood comes from the foods you eat and your liver. Your liver makes all of the cholesterol your body needs. It helps your body make cell membranes, many hormones, and vitamin D.
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Congestive Heart Failure
Heart Failure
When you have heart failure, the heart is not able to pump as well as it should. Blood and fluid may back up into the lungs (congestive heart failure), and some parts of the body don’t get enough oxygen-rich blood to work normally.
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Coronary Artery Disease
Coronary Heart Disease
A person with coronary heart disease has an accumulation of fatty deposits in the coronary arteries. These deposits narrow the arteries and can decrease or block the flow of blood to the heart.
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General Cardiology
Home Page - Cardiovascular Diseases
Cardiovascular diseases include coronary heart disease, stroke, high blood pressure, and rheumatic heart disease.
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Heart Transplant
Heart Transplant
A heart transplant is surgery to remove the diseased heart from a person and replace it with a healthy one from an organ donor. To remove the heart from the donor, two or more healthcare providers must declare the donor brain-dead.
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Heart Transplant After Surgery
Heart Transplant
A heart transplant is surgery to remove the diseased heart from a person and replace it with a healthy one from an organ donor. To remove the heart from the donor, two or more healthcare providers must declare the donor brain-dead.
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Heart Valve Disease
Heart Valve Diseases
Heart valves can malfunction on one of two ways: They can fail to close completely, allowing blood to flow backward, or they can become damaged, limiting blood flow. Your doctor may think you have heart valve disease if your heart sounds heard through a stethoscope are abnormal.
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Hypertension
High Blood Pressure/Hypertension
Blood pressure is the force of the blood pushing against the artery walls. The force is created with each heartbeat as blood is pumped from the heart into the blood vessels. Blood pressure is also affected by the size of the artery walls and how elastic they are. Each time the heart beats (contracts and relaxes), pressure is created inside the arteries. High blood pressure, or hypertension, increases the risk for coronary heart disease (heart attack) and stroke (brain attack).
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Ischemia (Heart)
Transthoracic Echocardiography
Transesophageal Echocardiogram
A transesophageal echocardiogram (TEE) uses echocardiography to assess how well the heart works. During the procedure, a transducer (like a microphone) is lowered into the esophagus. It sends out ultrasonic sound waves at a frequency too high to be heard. When the transducer is placed at certain locations and angles, the ultrasonic sound waves move through the skin and other body tissues to the heart tissues, where the waves bounce or "echo" off of the heart structures.
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Publications

Nsair A, Archer S, London B, Hashimoto K, Michelakis E “Selective Loss of Hypoxic Pulmonary Vasoconstriction in Swap Kv 1.1-1.5 Mice.” Am. J. Resp. Crit. Care Med. 2001 July,1-235.
Archer SL, Wu XC, Thebaud B, Nsair A, Bonnet S, Tyrrell B, McMurtry MS, Hashimoto K, Harry G, Michelakis ED “Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.” Circ. Res. 2004 Aug 6; 95(3): 308-18.
Michelakis ED, Rebeyka I, Wu X, Nsair A, Thebaud B, Hashimoto K, Dyck JR, Harmony A, Harry G, Barr A, Archer SL “O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.” Circ. Res. 2002 Sep; 91(6):478-86.
Michelakis ED, Hampl V, Nsair A, Wu X, Harry G, Haromy A, Gurtu R, Archer SL. “Diversity in mitochondrial function explains differences in vascular oxygen sensing.” Circ. Res. 2002 Jun; 90(12):1307-15.
Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED. “Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv 1.5.” FASEB J. 2001 Aug; 15(10):1801-3.
Michelakis ED, Weir EK, Wu X, Nsair A, Waite R, Hashimoto K, Puttagunta L, Knaus HG, Archer SL. “Potassium channels regulate tone in rat pulmonary veins.” Am J Physiol Lung Cell Mol Physiol. 2001 June; 280(6):L1138-47.
Schenke-Layland K, Stock UA, Nsair A, Xie J, Angelis E, Fonseca CG, Larbig R, Mahajan A, Shivkumar K, Fishbein MC, Maclellan WR. “Cardiomyopathy is associated with structuralremodeling of heart valve extracellular matrix.” Eur. Heart J. 2009 Sep;30(18):2254-65
Nsair A, Schenke-Layland K. Invited commentary. Ann. Thoracic Surg. 2009 Aug;88(2):513-4.
Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR. “Recapitulation of the embryonic cardiovascular progenitor cell niche.” Biomaterials. 2011 Apr;32(11):2748-56.
Nsair A, W.R. MacLellan “Induced Pluripotent Stem Cells for Regenerative Cardiovascular Therapies and Biomedical Discovery.” Adv. Drug Deliv. Rev. 2011 Apr 30;63(4-5):324-30.
Nsair A, Schenke-Layland K, Van Handel B, H. Mikkola, W.R. MacLellan “Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells.” PLoS ONE, Oct. 2012.
Votteler M, Carvajal Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K. “Elastogenesis at the onset of human cardiac valve development.”Development. 2013 May 1. PMID: 23637335.
Yagishita D, Ajijola OA, Vaseghi M, Nsair A, Zhou W, Yamakawa K, Tung R, Mahajan A, Shivkumar K. “Electrical homogenization of ventricular scar by application of collagenase: a novel strategy for arrhythmia therapy.” Circ Arrhythm Electrophysiol. 2013 Aug 1;6(4):776-83. doi: 10.1161/CIRCEP.113.000448.
Cheng RK, Depasquale EC, Deng MC, Nsair A, Horwich TB. “Obesity in heart failure: impact on survival and treatment modalities.” Expert Rev Cardiovasc Ther. 2013 Aug 14.
Sasikanth Adigopula, MD, Rey P. Vivo, MD, Eugene C. DePasquale, MD, Ali Nsair, MD, Mario C. Deng, MD, FESC “Management of ACCF/AHA Stage C Heart Failure.” Cardiol Clin. 2014 Feb;32(1):73-93.
Nsair A, Liem DA, Cadeiras M, Cheng RK, Allareddy M, Kwon M, Shemin R, Deng MC. “Molecular basis of recovering on mechanical circulatory support.” Heart Fail Clin. 2014 Jan;10(1 Suppl):S57-62.
Ling Wu, Carolina Bluguermann, Levon Kyupelyan, Brooke Latour, Stephanie Gonzalez, Saumya Shah, Zoran Galic, Sundi Ge, Yuhua Zhu, Frank A. Petrigliano, Ali Nsair, Santiago G. Miriuka, Xinmin Li, Karen M. Lyons, Gay M. Crooks, David R. McAllister, Ben Van Handel, John S. Adams, and Denis Evseenko “Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells.” Stem Cell Reports, Dec 12, 2013.

In The News: UCLA doctors remove man's heart, replace it with total artificial heart - Dec 2012
Awards: UCLA stem cell researchers receive more than $6 million in grants from state agency - Dec 2012

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Angina Pectoris

Atherosclerosis

Cardiac Catheterization

Cardiomyopathy

Cholesterol in the Blood

Heart Failure

Coronary Heart Disease

Home Page - Cardiovascular Diseases

Heart Transplant

Heart Transplant

Heart Valve Diseases

High Blood Pressure/Hypertension

Transesophageal Echocardiogram