First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)
This study is one single group of participants with non-small cell lung cancer (NSCLC) who have not been cured by other treatments. It is the first time the drug has been used in humans, and will be in two parts.The primary purpose of the parts are: - Dose Escalation: To investigate the safety and tolerability and to determine the maximum tolerated dose (MTD) and the recommended dose for expansion (RDE) of DS-1062a - Dose Expansion: To investigate the safety and tolerability of DS-1062a in additional solid tumors This study is expected to last approximately 6 years from the time the first participant is enrolled to the time the last subject is off the study. Study sites are located in both the United States and Japan. The number of treatment cycles is not fixed in this study. Participants who continue to benefit from the study treatment may continue, unless: - they withdraw - their disease gets worse - they experience unacceptable side effects.
- Has relapsed or progressed following local standard treatments or for which no standard treatment is available.
- Consents to provide mandatory pre-treatment tumor tissue samples for the measurement of TROP2 and other biomarkers. There is no minimum TROP2 expression level required for inclusion.
- Consents to undergo mandatory on-treatment biopsy if clinically feasible and not contraindicated at the time of on-treatment biopsy, and consents to provide the tumor tissue samples from on-treatment biopsy for the measurement of TROP2 level and other biomarkers.
- Is aged ≥20 years old in Japan or ≥18 years old in other countries.
- Has an Eastern Cooperative Oncology Group performance status 0-1.
- Has a left ventricular ejection fraction (LVEF) ≥50% by either an ECHO or MUGA within 28 days before enrollment.
- Has measurable disease based on RECIST version1.1.
- Has adequate bone marrow reserve and organ function within 7 days before Cycle 1, Day 1.
- Has an adequate treatment washout period prior to Cycle 1, Day 1.
- If of reproductive/childbearing potential, agrees to use a highly effective from of contraception or avoid intercourse during and upon completion of the study and for at least 7 months for females and 4 months for males after the last dose of study drug, and agrees not to retrieve, freeze or donate sperm or ova starting at Screening and throughout the study period, and at least 7 months for males and 4 months for males after the final study drug administration.
- After being fully informed about their illness and the investigative nature of the protocol (including foreseeable risks and possible toxicities), is willing and able comply with the protocol and to provide written, ethics committee-approved informed consent form before performance of any study-specific procedures or examinations.
- Has a life expectancy of ≥3 months.
- Has no prior treatment with antibody drug conjugate with deruxtecan (including trastuzumab deruxtecan [T-DXd; DS-8201a] and patritumab deruxtecan [HER3-DXd; U31402]).
- Has no prior treatment with trophoblast cell surface antigen 2 (TROP2)-targeted therapy.
Additional Inclusion Criteria for NSCLC participants:
- Has a pathologically documented unresectable advanced NSCLC disease not amenable to curative therapy.
Additional Inclusion Criteria for TNBC participants:
- Has a pathologically documented advanced/unresectable or metastatic breast cancer with HR- (estrogen and progesterone receptor) negative disease and HER2 negative expression according to the American Society of Clinical Oncology - College of American Pathologists guidelines (ASCO-CAP).
Additional Inclusion Criteria for HR positive, HER2-negative participants:
- Pathologically documented unresectable or metastatic breast cancer that is:
- Positive for estrogen receptor and/or progesterone receptor
- Is documented refractory or resistant to endocrine therapy
- Was previously treated with a minimum of 1 and a maximum of 3 prior lines of chemotherapy in the advanced/metastatic setting
Additional Inclusion Criteria for Small-cell lung cancer (SCLC) participants:
- Pathologically documented unresectable or metastatic, and/or extensive-stage SCLC that was previously treated with 1 to 2 prior lines of therapy including platinum-based chemotherapy and immune checkpoint inhibitor.
- No prior exposure to topotecan.
Additional Inclusion Criteria for Endometrial cancer participants:
- Pathologically documented recurrent or persistent endometrial cancer that relapsed or progressed after any established and/or curative therapies, including at least 1 systemic therapy.
Additional Inclusion Criteria for Pancreatic adenocarcinoma participants:
- Pathologically documented unresectable or metastatic pancreatic cancer that was previously treated with at least 1 prior line of systemic therapy in neoadjuvant, adjuvant, locally advanced or metastatic setting.
Additional Inclusion Criteria for HER2-negative gastroesophageal cancer participants:
- Pathologically documented unresectable or metastatic adenocarcinoma of the stomach or esophagus, including the gastroesophagel junction (GEJ) that was previously treated with at least 1 prior line of systemic therapy.
- No known history of HER2-positivity (defined as Immunohistochemistry IHC 3+ or IHC 2+ and in situ hybridization ISH+) as classified by ASCO-CAP at any time.
Additional Inclusion Criteria for Esophageal cancer participants:
- Pathologically documented unresectable or metastatic squamous cell carcinoma of the esophagus that was previously treated with at least 1 prior line of therapy including platinum-based chemotherapy.
Additional Inclusion Criteria for Head and neck squamous cell carcinoma (HNSCC)
- Pathologically documented unresectable or metastatic HNSCC that was previously treated with 1-3 prior lines of therapy including platinum and ICI (in combination or sequential), in the advanced or metastatic setting.
Additional Inclusion Criteria for participants with advanced-stage urothelial cancer:
- Pathologically documented unresectable, locally advanced or metastatic, urothelial carcinoma (transitional cell and mixed transitional/non-transitional cell histologies) of the urothelium (including renal pelvis, ureters, urinary bladder, and urethra) that was previously treated with at least 1 prior line of therapy including platinum-based chemotherapy and immune checkpoint inhibitor (in combination or sequential).
Additional Inclusion Criteria for Colorectal cancer (CRC) participants:
- Pathologically documented unresectable or metastatic CRC that was previously treated with, or were not considered candidates for, available therapies including fluoropyrimidine-based chemotherapy, an anti-vascular. endothelial growth factor therapy, and an anti-epidermal growth factor (EGFR) therapy.
- Has not progressed or relapsed within 6 months of therapy with irinotecan.
Additional Inclusion Criteria for Platinum-resistant ovarian cancer participants:
- Pathologically documented unresectable or metastatic ovarian cancer that:
- Is epithelial ovarian (including less-common histologies per National Comprehensive Cancer Network (NCCN).
- Has relapsed or progressed within 6 months of platinum-based chemotherapy.
Additional Inclusion Criteria for Platinum-sensitive ovarian cancer participants:
- Pathologically documented unresectable or metastatic ovarian cancer that:
- Is epithelial ovarian (including less-common histologies per NCCN guidelines), fallopian tube, or primary peritoneal presentation.
- Has relapsed or progressed at least 6 months after the most recent platinum-based chemotherapy.
Additional Inclusion Criteria for Cervical cancer participants:
- Pathologically documented unresectable or metastatic cervical cancer that relapsed or progressed after at least 1 prior line of systemic therapy.
Additional Inclusion Criteria for Castration-resistant prostate cancer participants:
- Pathologically documented unresectable or metastatic CRPC that:
- Is adenocarcinoma of the prostate without neuroendocrine differentiation or small cell histology.
- Is surgically or medically castrated, with testosterone levels of less than 50 nanograms per deciliter.
- Objective progression as determined by radiographic progression for participants with measurable disease after androgen deprivation.
- Has relapsed or progressed after at least 1 of the following: abiraterone or enzalutamide.
- Has relapsed or progressed after at least 1, but not more than 2, cytotoxic chemotherapy regimens for metastatic castration resistant prostate cancer (mCRPC). At least 1 regimen must have contained a taxane. If a specific taxane was used more than once, the regimens containing the same taxane would be considered as 1 regimen in total.
Additional Inclusion Criteria for Participants with Bacillus Calmette-Guerin
(BCG)-unresponsive (BCGu) High-Risk Non-Muscle Invasive Bladder Cancer (NMIBC)
- Histologically confirmed diagnosis of high-risk non-muscle-invasive transitional cell carcinoma of the bladder. Participants with tumors of mixed transitional/non-transitional cell histology are allowed, but transitional cell carcinoma must be the predominant histology. Participants with predominant or exclusively non-transitional cell histology are not allowed.
- Participants who have papillary tumors (Ta and T1), a complete TURBT must have been performed.
- Prior treatment with adequate BCG therapy and development of high-risk NMIBC that is unresponsive to BCG therapy.
- Has elected not to undergo, or is considered ineligible for radical cystectomy, as determined by the treating surgeon.
- Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0, 1, or 2 for BCGu-NMIBC.
- Receipt of one prior course of checkpoint inhibitor therapy (eg, anti-PD-1 or anti-PD-L1 monoclonal antibody) administered for BCGu-NMIBC is permitted; such participants must have either persistence or recurrence of NMIBC following such therapy.
- Has a history of malignancy, other than a tumor type specified in the Inclusion Criteria, except (a) adequately resected non-melanoma skin cancer, (b) curatively treated in situ disease, or (c) other solid tumors curatively treated, with no evidence of disease for ≥3 years.
- Uncontrolled or significant cardiac disease including myocardial infarction or uncontrolled/unstable angina within 6 months prior to Cycle 1 Day 1.
- History of congestive heart failure (New York Heart Association classes II-IV) or uncontrolled or significant cardiac arrhythmia, uncontrolled hypertension(resting systolic blood pressure >180 mm Hg or diastolic blood pressure >110 mm Hg).
- Has a mean corrected QT interval (QTcF) prolongation to >470 ms based on of the screening triplicate 12-lead ECGs.
- Has a history of non-infectious interstitial lung disease (ILD)/pneumonitis that required steroids, has current ILD/pneumonitis, or where suspected ILD/pneumonitis cannot be ruled out by imaging at screening.
- Has clinically significant corneal disease.
- Has an uncontrolled infection requiring IV antibiotics, antivirals, or antifungals.
- Has active human immunodeficiency virus (HIV) infection that is uncontrolled (increasing plasma HIV RNA viral load) with medication, or has an active or uncontrolled hepatitis B and/or hepatitis C infection, is positive for hepatitis B or C virus based on the evaluation of results of tests for hepatitis B (hepatitis B surface antigen [HBsAg], anti-hepatitis B surface antibody [anti-HBs], anti-hepatitis B core antibody [anti-HBc], or hepatitis B virus [HBV] DNA) and/or hepatitis C infection (as per HCV RNA) within 28 days of Cycle 1 Day 1.
- Has spinal cord compression or clinically active brain metastases, defined as untreated and symptomatic, or requiring therapy with steroids or anticonvulsants to control associated symptoms. Participants with clinically inactive brain metastases may be included in the study. A minimum of 2 weeks must have elapsed between the end of whole brain radiotherapy and study enrollment. Participants with treated brain metastases that are no longer symptomatic and who require no treatment with steroids may be included in the study if they have recovered from the acute toxic effect of radiotherapy.
- Is lactating or pregnant as confirmed by pregnancy tests performed within 7 days before enrollment.
- Has unresolved toxicities from previous anticancer therapy.
- Has a concomitant medical condition that would increase the risk of toxicity, in the opinion of the Investigator.
- Has a history of severe hypersensitivity reactions to either the drug substances or inactive ingredients of DS-1062a. Has a history of severe hypersensitivity reaction to other monoclonal antibodies.
- Has any other medical conditions, including cardiac disease or psychological disorders, and/or substance abuse that would increase the safety risk to the participant or interfere with participation of the participant or evaluation of the clinical study in the opinion of the Investigator.
- Clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses including, but not limited to, any underlying pulmonary disorder, or any autoimmune, connective tissue or inflammatory disorders with pulmonary involvement, or prior pneumonectomy.
- Has leptomeningeal carcinomatosis.
- Has substance abuse or any other medical conditions such as clinically significant cardiac or psychological conditions, that may, in the opinion of the investigator, interfere with the participant's participation in the clinical study or evaluation of the clinical study results.
- Psychological, social, familial, or geographical factors that would prevent regular follow-up. Adults under guardianship, curatorship, safeguard of justice, or family empowerment measure are not eligible.
- Otherwise considered inappropriate for the study by the investigator.
Additional Exclusion Criteria for Participants with BCGu NMIBC
- Has muscle invasive (ie, T2, T3, T4) locally advanced non-resectable or metastatic urothelial carcinoma.
- Has concurrent extra-vesical (ie, urethra, ureter or renal pelvis) non-muscle invasive transitional cell carcinoma of the urothelium.
- Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment.
- Has undergone any intervening intravesical chemotherapy or immunotherapy from the time of most recent cystoscopy/transurethral resection of bladder tumor (TURBT) to starting trial treatment.