Analgesic and Subjective Effects of Terpenes

About

Brief Summary

The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.

Primary Purpose

Basic science

Study Type

Interventional

Phase

Phase 1

Gender

All

Healthy Volunteers

Yes

Minimum Age

21 Years

Maximum Age

55 Years

Male or non-pregnant female aged 21-55 years
Report non-medical use of cannabis 1-7 days per week over the 1 month prior to screening
Not currently seeking treatment for cannabis use
Urine test positive for recent cannabis use
Have a Body Mass Index from 18.5 - 34kg/m2.
Able to perform all study procedures
Must be using a contraceptive method (hormonal or barrier methods)

Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or mild CUD
Report using other illicit drugs in the prior 4 weeks
- If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures.
Current licit use of cannabis primarily for medical purposes, prescription analgesics, or any medications that may affect study outcomes
Current pain
Pregnancy is exclusionary due to the possible effects of the study medication on fetal development.
History of an allergic reaction or adverse reaction to cannabis is exclusionary.
History of respiratory illness or current respiratory illness
History of seizure disorder or current seizure disorder
Insensitivity to the cold water stimulus of the Cold Pressor Test
Currently enrolled in another research protocol
Current major Axis 1 disorders (mood, anxiety, or psychotic disorder)
Not using a contraceptive method (hormonal or barrier methods)
The evaluating physician reviews all medical assessments along with medical history. Any disorders that might make cannabis administration hazardous are exclusionary.