Study of Dietary Composition in Crohn's Disease
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.
- Age of 18 to 75 years old
- History of Crohn's Disease (CD) with mild to moderate symptoms and prior biopsy proof
- History or current diagnosis of any of the following:
- Stroke or Arrhythmia
- Liver Disease
- Untreated hypertension (High Blood Pressure)
- Active malignancy
- Bleeding disorders
- Heart Disease
- Lung disease
- Previous Heart surgery
- Previous Gastrointestinal Surgery
- Kidney Disease
- Chronic Diarrhea
- End enterostomy
- Laxative Abuse
- Endocrine Disorder
- Current history of smoking tobacco
- Urgent need for abdominal sugery
- Severe Malnutrition
- Active alcohol or non-cannabinoid substance abuse
- Recent hospitalization within the last 30 days
- Currently pregnant of lactating.
- Current use probiotics or dietary supplements that would not be willing to discontinue for the length of the study.
- Concerns for non-compliance
- If currently on immunosuppressants, immunomodulators, cotticosteroids, and/or 5-aminosalicylates, no changes in doses will be permitted during the trial except for tapering of corticosteroids.