Open Actively Recruiting

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)


Brief Summary

The purpose of this study is to compare the effects of three on-line wellness interventions for improving physical and cognitive function and brain connectivity in adults who are at least 55 years old and are experiencing symptoms of memory and/or cognitive difficulties.

Primary Purpose
Study Type


Healthy Volunteers
Minimum Age
55 Years
Maximum Age

Inclusion Criteria:

  • age ≥ 55 years
  • subjective cognitive complaints, defined as self-experienced persistent decline in cognitive capacity in comparison with a previously normal status and unrelated to an acute event
  • Montreal Cognitive Assessment (MoCA) score suggestive of Mild Cognitive Impairment (MCI) status (i.e., < 26)
  • English language fluency
  • Wireless internet connection at home
  • Willingness to travel to the San Francisco VA in northern California or UCLA in southern California for in-person assessments at baseline, after the 12-week interventions, and at the 36-week follow-up
  • Capacity to provide informed consent or legally authorized representative consent and participant assent.

Exclusion Criteria:

  • current or past Axis I psychiatric disorders, or recent unstable medical or neurological disorders
  • disabilities that prevent participation in on-line movement classes (e.g., primarily use wheel-chair, severe visual impairment that would limit ability to observe instructor's movement on screen or severe hearing impairment that would limit ability to hear instructor's directions)
  • insufficient English proficiency
  • limited life expectancy (i.e., enrolled in hospice, metastatic cancer)
  • plan to travel for > 1 week during 12-week intervention period
  • diagnosis of dementia per the DSM-5
  • MoCA score suggestive of dementia (i.e., <17)
  • started dementia medication (cholinesterase inhibitor or memantine) in past 3 months or plans to start dementia medication during study period
  • planning to start/change any psychoactive medication during study period
  • current participation in another research study
  • contraindications to magnetic resonance imaging (MRI), including claustrophobia severe enough to prevent MRI examination, presence of ferrometallic objects in the body that would interfere with MRI examination and/or cause a safety risk (e.g., pacemakers, implanted stimulators, pumps)
  • prior or current training in with Tai Chi, PLIE, or other mind-body practices

Join this Trial

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Study Stats
Protocol No.
Mental Health
Courtney Sheen
For Providers
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