Open
Actively Recruiting
UR+AIMS Gout Wearable Skin Uric Acid Monitor Study
About
Brief Summary
15 patients with gout [10 patients no recent urate-lowering therapy (ULT) and 5 patients on stable urate-lowering therapy (ULT)] will be invited to participate in a standardized meal at the UCLA Human Nutrition Center and a 7-day community follow-up for the measurement of uric acid (and other metabolites) using our Uric Acid and Metabolite Monitor System (UR+AIMS) skin patch.
Primary Purpose
Study Type
Phase
Eligibility
Gender
Healthy Volunteers
Minimum Age
Maximum Age
Inclusion Criteria:
- Age > 18 with diagnosis of gout (screening positive ACR/EULAR Gout Classification Criteria - see screening survey) and eGFR > 60 (within the last 12-months).
- For the 10 patients with gout off urate-lowering therapy (ULT) [no Allopurinol, febuxostat, or probenecid prescription within the last 6-months] and serum urate (SU) > 7 mg/dL (within the last 12-months).
- For the 5 patients with gout on urate-lowering therapy (ULT) [no dose change within the last 30 days].
Exclusion Criteria:
- Contraindications to miosis, which include acute iritis, narrow-angle glaucoma
- Known Hypersensitivity to pilocarpine hydrochloride
- Pupillary block glaucoma (ophthalmic solution)
- Subjects reporting any allergy to glue or latex or any allergy to food that will be provided in the study (sardines in extra virgin olive oil and Sprite).
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Study Stats
Protocol No.
22-001566
Category
Musculoskeletal Disorders
Principal Investigator
Contact
Location
- UCLA Westwood