Patrick A. Kupelian, MD

Patrick A. Kupelian, MD

Radiation Oncology
Accepting new patients


Dr. Kupelian is a Professor of Radiation Oncology at UCLA. He completed his residency training in radiation oncology at the University of Texas M.D. Anderson Cancer Center in Houston, and completed a fellowship at the Cleveland Clinic Foundation. Following his fellowship, he was the section head of genitourinary malignancies in the Department of Radiation Oncology at the Cleveland Clinic for 8 years. He also served as the Clinical Research Director of the Department of Radiation Oncology at the Cleveland Clinic Foundation. Dr. Kupelian comes to UCLA from M.D. Anderson Cancer Center in Orlando, FL, where he was the Chairman and Scientific Director of Research for Radiation Oncology, and a Professor at the University of Central Florida.

Although he specializes in genitourinary malignancies, he an internationally known expert in the development and evaluation of cutting edge technologies in Radiation Oncology for a variety of anatomic sites. He has pionneered high-dose hypofractionated radiation therapy for prostate cancers. He has also played a significant role in the introduction and implementation of multiple image guidance techniques in radiotherapy. He has authored more than 200 research papers, multiple review papers and book chapters.

He is board certified in Radiation Oncology. He is a member of the American Society of Therapeutic Radiation and Oncology (ASTRO), the European Society of Therapeutic Radiology and Oncology, American Society of Clinical Oncology, the American Urological Association and the American Brachytherapy society. He has served on many committees within ASTRO. He is a reviewer for several medical journals including International Journal of Radiation Oncology Biology Physics, the Journal of Urology, Radiotherapy and Oncology, Cancer, the Journal of Clinical Oncology, the British Journal of Urology, and Physics in Medicine and Biology. He is active in national and international lecture series. He has conducted multiple educational courses at ASTRO and RSNA among others. He also serves as an examiner at the American Board of Radiology.


French, Armenian, Arabic, English


Medical Board Certification

Radiation Oncology, American Board of Radiology, 1995


Cleveland Clinic Foundation, 1996


University of Texas - M.D. Anderson Cancer Center, 1994


American University of Beirut Medical School, 1990


American University of Beirut Medical School, MD, 1989

Hospital Affiliations

Ronald Reagan UCLA Medical Center

UCLA Santa Monica Medical Center



Review Articles

  1. Ruan D, Kupelian PA, Low D: Image-guided positioning and tracking. Cancer J. 17(3):155-8, 2011
  2. Kupelian PA, Langen K: Helical tomotherapy: image-guided and adaptive radiotherapy. Front RadiatTherOncol: 43:165-80, 2011
  3. Kupelian PA, Meyer J: Image-guided, adaptive radiotherapy of prostate cancer: toward new standards of radiotherapy practice. Front RadiatTherOncol: 43:344-68, 2011
  4. Kupelian PA, Sonke JJ. Magnetic Resonance-Guided Adaptive Radiotherapy: A Solution to the Future. SeminRadiatOncol. 24(3):227-232. 2014

Peer Reviewed

  1. Zeidan O, Huddleston A, Lee C, Langen K, Kupelian PA, Meeks S, Manon R: A Comparison of Soft-Tissue Implanted Markers and Bony Anatomy Alignments for Image-Guided Treatments of Head-and-Neck Cancers. Int J RadiatOncolBiol Phys. 76(3):767-774, 2010
  2. Potters L, Gaspar L, Kavanagh B, Galvin J, Hartford A, Hevezi J, Kupelian PA, Mohiden N, Samuels M, Timmerman R, Tripuraneni P, Vlachaki M, Xing L, Rosenthal S: American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guidelines for image-guided radiation therapy (IGRT). Int J RadiatOncolBiol Phys. 76(2):319-325, 2010
  3. Foster R, Li H, Kerkhoff A, Enke C, Willoughby T, Kupelian PA, Solberg T: Comparison of transabdominal ultrasound and electromagnetic transponders for prostate localization. J ApplClin Med Phys. 6;11(1):2924, 2010
  4. Joensuu G, Joensuu T, Nokisalmi P, Reddy C, Isola J, Ruutu M, Kouri M, Kupelian PA, Collan J, Pesonen S,Hemminki A: A Phase I/II Trial of Gefitinib Given Concurrently with Radiotherapy in Patients with Nonmetastatic Prostate Cancer. Int J RadiatOncolBiolPhys.78(1):42-9, 2010.
  5. Colon J, Hsieh N, Ferguson A, Kupelian PA, Seal S, Jenkins D, Baker C: Cerium Oxide Nanoparticles Protect GastroIntestinal Epithelium from Radiation-Induced Damage by Reduction of ROS and Upregulation of Super Oxide Dismutase-2. Nanomedicine. 6(5):698-705, 2010
  6. Thames H, Kuban D, Levy L, Horwitz E, Kupelian PA, Martinez A, Michalski J, Pisansky T, Sandler H, Shipley W, Zelefsky M, Zietman A: The role of overall treatment time in the outcome of radiotherapy of prostate cancer: An analysis of biochemical failure in 4839 men treated between 1987 and 1995. RadiotherOncol. 96(1):6-12, 2010
  7. Zeidan O, Sriprisan S, Lopatiuk-Tirpak O, Kupelian PA, Meeks S, Hsi W, Li Z, Palta J, Maryanski M: Dosimetric evaluation of a novel polymer gel dosimeter for proton therapy. Med Phys. 37(5):2145-52. 2010
  8. Min Y, Santhanam A, Neelakkantan H, Ruddy B, Meeks S, Kupelian PA: A GPU-based framework for modeling real-time 3D lung tumor conformal dosimetry with subject-specific lung tumor motion. Phys Med Biol.55(17):5137-50. 2010
  9. Santhanam AP, Neelakkantan H, Min Y, Papp N, Bhargava A, … , Ilegbusi O, Ruddy H, Rolland P, Meeks L, Kupelian PA: Visualization of 3D Volumetric Lung Dynamics for Real-Time External Beam Lung Radiotherapy. Stud Health Technol Inform. 163:567-73, 2011
  10. Shah A, Kupelian PA, Willoughby T, Langen K, Meeks S: An evaluation of intrafraction motion of the prostate in the prone and supine positions using electromagnetic tracking. RadiotherOncol. 99(1):37-43, 2011.
  11. Tendulkar R, Reddy C, Stephans K, Ciezki J, Klein E, Mahadevan A, Kupelian PA: Redefining High-risk Prostate Cancer Based on Distant Metastases and Mortality After High-dose Radiotherapy with Androgen Deprivation Therapy. Int J RadiatOncolBiol Phys. 82(4): 1397-404, 2011
  12. Shah A, Kupelian PA, Willoughby T, Meeks S: Expanding the use of real-time electromagnetic tracking in radiation oncology. J ApplClin Med Phys. 2011 Nov 15;12(4):3590
  13. Smeenk R, Louwe R, Langen K, Shah A, Kupelian PA, van Lin E, Kaanders J: An Endorectal Balloon Reduces Intrafraction Prostate Motion During Radiotherapy. Int J RadiatOncolBiol Phys. 2012 Jun 1;83(2):661-9
  14. Zumsteg Z, Demarco J, Lee S, Steinberg M, Lin C, McBride W, Lin K, Wang P, Kupelian PA, Lee P: Image Guidance During Head-and-Neck Cancer Radiation Therapy: Analysis of Alignment Trends with In-Room Cone-Beam Computed Tomography Scans. Int J RadiatOncolBiol Phys. 2012 Jun 1;83(2):712-9
  15. Litzenberg D, Balter J, Hadley S, Hamstra D, Willoughby T, Kupelian PA, Djemil T, Mahadevan A, Jani S, Weinstein G, Solberg T, Enke C, Levine L, Sandler H. Prostate Intrafraction Translation Margins for Real-Time Monitoring and Correction Strategies. Prostate Cancer. 2012, epub, In press
  16. Grimm P, Billiet I, Bostwick D, Dicker A, Frank S, Immerzeel J, Keyes M, Kupelian PA, Lee W, Machtens S, Mayadev J, Moran B, Merrick G, Millar J, Roach M, Stock R, Shinohara K, Scholz M, Weber E, Zietman A, Zelefsky M, Wong J, Wentworth S, Vera R, Langley S. Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group. BJU Int. 109 Suppl 1:22-9, 2012
  17. Ruan D, Shao W, Demarco J, Tenn S, King C, Low D, Kupelian PA,Steinberg M: Evolving treatment plan quality criteria from institution specific experience. Med Phys. 39(5):2708-12. 2012
  18. Ilegbusi O, Li Z, Min Y, Meeks S, Kupelian PA, Santhanam A. Computational fluid dynamics modeling of airflow inside lungs using heterogenous anisotropic lung tissue elastic properties. Stud Health Technol Inform. 173:205-11, 2012
  19. Langen KM, Chauhan B, Siebers JV, Moore J, Kupelian PA. The Dosimetric Effect of Intrafraction Prostate Motion on Step-and-Shoot Intensity-Modulated Radiation Therapy Plans: Magnitude, Correlation With Motion Parameters, and Comparison With Helical Tomotherapy Plans. Int J RadiatOncolBiol Phys. 84(5):1220-5, 2012
  20. Hunter GK, Reddy CA, Klein EA, Kupelian PA, Angermeier K, Ulchaker J, Chehade N, Altman A, Ciezki J. Long-term (10-year) gastrointestinal and genitourinary toxicity after treatment with external beam radiotherapy, radical prostatectomy, or brachytherapy for prostate cancer. Prostate Cancer. 2012, epub, In press.
  21. Santhanam AP, Min Y, Neelakkantan H, Papp N, Meeks SL, Kupelian PA. A multi-GPU real-time dose simulation software framework for lung radiotherapy. Int J Comput Assist Radiol Surg. 7(5):705-19, 2012
  22. Lee P, Kupelian PA, Czernin J, Ghosh P. Current concepts in F18 FDG PET/CT-based radiation therapy planning for lung cancer. Front Oncol. 2012;2:71, 2012.
  23. P.Ciezki J, Reddy C, Kupelian PA, Klein E. Effect of Prostate-specific Antigen Screening on Metastatic Disease Burden 10 Years After Diagnosis. Urology,80(2):367-72, 2012.
  24. Dong P, Lee P, Dan R, Long T, Romeijn E, Yang Y, Low D, Kupelian PA, Sheng K. Non-Coplanar Liver SBRT: A Novel Delivery Technique. Int J RadiatOncolBiol Phys. 85(5):1360-6, 2013
  25. Kamrava M, Chung M, Kayode O, Wang J, Marks L, Kupelian PA, Steinberg M, Park S, Demanes D. Focal high-dose-rate brachytherapy: A dosimetric comparison of hemigland vs. conventional whole-gland treatment. Brachytherapy.Epub 2013
  26. Santhanam A, Dou T, Neylon J, Min Y, Kupelian A, Sheng K, Ennis D, Rolland J, Low D, Kupelian PA. Multi-scale, multi-modal image integration for image-guided clinical interventions in the head and neck anatomy. Stud Health Technol Inform. 184:380-6, 2013
  27. Ilegbusi O, Li Z, Seyfi B, Min Y, Meeks S, Kupelian PA,Santhanam A.
    Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models. Int J Biomed Imaging.2012:350853, 2012
  28. Santhanam A, Min Y, Dou T, Kupelian PA, Low D. A client-server framework for 3D remote visualization of radiotherapy treatment space. Front Oncol. 3:18, 2013
  29. Qi X, Hu A, Lee S, Lee P, Demarco J, Li X, Steinberg M, Kupelian PA, Low D. Assessment of Interfraction Patient Setup for Head-and-Neck Cancer Intensity Modulated Radiation Therapy Using Multiple Computed Tomography-Based Image Guidance. Int J RadiatOncolBiol Phys. 86(3):432-9, 2013
  30. Lee P, Eppinga W, Lagerwaard F, Cloughesy T, Slotman B, Nghiemphu P, Wang P, Kupelian PA, Agazaryan N, Demarco J, Selch M, Steinberg M, Kang J. Evaluation of High IpsilateralSubventricular Zone Radiation Therapy Dose in Glioblastoma: A Pooled Analysis. Int J RadiatOncolBiol Phys. 86(4):609-15, 2013.
  31. Shah A, Kupelian PA,Waghorn B, Willoughby T, Rineer J, Mañon R, Vollenweider M, Meeks S. Real-Time Tumor Tracking in the Lung Using an Electromagnetic Tracking System. Int J RadiatOncolBiol Phys. 86(3):477-83, 2013. Dong P, Lee P, Ruan D, Long T, Romeijn E, Low DA, Kupelian PA, Abraham J, Yang Y, Sheng K. 4π Noncoplanar Stereotactic Body Radiation Therapy for Centrally Located or Larger Lung Tumors. Int J RadiatOncolBiol Phys. 85(5):1360-6, 2013.
  32. Tendulkar R, Hunter G, Reddy C, Stephans K, Ciezki J, Abdel-Wahab M, Stephenson A, Klein E, Mahadevan A, Kupelian PA. Causes of mortality after dose-escalated radiotherapy and androgen deprivation for high risk prostate cancer. International Journal of Radiation Oncology, Biology, Physics. 87(1):94-9, 2013.
  33. Demarco J, Kupelian PA, Santhanam A, Low D.Shielding implications for secondary neutrons and photons produced within the patient during IMPT. Med Phys. 2013 Jul;40(7):071701
  34. Mesko S, Kupelian PA, Demanes DJ, Huang J, Wang PC, Kamrava M. Quantifying the ki-67 heterogeneity profile in prostate cancer. Prostate Cancer. 2013;2013:717080
  35. King CR, Collins S, Fuller D, Wang PC, Kupelian PA, Steinberg M, Katz A. Health-Related Quality of Life After Stereotactic Body Radiation Therapy for Localized Prostate Cancer: Results From a Multi-institutional Consortium of Prospective Trials. Int J RadiatOncolBiol Phys. 87(5):939-45, 2013
  36. King CR, Freeman D, Kaplan I, Fuller D, Bolzicco G, Collins S, Meier R, Wang J, Kupelian PA, Steinberg M, Katz A. Stereotactic body radiotherapy for localized prostate cancer: Pooled analysis from a multi-institutional consortium of prospective phase II trials.RadiotherOncol. 109(2):217-21,2013
  37. Sarma M, Hu P, Rapacchi S, Ennis D, Thomas A, Lee P, Kupelian PA, Sheng K.Accelerating Dynamic Magnetic Resonance Imaging (MRI) for Lung Tumor Tracking Based on Low-Rank Decomposition in the Spatial-Temporal Domain: A Feasibility Study Based on Simulation and Preliminary Prospective Undersampled MRI. Int J RadiatOncolBiol Phys. 88(3):723-31, 2014
  38. Min Y, Neylon J, Shah A, Meeks S, Lee P, Kupelian PA, Santhanam AP. 4D-CT Lung registration using anatomy-based multi-level multi resolution optical flow analysis and thin-plate splines. Int J Comput Assist Radiol Surg. 2014. Epub ahead of print
  39. Kamrava M, Chung M, Mesko S, Wang J, Raman S, Margolis D, Marks L, Kupelian PA. Correlation of Quantitative Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Parameters With NCCN Risk
    Group, Gleason Score, and Maximum Tumor Diameter in Prostate Cancer. PractRadiatOncol. Apr-Jun; 3 (2 Suppl 1): S4. 2013
  40. Anderson E, Margolis D, Mesko S, Banerjee R, Wang P, Demanes D, Kupelian PA, Kamrava M. Multiparametric MRI identifies and stratifies prostate cancer lesions: Implications for targeting intraprostatic targets. Brachytherapy. 13(3):292-8, 2014
  41. Santhanam A, Eldredge J, Benharash P, Teran J, Kupelian PA, Dutson E. Cardiovascular blood flow analysis under normal and open injury conditions. Stud Health Technol Inform. 196:372-7. 2014
  42. Kim D, Cho LC, Straka C, Christie A, Lotan Y, Pistenmaa D, Kavanagh B, Nanda A, Kupelian PA, Brindle J, Cooley S, Perkins A, Raben D, Xie X, Timmerman R. Predictors of rectal tolerance observed in a dose-escalated phase 1-2 trial of stereotactic body radiation therapy for prostate cancer. Int J RadiatOncolBiol Phys. 2014;89(3):509-17
  43. Santhanam A, Benharash P, Frank P, White B, Min Y, Ennis D, Kupelian PA, Dutson E. A framework for modeling and visualizing cardiovascular deformation under normal and altered circulatory conditions. Stud Health Technol Inform. 196:378-83. 2014
  44. Chung M, Margolis D, Mesko S, Wang J, Kupelian PA, Kamrava M. Correlation of quantitative diffusion-weighted and dynamic contrast-enhanced MRI parameters with prognostic factors in prostate cancer. J Med Imaging RadiatOncol. 2014
  45. Dong P, Nguyen D, Ruan D, King C, Long T, Romeijn E, Low D, Kupelian PA, Steinberg M, Yang Y, Sheng K. Feasibility of prostate robotic radiation therapy on conventional C-arm linacs. PractRadiatOncol. 4(4):254-60, 2014
  46. Neylon J, Sheng K, Yu V, Chen Q, Low D, Kupelian PA, Santhanam A. A nonvoxel-based dose convolution/superposition algorithm optimized for scalable GPU architectures. Med Phys. 2014 Oct;41(10):101711
  47. Nguyen D, Rwigema J, Yu V, Kaprealian T, Kupelian PA, Selch M, Lee P, Low DA, Sheng K. Feasibility of extreme dose escalation for glioblastomamultiforme using 4¿ radiotherapy. RadiatOncol. 7;9(1):239, 2014
  48. Kim D, Cho L, Straka C, Christie A, Lotan Y, Pistenmaa D, Kavanagh B, Nanda A, Kupelian PA, Brindle J, Cooley S, Perkins A, Raben D, Xie X, Timmerman R. Predictors of rectal tolerance observed in a dose-escalated phase 1-2 trial of stereotactic body radiation therapy for prostate cancer. Int J RadiatOncolBiol Phys. 89(3):509-17. 2014
  49. Kupelian PA, Mehta N, King C, Steinberg M, Finkelstein S, Fernandez E. Stereotactic body radiation therapy for prostate cancer: Rational and reasonable. PractRadiatOncol. 2014, In Press
  50. Rwigema J, King C, Wang P, Kamrava M, Kupelian PA, Steinberg M, Lee P. Stereotactic body radiation therapy for abdominal and pelvic oligometastases: Dosimetric targets for safe and effective local control. PractRadiatOncol. 2014, In Press
  51. Rwigema J, Nguyen D, Heron DE, Chen AM, Lee P, Wang P, Vargo J, Low D, Huq M, Tenn S, Steinberg M, Kupelian PA, Sheng K. 4π Noncoplanar Stereotactic Body Radiation Therapy for Head-and-Neck Cancer: Potential to Improve Tumor Control and Late Toxicity. Int J RadiatOncolBiol Phys. 2014, In Press
  52. Kishan AU, Kupelian PA. Late rectal toxicity after low-dose-rate brachytherapy: Incidence, predictors, and management of side effects. Brachytherapy. 2014, In Press
  53. Neylon J, Qi X, Sheng K, Staton R, Pukala J, Manon R, Low DA, Kupelian P, Santhanam A. A GPU based high-resolution multilevel biomechanical head and neck model for validating deformable image
    registration. Med Phys. 2015 Jan;42(1):232, 2015