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Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease

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Brief Summary

Several strategies or contexts help patients with Parkinson's disease to move more quickly or normally, however the brain mechanisms underlying these phenomena are poorly understood. The proposed studies use complimentary brain mapping techniques to understand the brain mechanisms supporting improved movements elicited by external cues. The central hypothesis is that distinct networks are involved in movement improvement depending on characteristics of the facilitating stimulus. Participants will perform movement tasks during recording of brain activity with EEG and MRI. The identified biomarkers may provide targets for future neuromodulation therapies to improve symptoms that are refractory to current treatments, such as freezing of gait.

Primary Purpose
Basic Science
Study Type
Interventional
Phase
N/A

Eligibility

Gender
All
Healthy Volunteers
Yes
Minimum Age
18 Years
Maximum Age
N/A

Inclusion Criteria:

  • Diagnosis of Parkinson's disease based on presence of at least 2 cardinal features (tremor, rigidity or bradykinesia) OR healthy adult with no neurologic disease
  • Age > 18 years old

Exclusion Criteria:

  • Dementia as indicated by score on Montreal Cognitive Assessment < 19
  • Active hallucinations or psychosis
  • Contraindications to MRI (metal implant, claustrophobia)

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Study Stats
Protocol No.
19-002135
Category
Brain/Neurological Diseases
Contact
Mai Miura
For Providers
NCT No.
NCT05179187
For detailed technical eligibility, visit ClinicalTrials.gov.