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Postoperative Neurocognitive Disorders

About

Brief Summary

The purpose of this study is to examine the mechanisms of brain injury contributing to postoperative neurocognitive disorders (PNCD) in an at-risk population (obstructive sleep apnea (OSA)) undergoing surgery. The investigators will enroll 50 OSA patients scheduled for surgery. All patients will have a brain scan (fMRI) within five days before surgery and two days and six months after surgery. During this visit cognitive function will be assessed using the Wide Range Assessment of Memory and Learning (WRAML2) and Montreal Cognitive Assessment (MoCA) tests. Patients will also be asked to participate in a blood draw during the first 2 visits for fMRI (within five days of surgery and two days after surgery). The Confusion Assessment Method (CAM-S) test, will be used to examine postoperative delirium.

Study Type
Observational

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
40 Years
Maximum Age
75 Years

Inclusion Criteria:

Subjects with a diagnosis of moderate-to-severe OSA (apnea hypopnea index [AHI]>15 events/hour confirmed by overnight polysomnography), scheduled for open or robotic surgery (abdominal, gynecologic, or urologic), and upper or lower extremity orthopedic procedures

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Study Stats
Protocol No.
19-001597
Category
Anesthesiology & Perioperative Medicine
Contact
CLAUDIA BUENO
Location
  • UCLA Westwood
For Providers
NCT No.
NCT04244162
For detailed technical eligibility, visit ClinicalTrials.gov.