A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

About

Brief Summary

The purpose of the study is to explore the safety and effects of the study drug (PF-08046876) in people diagnosed with advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas. PF-08046876 is an investigational anticancer therapy called an 'antibody drug conjugate' or 'ADC'. ADCs are anticancer drugs designed to stick to cancer cells and kill them.

The study drug will be given to participants through a needle in a vein (intravenous infusion). This study includes multiple parts. In the first part of the study, there will be different groups of people receiving different doses of the study drug. The study may also test different schedules.

Primary Purpose

Treatment

Study Type

Interventional

Phase

Phase 1

Eligibility

Gender

All

Healthy Volunteers

No

Minimum Age

18 Years

Maximum Age

N/A

Inclusion Criteria:

18 years of age or older
Advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas
Measurable disease
ECOG Performance status 0-1
Part 1: progression or relapse following standard treatments
Part 2: maximum of 2 prior lines of systemic therapy in the advanced setting
Resolution of acute effects of prior anticancer therapy to baseline or Grade 1
Consent to submit required pre-treatment tumor tissue as medically feasible

Exclusion criteria:

Received prior treatment with an antibody drug conjugate with a camptothecin-class payload (e.g. sacituzumab govitecan, trastuzumab deruxtecan )
Active anorexia, nausea or vomiting, and/or signs of intestinal obstruction meeting protocol exclusion
Pulmonary disease meeting protocol exclusion
Other unacceptable abnormalities as defined by protocol

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