Ablative
Device name: Peregrine System Infusion Catheter
- Phase 2, blinded, sham procedure
Mechanism: renal denervation using alcoholas a neurolytic agent
- Evaluate safety of Peregrine catheter to deliver 0.6mL alcohol to perivascular area of reneal arteries
Key inclusion criteria:
- Age: 18-80 (inclusive)
- On 2-5 antihypertensive medications, willing to adhere to regimen and a diuretic
- 3 in office BP measurements; average SBP ≥ 150 and ≤ 180, DPB ≥ 90
Exclusion:
- Sleep apnea, thyroid/parathyroidabnormalities, heart failure, chronic NSAID use, immunosuppresive medications
- Renal artery abnormalities that may impact renal denervation procedure