Pfizer - FSGS

Drug name: PF-06730512

  • Phase 2a, open-label
  • Mechanism: acts as a SLIT neutralizing ligand trap to inhibit nephrin-induced actin polymerization

Key inclusion criteria:

  • Age > 18 years
  • eGFR > 45
  • UPCR > 1.5 g/g

Exclusion:

  • any immunosuppressant medications within 28 days prior to Lead-In period (besides corticosteroids, MMF, or CNIs)