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UR+AIMS Gout Wearable Skin Uric Acid Monitor Study

About

Brief Summary

15 patients with gout [10 patients no recent urate-lowering therapy (ULT) and 5 patients on stable urate-lowering therapy (ULT)] will be invited to participate in a standardized meal at the UCLA Human Nutrition Center and a 7-day community follow-up for the measurement of uric acid (and other metabolites) using our Uric Acid and Metabolite Monitor System (UR+AIMS) skin patch.

Primary Purpose
Diagnostic
Study Type
Interventional
Phase
Phase I/II

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
18 Years
Maximum Age
N/A

Inclusion Criteria:

  • Age > 18 with diagnosis of gout (screening positive ACR/EULAR Gout Classification Criteria - see screening survey) and eGFR > 60 (within the last 12-months).
  • For the 10 patients with gout off urate-lowering therapy (ULT) [no Allopurinol, febuxostat, or probenecid prescription within the last 6-months] and serum urate (SU)

    7 mg/dL (within the last 12-months).

  • For the 5 patients with gout on urate-lowering therapy (ULT) [no dose change within the last 30 days].

Exclusion Criteria:

  • Contraindications to miosis, which include acute iritis, narrow-angle glaucoma
  • Known Hypersensitivity to pilocarpine hydrochloride
  • Pupillary block glaucoma (ophthalmic solution)
  • Subjects reporting any allergy to glue or latex or any allergy to food that will be provided in the study (sardines in extra virgin olive oil and Sprite).

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Study Stats
Protocol No.
22-001566
Category
Musculoskeletal Disorders
Contact
Gail Thames
Location
  • UCLA Westwood
For Providers
NCT No.
NCT06187519
For detailed technical eligibility, visit ClinicalTrials.gov.