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Nelson B. Freimer, MD

Psychiatry

About

Dr. Nelson Freimer is Director of the Center for Neurobehavioral Genetics and Professor of Psychiatry at UCLA and Associate Director for Research Programs of the Semel Institute for Neuroscience and Human Behavior. He also directs UCLA core facilities in genomics and neuroscience (The Informatics Center for Neurogenetics and Neurogenomics, The UCLA Neuroscience Genomics Core, and The Biological Samples Processing Core). He is Director of the NINDS-funded Postdoctoral Training Program in Neurobehavioral Genetics, and Co-Director of UCLA Neuroscience. Dr. Freimer received an M.D. degree from the Ohio State University, and completed residency training in psychiatry (at UC San Francisco) and a postdoctoral fellowship in human genetics (at Columbia University). He joined the UCLA faculty in 2000 after 10 years on the faculty at UC San Francisco.

The research in Dr. Freimer's laboratory aims to use large scale genomics methods to identify the genetic basis of complex traits, particularly neurobehavioral disorders including bipolar disorder, schizophrenia, depression, and Tourette Syndrome. He has also conducted large-scale genomics studies of metabolic phenotypes and cardiovascular disorders. His research group has pioneered in whole genome sequencing studies of such disorders as well as the application of large-scale genomics to our understanding of non-human primates.

Languages

English

Education

Medical Board Certification

Psychiatry, American Board of Psychiatry and Neurology, 1989

Fellowship

New York State Psychiatric Institute, 1990

Residency

UCSF Department of Psychiatry, 1986

Internships

UCSF Department of Medicine & Med Specialties, 1984
Yale-New Haven Hospital, 1983

Degree

Ohio State University College of Medicine, MD, 1982

Hospital Affiliations

Ronald Reagan UCLA Medical Center

Research

Publications

  1. Nag Abhishek, Bochukova Elena G, Kremeyer Barbara, Campbell Desmond D, Muller Heike, Valencia-Duarte Ana V, Cardona Julio, Rivas Isabel C, Mesa Sandra C, Cuartas Mauricio, Garcia Jharley, Bedoya Gabriel, Cornejo William, Herrera Luis D, Romero Roxana, Fournier Eduardo, Reus Victor I, Lowe Thomas L, Farooqi I Sadaf, Farooqi I Sadaf, Mathews Carol A, McGrath Lauren M, Yu Dongmei, Cook Ed, Wang Kai, Scharf Jeremiah M, Pauls David L, Freimer Nelson B, Plagnol Vincent, Ruiz-Linares Andrãs CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1 PloS one, 2013; 8(3): e59061.
  2. Chen Kevin, Budman Cathy L, Diego Herrera Luis, Witkin Joanna E, Weiss Nicholas T, Lowe Thomas L, Freimer Nelson B, Reus Victor I, Mathews Carol A Prevalence and clinical correlates of explosive outbursts in Tourette syndrome Psychiatry research, 2013; 205(3): 269-75.
  3. Ma Dongzhu, Jasinska Anna, Kristoff Jan, Grobler J Paul, Turner Trudy, Jung Yoon, Schmitt Christopher, Raehtz Kevin, Feyertag Felix, Martinez Sosa Natalie, Wijewardana Viskam, Burke Donald S, Robertson David L, Tracy Russell, Pandrea Ivona, Freimer Nelson, Apetrei Cristian, Apetrei Cristian SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations PLoS pathogens, 2013; 9(1): e1003011.
  4. Cramer Jennifer Danzy, Gaetano Tegan, Gray Joseph P, Grobler Paul, Lorenz Joseph G, Freimer Nelson B, Schmitt Christopher A, Turner Trudy R Variation in Scrotal Color Among Widely Distributed Vervet Monkey Populations (Chlorocebus Aethiops Pygerythrus and Chlorocebus Aethiops Sabaeus) American journal of primatology, 2013.
  5. Jasinska Anna J, Lin Michelle K, Service Susan, Choi Oi-Wa, Deyoung Joseph, Grujic Olivera, Kong Sit-Yee, Jung Yoon, Jorgensen Mathew J, Fairbanks Lynn A, Turner Trudy, Cantor Rita M, Wasserscheid Jessica, Dewar Ken, Warren Wesley, Wilson Richard K, Weinstock George, Jentsch J David, Freimer Nelson B. A non-human primate system for large-scale genetic studies of complex traits Human molecular genetics, 2012; 15(6): .
  6. Congdon Eliza, Service Susan, Wessman Jaana, Seppãnen Jouni K, Schãnauer Stefan, Miettunen Jouko, Turunen Hannu, Koiranen Markku, Joukamaa Matti, Jãrvelin Marjo-Riitta, Peltonen Leena, Veijola Juha, Mannila Heikki, Paunio Tiina, Freimer Nelson B. Early environment and neurobehavioral development predict adult temperament clusters PloS one, 2012; 7(7): e38065.
  7. McQuillan Ruth, Eklund Niina, Pirastu Nicola, Kuningas Maris, McEvoy Brian P, Esko Tãnu, Corre Tanguy, Davies Gail, Kaakinen Marika, Lyytikãinen Leo-Pekka, Kristiansson Kati, Havulinna Aki S, Gãgele Martin, Vitart Veronique, Tenesa Albert, Aulchenko Yurii, Hayward Caroline, Johansson Asa, Boban Mladen, Ulivi Sheila, Robino Antonietta, Boraska Vesna, Igl Wilmar, Wild Sarah H, Zgaga Lina, Amin Najaf, Theodoratou Evropi, Polaek Ozren, Girotto Giorgia, Lopez Lorna M, Sala Cinzia, Lahti Jari, Laatikainen Tiina, Prokopenko Inga, Kals Mart, Viikari Jorma, Yang Jian, Pouta Anneli, Estrada Karol, Hofman Albert, Freimer Nelson, Martin Nicholas G, Kãhãnen Mika, Milani Lili, Heliãvaara Markku, Vartiainen Erkki, Rãikkãnen Katri, Masciullo Corrado, Starr John M, Hicks Andrew A, Esposito Laura, Koli Ivana, Farrington Susan M, Oostra Ben, Zemunik Tatijana, Campbell Harry, Kirin Mirna, Pehlic Marina, Faletra Flavio, Porteous David, Pistis Giorgio, Widãn Elisabeth, Salomaa Veikko, Koskinen Seppo, Fischer Krista, Lehtimãki Terho, Heath Andrew, McCarthy Mark I, Rivadeneira Fernando, Montgomery Grant W, Tiemeier Henning, Hartikainen Anna-Liisa, Madden Pamela A F, d'Adamo Pio, Hastie Nicholas D, Gyllensten Ulf, Wright Alan F, van Duijn Cornelia M, Dunlop Malcolm, Rudan Igor, Gasparini Paolo, Pramstaller Peter P, Deary Ian J, Toniolo Daniela, Eriksson Johan G, Jula Antti, Raitakari Olli T, Metspalu Andres, Perola Markus, Jãrvelin Marjo-Riitta, Uitterlinden Andrã, Visscher Peter M, Wilson James F, Wilson James F Evidence of inbreeding depression on human height PLoS genetics, 2012; 8(7): e1002655.
  8. Kettunen Johannes, Tukiainen Taru, Sarin Antti-Pekka, Ortega-Alonso Alfredo, Tikkanen Emmi, Lyytikãinen Leo-Pekka, Kangas Antti J, Soininen Pasi, Wãrtz Peter, Silander Kaisa, Dick Danielle M, Rose Richard J, Savolainen Markku J, Viikari Jorma, Kãhãnen Mika, Lehtimãki Terho, Pietilãinen Kirsi H, Inouye Michael, McCarthy Mark I, Jula Antti, Eriksson Johan, Raitakari Olli T, Salomaa Veikko, Kaprio Jaakko, Jãrvelin Marjo-Riitta, Peltonen Leena, Perola Markus, Freimer Nelson B, Ala-Korpela Mika, Palotie Aarno, Ripatti Samuli Genome-wide association study identifies multiple loci influencing human serum metabolite levels Nature genetics, 2012; 44(3): 269-76.
  9. Levine Andrew J, Service Susan, Miller Eric N, Reynolds Sandra M, Singer Elyse J, Shapshak Paul, Martin Eileen M, Sacktor Ned, Becker James T, Jacobson Lisa P, Thompson Paul, Freimer Nelson. Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012; 15(6): .
  10. Miettunen Jouko, Isohanni Matti, Paunio Tiina, Freimer Nelson, Taanila Anja, Ekelund Jesper, Jãrvelin Marjo-Riitta, Joukamaa Matti, Lichtermann Dirk, Koivumaa-Honkanen Heli, Veijola Juha Predicting depression with psychopathology and temperament traits: the northern Finland 1966 birth cohort Depression research and treatment, 2012; 2012(7411): 160905.