Study of Dietary Composition in Crohn's Disease

About

Brief Summary

Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.

Primary Purpose

Prevention

Study Type

Interventional

Phase

Phase 3

Eligibility

Gender

All

Healthy Volunteers

No

Minimum Age

18 Years

Maximum Age

75 Years

Inclusion Criteria:

Age of 18 to 75 years old
History of Crohn's Disease (CD) with mild to moderate symptoms and prior biopsy proof

Exclusion Criteria:

History or current diagnosis of any of the following:
- Stroke or Arrhythmia
- Seizures
- Liver Disease
- Untreated hypertension (High Blood Pressure)
- Active malignancy
- Bleeding disorders
- Heart Disease
- Lung disease
- Previous Heart surgery
- Previous Gastrointestinal Surgery
- Kidney Disease
- Chronic Diarrhea
- End enterostomy
- Bulimia
- Anorexia
- Laxative Abuse
- Endocrine Disorder
- Current history of smoking tobacco
- Urgent need for abdominal sugery
- Severe Malnutrition
- Active alcohol or non-cannabinoid substance abuse
Recent hospitalization within the last 30 days
Currently pregnant of lactating.
Current use probiotics or dietary supplements that would not be willing to discontinue for the length of the study.
Concerns for non-compliance
If currently on immunosuppressants, immunomodulators, cotticosteroids, and/or 5-aminosalicylates, no changes in doses will be permitted during the trial except for tapering of corticosteroids.