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Autoimmune Protocol Diet Intervention on Proteinuria in IgA Nephropathy Patients

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Brief Summary

This study at UCLA Center for Health Sciences is testing whether the Autoimmune Protocol (AIP) diet can lower protein levels in the urine of people with IgA Nephropathy (IgAN), a common kidney disease that can lead to kidney failure. The AIP diet avoids foods that may cause inflammation (like dairy, grains, and sugar) for 8 weeks, then gradually reintroduces them over 4 months. We're enrolling 30 adults aged 18-65 with IgAN and protein in their urine to try this diet for 6 months. Participants will track their urine protein daily at home, keep a food log, and have monthly lab checkups, with support from a diet expert. The main goal is to see if the diet reduces urine protein by 20% or more, which could slow disease progression and reduce the need for treatments like dialysis. This exploratory study aims to find out if diet changes can help manage IgAN.

Primary Purpose
Treatment
Study Type
Interventional
Phase
N/A

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
18 Years
Maximum Age
65 Years

Inclusion Criteria:

  • Age 18-65
  • Diagnosed with IgA Nephropathy (IgAN)
  • Active disease with urine protein/creatinine ratio ≥ 1
  • Stable ARB or ACE inhibitor for at least 1 month prior
  • GFR > 30
  • Not on Budesonide 1 month prior or during study

Exclusion Criteria:

  • Inability to comply with dietary or follow-up requirements
  • Participation in other interventional studies
  • Significant comorbidities interfering with study participation -
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Study Stats
Protocol No.
25-0145
Category
Genitourinary Disorders
Principal Investigator
Thuy Tran
Contact
Thuy Tran
Location
  • UCLA Manhattan Beach
For Providers
NCT No.
NCT07022574
For detailed technical eligibility, visit ClinicalTrials.gov.