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Specialty:: Medicine, Cardiology / Cardiovascular Disease
Medicine, Interventional Cardiology
Department Affiliation:: Medicine
Hospital Affiliation:: Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
State License:: A108268
Phone:: 310-825-8816
Health Plans:: Accepted Plans

About Me

Academic/Professional Title:

Director, Heart Transplantation and Mechanical Circulatory Support Program

Links

uclahealth.org/heart
stemcell.ucla.edu/member/nsair
uclahealth.org/santa-clarita

Primary Office: Cardiovascular Center
Primary Address: 100 UCLA Medical Plaza
Suite 630
Los Angeles, California 90095
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Phone: 310-825-8816
Secondary Office: Santa Clarita - Primary & Specialty Care
Secondary Address: 25775 McBean Parkway
Suite 202
Valencia, California 91355
: Get Directions
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Phone: 661-753-5461
Fax: 661-753-5465

Medical Board Certifications: Internal Medicine, American Board of Internal Medicine, 2013
Certification 2: Advanced Heart Failure and Transplant Cardiology, American Board of Internal Medicine, 2016
Certification 3: Cardiovascular Disease, American Board of Internal Medicine, 2014
Fellowship: Cardiology, University of Alberta Hospital, 2005-2008
Fellowship 2: UCLA School of Medicine, 2008-2010
Fellowship 3: Cardiology, UCLA School of Medicine, 2010-2011
Residency: Internal Medicine, University of Alberta Hospital, 2002-2005
Degree: University of Alberta Faculty of Medicine, MD, 2002

Interests

Angina
Atherosclerosis
Atrial Fibrillation
Cardiac Biopsy
Cardiac Catheterization
Cardiomyopathy
Cholesterol
Congestive Heart Failure
Coronary Artery Disease
General Cardiology
Heart Transplant
Heart Transplant After Surgery
Heart Valve Disease
Hypertension
Ischemia (Heart)
Transthoracic Echocardiography

Research Interests

Cardiovascular Regenerative Therapies
Ventricular Assist Devices
Clinical Stem Cell Trials
Tissue Engineering

Publications

Nsair A, Archer S, London B, Hashimoto K, Michelakis E “Selective Loss of Hypoxic Pulmonary Vasoconstriction in Swap Kv 1.1-1.5 Mice.” Am. J. Resp. Crit. Care Med. 2001 July,1-235.
Archer SL, Wu XC, Thebaud B, Nsair A, Bonnet S, Tyrrell B, McMurtry MS, Hashimoto K, Harry G, Michelakis ED “Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.” Circ. Res. 2004 Aug 6; 95(3): 308-18.
Michelakis ED, Rebeyka I, Wu X, Nsair A, Thebaud B, Hashimoto K, Dyck JR, Harmony A, Harry G, Barr A, Archer SL “O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.” Circ. Res. 2002 Sep; 91(6):478-86.
Michelakis ED, Hampl V, Nsair A, Wu X, Harry G, Haromy A, Gurtu R, Archer SL. “Diversity in mitochondrial function explains differences in vascular oxygen sensing.” Circ. Res. 2002 Jun; 90(12):1307-15.
Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED. “Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv 1.5.” FASEB J. 2001 Aug; 15(10):1801-3.
Michelakis ED, Weir EK, Wu X, Nsair A, Waite R, Hashimoto K, Puttagunta L, Knaus HG, Archer SL. “Potassium channels regulate tone in rat pulmonary veins.” Am J Physiol Lung Cell Mol Physiol. 2001 June; 280(6):L1138-47.
Schenke-Layland K, Stock UA, Nsair A, Xie J, Angelis E, Fonseca CG, Larbig R, Mahajan A, Shivkumar K, Fishbein MC, Maclellan WR. “Cardiomyopathy is associated with structuralremodeling of heart valve extracellular matrix.” Eur. Heart J. 2009 Sep;30(18):2254-65
Nsair A, Schenke-Layland K. Invited commentary. Ann. Thoracic Surg. 2009 Aug;88(2):513-4.
Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR. “Recapitulation of the embryonic cardiovascular progenitor cell niche.” Biomaterials. 2011 Apr;32(11):2748-56.
Nsair A, W.R. MacLellan “Induced Pluripotent Stem Cells for Regenerative Cardiovascular Therapies and Biomedical Discovery.” Adv. Drug Deliv. Rev. 2011 Apr 30;63(4-5):324-30.
Nsair A, Schenke-Layland K, Van Handel B, H. Mikkola, W.R. MacLellan “Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells.” PLoS ONE, Oct. 2012.
Votteler M, Carvajal Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K. “Elastogenesis at the onset of human cardiac valve development.”Development. 2013 May 1. PMID: 23637335.
Yagishita D, Ajijola OA, Vaseghi M, Nsair A, Zhou W, Yamakawa K, Tung R, Mahajan A, Shivkumar K. “Electrical homogenization of ventricular scar by application of collagenase: a novel strategy for arrhythmia therapy.” Circ Arrhythm Electrophysiol. 2013 Aug 1;6(4):776-83. doi: 10.1161/CIRCEP.113.000448.
Cheng RK, Depasquale EC, Deng MC, Nsair A, Horwich TB. “Obesity in heart failure: impact on survival and treatment modalities.” Expert Rev Cardiovasc Ther. 2013 Aug 14.
Sasikanth Adigopula, MD, Rey P. Vivo, MD, Eugene C. DePasquale, MD, Ali Nsair, MD, Mario C. Deng, MD, FESC “Management of ACCF/AHA Stage C Heart Failure.” Cardiol Clin. 2014 Feb;32(1):73-93.
Nsair A, Liem DA, Cadeiras M, Cheng RK, Allareddy M, Kwon M, Shemin R, Deng MC. “Molecular basis of recovering on mechanical circulatory support.” Heart Fail Clin. 2014 Jan;10(1 Suppl):S57-62.
Ling Wu, Carolina Bluguermann, Levon Kyupelyan, Brooke Latour, Stephanie Gonzalez, Saumya Shah, Zoran Galic, Sundi Ge, Yuhua Zhu, Frank A. Petrigliano, Ali Nsair, Santiago G. Miriuka, Xinmin Li, Karen M. Lyons, Gay M. Crooks, David R. McAllister, Ben Van Handel, John S. Adams, and Denis Evseenko “Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells.” Stem Cell Reports, Dec 12, 2013.

In The News: UCLA doctors remove man's heart, replace it with total artificial heart - Dec 2012
Awards: UCLA stem cell researchers receive more than $6 million in grants from state agency - Dec 2012

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