Andrew D. Watson, MD, PhD

The role of oxidized phospholipid in atherosclerosis and inflammation.

1. Gugiu, B. G., Mouillesseaux, Duong, V., Herzog, T., Hekimian, A., Koroniak, L., Vondriska, T. M., Watson, A. D., Protein targets of oxidized phospholipids in endothelial cells, J. Lipid Res., 49:510-520, 2008.
2. Cruz, D., Watson, A. D., Miller C. S., Montoya, D., Ochoa, M. T., Sieling, P. A., Gutierrrez, M. A., Navab, M., Reddy, S. T., Witztum, J. L., Fogelman, A. M., Rea, T. H., Eisenberg, D., Berliner, J. A., and Modlin, R. L., Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy, J. Clin. Invest., 118:2917-2928, 2008.
3. Watson, K. E., Ansel, B. J., Watson, A. D., and Fonarow, G. C., HDL function as a target of lipid-modifying therapy, Rev. Cardiovasc. Med., 8:1-8, 2007.
4. Watson, A. D., Thematic review series:  systems biology approaches to metabolic and cardiovascular disorders.  Lipidomics:  a global approach to lipid analysis in biological systems, J. Lipid Res., 47:2101-2011, 2006
5. Berliner, J. A. and Watson, A. D., A role for oxidized phospholipids in atherosclerosis, N. Engl. J. Med., 353:9-11, 2005.
6. Watson, A. D., Subbanagounder, G., Welsbie, D. S., Faull, K. F., Navab, M., Jung, M. E., Fogelman, A. M., and Berliner, J. A., Structural identification of a novel pro-inflammatory expoxyisoprostane phospholipid in mildly oxidized low density lipoprotein, J. Biol. Chem., 274(35):24787-24798, 1999.
7. Watson, A. D., Leitinger, N., Navab, M., Faull, K. F., Horkko, S., Witztum, J. L., Palinski, W., Schwenke, D., Solomon, R. G., Wha, W., Subbanagounder, G., Fogelman, A. M., and Berliner, J. A., Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo, J. Biol. Chem., 272:13597-13607, 1997.
8. Berliner, J. A. and Watson, A. D., the role of oxidized lipids in cardiovascular disease, in Active Oxygen:  Reactive Oxygen Species in Biochemistry, (Valentin, J. S., Foote, C. S., Greenberg, A., and Leibman, J. F. eds) Chapman Hall, 1995.
9. Watson, A. D., Berliner, J. A., Hama, S. Y., La Du, B. N., Faull, K. F., Fogelman, A. M., and Navab, M., Protective effect of high density lipoprotein associated paraoxonase.  Inhibition of the biologically activity of minimally oxidized lipoprotein, J. Clin. Invest., 96:2882-2891, 1995.
10. Watson, A. D., Navab, M., Hama, S. Y., Sevanian, A., Prescott, S. M., Stafforini, D. M., McIntyre, T. M., La Du, B. N., Fogelman, A. M., and Berliner, J. A., Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein, J. Clin Invest., 95:774-782, 1995.

• UCLA Cardiology Fellowship Teaching Award, 2005
• Edith and Carl Lasky Memorial Award for Distinguished Research Achievement as a Medical Student, 2000
• 1st Annual George J. Popjak Scholar, 1999
• American Heart Association Greater Los Angeles Affiliate Laverna Titus Young Investigator's Forum, Grand Prize: Best Overall Presentation in Clinical and Basic Research, 1995
• UCLA Alumni Graduate Distinguished Scholar, 1993

• uclahealth.org/heart