Open Actively Recruiting

Luteolin for the Treatment of People With Schizophrenia


Brief Summary

Luteolin is a natural product found in foods such as celery, green pepper, parsley, and chamomile tea. It has been found to have anti-cancer, anti-oxidant, and anti-inflammatory properties. The purpose of this study is to determine if luteolin helps improve symptoms of schizophrenia.

Primary Purpose
Study Type
Phase 4


Healthy Volunteers
Minimum Age
18 Years
Maximum Age
60 Years

Inclusion Criteria:

  • Either male or female of any race
  • Age is 18-60 years old
  • Meets DSM-5 criteria for schizophrenia or schizoaffective disorder
  • Positive and Negative Syndrome Scale (PANSS) total score of 75 or more OR a Clinical Global Impression severity of illness item score of 4 or more
  • Clinically stable
  • Treated with the same antipsychotic for at least 60 days and have received a constant therapeutic dose for at least 30 days prior to study entry
  • Able to participate in the informed consent process and provide voluntary informed consent

Exclusion Criteria:

  • Meets DSM-5 criteria for alcohol or substance misuse (except caffeine and nicotine) within the last 6 months; or a positive baseline urine drug screen. Participants who meet DSM-5 criteria for marijuana misuse - mild will be included in the study
  • A current infection, including HIV and Hepatitis C; or an organic brain disorder or medical condition, whose pathology or treatment could alter the presentation or treatment of schizophrenia or significantly increase the risk associated with the proposed treatment protocol
  • Currently taking immunosuppressive medications (e.g. oral scheduled corticosteroids, chemotherapy or transplantation or HIV/AIDs associated drugs); or anti-inflammatory medications, including NSAIDs (e.g. ibuprofen, celecoxib, or naproxen) or aspirin > 81 mg on a daily basis. The use of PRN anti-inflammatory agents will be allowed.
  • Female participants who are pregnant or nursing

Join this Trial

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Study Stats
Protocol No.
Mental Health
Principal Investigator
Gerard De Vera
  • UCLA Westwood
For Providers
For detailed technical eligibility, visit