High Potency Cannabis: Acute and Protracted Effects

About

Brief Summary

The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.

Primary Purpose

Basic science

Study Type

Interventional

Phase

Phase 1

Eligibility

Gender

All

Healthy Volunteers

Yes

Minimum Age

21 Years

Maximum Age

55 Years

Inclusion Criteria:

- Male or non-pregnant and non-lactating females aged 21-55 years
- Report cannabis smoking near daily
- Not currently seeking treatment for their cannabis use
- Have a Body Mass Index from 18.5 - 34kg/m2.
- Able to perform all study procedures
- Must be using a contraceptive (hormonal or barrier methods)

Exclusion Criteria:

Meeting DSM-V criteria for any substance use disorder other than cannabis, nicotine, caffeine
Do not have positive urine toxicology for cannabis use during screening
Evidence of severe psychiatric illness (e.g. mood or anxiety disorder with functional impairment or suicide risk, schizophrenia) judged by the study physician (and PI) to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
Report using other illicit drugs in the prior 4 weeks
Current predominant licit use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
Current pain
Pregnancy
Currently enrolled in another research protocol
Not using a contraceptive method (hormonal or barrier methods)
Insensitivity to the cold water stimulus of the Cold Pressor Test
Any disorders that might make cannabis administration hazardous as determined by evaluation physician after review of all medical assessments along with medical history.
Not able to speak and read English