Open Actively Recruiting

Key Dimensions of PTSD and ED


Brief Summary

This study will test whether endothelial dysfunction could be the early subclinical mechanism by which posttraumatic stress disorder (PTSD) increases cardiovascular disease (CVD) risk, and whether posttraumatic fear-a key component of PTSD-or another PTSD dimension could be the target to offset that risk. The results of this study may help trauma-exposed individuals who are at risk of having CVD events.

Study Type


Healthy Volunteers
Minimum Age
18 Years
Maximum Age

Inclusion Criteria:

  • Aged 18+ years
  • History of exposure to a psychological trauma (e.g., natural disaster, physical assault)
  • Fluent in English
  • Willing to and capable of providing informed consent

Additional Inclusion Criteria for the PTSD Group

  • Diagnosed with current PTSD (duration of at least 1 month) using the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual 5th Edition (DSM-5) (CAPS-5) at the diagnostic interview assessment

Exclusion Criteria:

  • History of CVD (i.e., diagnosis of myocardial infarction, unstable angina, heart failure, peripheral artery disease, or stroke)
  • Deemed unable to comply with the protocol (either self-selected or by indicating during screening that could not complete all requested tasks)
  • Current bipolar disorder or psychotic disorder
  • Mild or more severe cognitive impairment [Mini-Mental State Exam (MMSE)3 score ≤18]
  • Current moderate or severe substance use disorder
  • Acute, unstable, or severe medical disorder or pregnancy
  • Deemed to need immediate psychiatric intervention (e.g., active suicidality)
  • Use of antipsychotic, mood stabilizer, antidepressant, or stimulant medication in the past 4 weeks
  • Daily benzodiazepine use in the past 2 weeks

Additional Exclusion Criteria for the Trauma-Exposed Matched Control Group

  • Current or past diagnosis of any DSM-5 psychiatric disorder
  • CAPS-5 total score ≥25

Join this Trial

Contact our clinical trial navigators for opportunities that may be suitable for you
Study Stats
Protocol No.
Mental Health
Principal Investigator
Jennifer Sumner
Tiffany Chen
  • UCLA Westwood
For Providers
For detailed technical eligibility, visit