Select Publications
Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RMB, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR and Modlin RL. IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci Transl Med 20 August 2014: Vol. 6, Issue 250, p. 250ra114. Link »
Modlin RL, Bloom BR, TB or Not TB: That Is No Longer the Question. Sci. Transl. Med. 5, 213sr6 (2013). Link »
Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin, RL. Type I interferon suppresses Type II interferon-triggered human anti-mycobacterial responses. Science. doi: 10.1126/science.1233665, 2013. Link »
Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, Modlin RL, Miller JF, Sodergren E, Craft N, Weinstock GM, Li H. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. doi: 10.1038/jid.2013.21, 2013. PMID: 23337890.
Klug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M. CD40L and IFN-γ induce an antimicrobial response against M. tuberculosis in human monocytes. Immunology. doi:10.1111/imm.12062, 2013. PMID: 23289765.
Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J. Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: A targeted therapy for cutaneous pathogens. J Invest Dermatol. doi: 10.1038/jid.2012.399, 2012. PMID: 23190896.
Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Stenger S, Modlin RL, Lee DJ. Galectin-3 regulates the innate immune response of human monocytes. J Infect Dis. 207(6):947-56, 2012. PMID: 23255567.
Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer S, Zaver, Schenk M, Zeng S, Zhong W, Liu Z, Modlin RL, Liu Y, Cheng G. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol. 13:1155-61, 2012. PMID: 23142775.
Jacobs-Sera D, Marinelli LJ, Bowman C, Broussard GW, Guerrero Bustamante C, Boyle MM, Petrova ZO, Dedrick RM, Pope WH, Science Education Alliance Phage Hunters Advancing Genomics And Evolutionary Science Sea-Phages Program, Modlin RL, Hendrix RW, Hatfull GF. On the nature of mycobacteriophage diversity and host preference. Virology. 434:187-201, 2012. PMID: 23084079.
Marinelli LJ, Fitz-Gibbon S, Hayes C, Bowman C, Inkeles M, Loncaric A, Russell DA, Jacobs-Sera D, Cokus S, Pellegrini M, Kim J, Miller JF, Hatfull GF, Modlin RL. Propionibacterium acnes Bacteriophages Display Limited Genetic Diversity and Broad Killing Activity against Bacterial Skin Isolates. MBio. 3:e00279-12, 2012. PMID: 23015740, PMCID: PMC3448167.
Bruns H, Stegelmann F, Fabri M, Döhner K, van Zandbergen G, Wagner M, Skinner M, Modlin RL, Stenger S. Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacteriumtuberculosis in Human Macrophages. J Immunol. 189:4069-78, 2012. PMID: 22988030.
Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M. Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood. 18:3699-707, 2012. PMID: 22927244, PMCID: PMC3488884.
Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 22:1118-27, 2012. PMID: 22534567, PMCID: PMC3382347.
Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. NOD2 triggers an IL-32 dependent human dendritic cell program in leprosy. Nat Med. 18:555-63, 2012. PMID: 22447076, PMCID: PMC3348859.
Hou W, Gibbs JS, Lu X, Brooke CB, Roy D, Modlin RL, Bennink JR, Yewdell JW. Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells. Blood. 119:3128-31, 2012. PMID: 22310910, PMCID: PMC3321872.
Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 18:267-73, 2012. PMID: 22286305, PMCID: PMC3274599.
Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MV, Stenger S, Modlin RL, Schlesinger LS. Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses. J Biol Chem. 286:35438-46, 2011. PMID: 21859718, PMCID: PMC3195570.
Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages. Sci Transl Med. 12:104ra102, 2011. PMID: 21998409. PMCID: PMC3269210.
Walker VP, Zhang X, Rastegar I, Liu PT, Hollis BW, Adams JS, Modlin RL. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab. 96:1835-43, 2011. PMID: 21470993, PMCID: PMC3100757.
Cruz D, Wang Z, Kibbie J, Modlin R, Kwon O. Organic synthesis toward small-molecule probes and drugs special feature: Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity. Proc Natl Acad Sci USA. PNAS. 108:6769-74, 2011. PMID: 21383121, PMCID: PMC3084088.
Cho JS, Zussman J, Donegan NP, Ramos RI, Garcia NC, Uslan DZ, Iwakura Y, Simon SI, Cheung AL, Modlin RL, Kim J, Miller LS. Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections. J Invest Dermatol. 131:907-15, 2011. PMID: 21191403, PMCID: PMC3059384.
Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci. 107:22593-8, 2010. PMID: 21149724, PMCID: PMC3012480.
Teles RM, Krutzik SR, Ochoa MT, Oliveira RB, Sarno EN, Modlin RL. IL-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Infect Immun. 78:4634-43, 2010. PMID: 20713631, PMCID: PMC2976321.
Shin DM, Yuk JM, Lee HM, Lee SH, Son JW, Harding CV, Kim JM, Modlin RL, Jo EK. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell Microbol. 12:1648-65, 2010. PMID: 20560977, PMCID: PMC2970753.
Ochoa MT, Teles RM, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ. A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy. Immunology. 131:405–14, 2010. PMID: 20561085, PMCID: PMC2996561.
Chun RF, Lauridsen AL, Suon L, Zella LA, Pike JW, Modlin RL, Martineau AR, Wilkinson RJ, Adams J, Hewison M. Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J Clin Endocrin Metab. 95:1-9, 2010. PMID: 20427486, PMCID: PMC2928899.
Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL, Integrated pathways for neutrophil recruitment and inflammation in leprosy., J Infect Dis, 2010, 201 (4), 558-69.
Modlin RL., The innate immune response in leprosy, Curr Opin Immunol., 2010, 22 (1), 48-54.
Montoya Dennis, Cruz Daniel, Teles Rosane M B, Lee Delphine J, Ochoa Maria Teresa, Krutzik Stephan R, Chun Rene, Schenk Mirjam, Zhang Xiaoran, Ferguson Benjamin G, Burdick Anne E, Sarno Euzenir N, Rea Thomas H, Hewison Martin, Adams John S, Cheng Genhong, Modlin Robert L, Divergence of macrophage phagocytic and antimicrobial programs in leprosy., Cell host & microbe, 2009, 6 (4), 343-53. Link »
Fabri M, Modlin RL., A vitamin for autophagy, Cell Host Microbe., 2009, 6 (3), 201-3.
Tanaka M, Krutzik SR, Sieling PA, Lee DJ, Rea TH, Modlin RL, Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses, J Immunol. , 2009, 183 (4), 2349-55.
Bruns H, Meinken C, Schauenberg P, Härter G, Kern P, Modlin RL, Antoni C, Stenger S., Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans, J Clin Invest., 2009, 119 (5), 1167-77.
Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL., Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses, PLoS One., 2009, 4 (6).
Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT, Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K, J Immunol., 2009, 183 (1), 491-8.
Modlin RL, Brenner MB., T cell responses in microbial infection, Curr Opin Immunol., 2009, 21 (4), 365-6.
Schenk M, Belisle JT, Modlin RL., TLR2 looks at lipoproteins., Immunity, 2009, 31 (6), 847-9.
Walker VP, Modlin RL., The vitamin D connection to pediatric infections and immune function, Pediatr Res. , 2009, 65, 106R-113R.
Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M., Vitamin d-directed rheostatic regulation of monocyte antibacterial responses, J Immunol., 2009, 182 (7), 4289-95.
Ochoa MT, Loncaric A, Krutzik SR, Becker TC, Modlin RL, "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages, J Invest Dermatol., 2008, 128 (9), 2225-31.
Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL., Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation, J Immunol., 2008, 180 (9), 5833-42.
Lee DJ, Modlin RL., DNA transportation authority, Nat Med., 2008, 14 (12), 1319-20.
Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL., Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy, J Clin Invest. , 2008, 118 (8), 2917-28.
Liu PT, Modlin RL., Human macrophage host defense against Mycobacterium tuberculosis, Curr Opin Immunol., 2008, 20 (4), 371-6.
Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, Modlin RL., IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway, J Immunol., 2008, 181 (10), 7115-20.
Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL, Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences, Immunology, 2007, 122 (4), 522-31.
Bhandarkar SS, Cohen C, Kuruvila M, Rea TH, Mackelfresh JB, Lee DJ, Modlin RL, Arbiser JL., Angiogenesis in cutaneous lesions of leprosy: implications for treatment, Arch Dermatol., 2007, 143 (12), 1527-9.
Di Nardo A, Braff MH, Taylor KR, Na C, Granstein RD, McInturff JE, Krutzik S, Modlin RL, Gallo RL., Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization, J Immunol., 2007, 178 (3), 1829-34.
Liu PT, Stenger S, Tang DH, Modlin RL., Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin, J Immunol., 2007, 179 (4), 2060-3.
Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P, Modlin RL, Adams JS., Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease, J Steroid Biochem Mol Biol. , 2007, 103 (3-5), 316-21.
Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL., Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion, Immunology, 2007, 120 (3), 354-61.
Miller LS, Modlin RL., Human keratinocyte Toll-like receptors promote distinct immune responses, J Invest Dermatol., 2007, 127 (2), 262-3.
Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL., Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo, J Immunol., 2007, 179 (10), 6933-42.
Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL., Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism, J Clin Invest., 2007, 117 (3), 803-11.
Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, Modlin RL, Liblau RS, Gressner AM, Kaufmann SH., Ito cells are liver-resident antigen-presenting cells for activating T cell responses, Immunity, 2007, 26 (1), 117-29.
Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL., LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells, J Immunol., 2007, 179 (12), 8128-36.
Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL., Regulation of human T-cell homing receptor expression in cutaneous bacterial infection, Immunology, 2007, 120 (4), 518-25.
Adams JS, Chen H, Chun R, Ren S, Wu S, Gacad M, Nguyen L, Ride J, Liu P, Modlin R, Hewison M., Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response, J Bone Miner Res., 2007, 22 (2), V20-4.
Liu PT, Krutzik SR, Modlin RL., Therapeutic implications of the TLR and VDR partnership, Trends Mol Med. , 2007, 13 (3), 117-24.
Miller LS, Modlin RL., Toll-like receptors in the skin, Semin Immunopathol., 2007, 29 (1), 15-26.
Adams JS, Liu PT, Chun R, Modlin RL, Hewison M., Vitamin D in defense of the human immune response, Ann N Y Acad Sci. , 2007, 1117, 94-105.
Liu Philip T, Stenger Steffen, Li Huiying, Wenzel Linda, Tan Belinda H, Krutzik Stephan R, Ochoa Maria Teresa, Schauber Jurgen, Wu Kent, Meinken Christoph, Kamen Diane L, Wagner Manfred, Bals Robert, Steinmeyer Andreas, Z????gel Ulrich, Gallo Richard L, Eisenberg David, Hewison Martin, Hollis Bruce W, Adams John S, Bloom Barry R, Modlin Robert L, Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response., Science, 2006, 311 (5768), 1770-3. Link »
Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G., A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections, J Exp Med. , 2006, 203 (12), 2589-602.
Im JS, Tapinos N, Chae GT, Illarionov PA, Besra GS, DeVries GH, Modlin RL, Sieling PA, Rambukkana A, Porcelli SA., Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells, J Immunol. , 2006, 177 (8), 5226-35.
Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED., Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation, J Immunol., 2006, 176 (6), 3536-47.
Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S., Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens, J Immunol. , 2006, 177 (3), 1864-71.
Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL., TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response, J Immunol. , 2006, 177 (1), 298-305.
Krutzik Stephan R, Tan Belinda, Li Huiying, Ochoa Maria Teresa, Liu Philip T, Sharfstein Sarah E, Graeber Thomas G, Sieling Peter A, Liu Yong-Jun, Rea Thomas H, Bloom Barry R, Modlin Robert L, TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells., Nat. Med., 2005, 11 (6), 653-60. Link »
Lee DJ, Modlin RL., Breaking tolerance--another piece added to the vitiligo puzzle, J Invest Dermatol., 2005, 124 (1), xiii-xv.
Stegelmann F, Bastian M, Swoboda K, Bhat R, Kiessler V, Krensky AM, Roellinghoff M, Modlin RL, Stenger S., Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis, J Immunol. , 2005, 175 (11), 7474-83.
Liu PT, Krutzik SR, Kim J, Modlin RL., Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function, J Immunol., 2005, 174 (5), 2467-70.
McInturff JE, Wang SJ, Machleidt T, Lin TR, Oren A, Hertz CJ, Krutzik SR, Hart S, Zeh K, Anderson DH, Gallo RL, Modlin RL, Kim J., Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes, J Invest Dermatol., 2005, 125 (2), 256-63.
Modlin RL, Sieling PA., Immunology. Now presenting: gammadelta T cells, Science., 2005, 309 (5732), 252-3.
Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL., TGF-alpha regulates TLR expression and function on epidermal keratinocytes, J Immunol., 2005, 174 (10), 6137-43.
Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, Modlin RL., The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens, J Immunol. , 2005, 174 (5), 2637-44.
McInturff JE, Modlin RL, Kim J., The role of toll-like receptors in the pathogenesis and treatment of dermatological disease, J Invest Dermatol., 2005, 125 (1), 1-8.
Modlin RL, Cheng G., From plankton to pathogen recognition, Nat Med., 2004, 10 (11), 1173-4.
Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL., Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells, J Clin Invest. , 2004, 113 (5), 701-8.
Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE., Saposin C is required for lipid presentation by human CD1b, Nat Immunol., 2004, 5 (2), 169-74.
Krutzik SR, Modlin RL., The role of Toll-like receptors in combating mycobacteria, Semin Immunol., 2004, 16 (1), 35-41.
Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G., Toll-like receptors induce a phagocytic gene program through p38, J Exp Med., 2004, 199 (1), 81-90.
Torrelles JB, Khoo KH, Sieling PA, Modlin RL, Zhang N, Marques AM, Treumann A, Rithner CD, Brennan PJ, Chatterjee D., Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis, J Biol Chem., 2004, 279 (39), 41227-39.
Bleharski Joshua R, Li Huiying, Meinken Christoph, Graeber Thomas G, Ochoa Maria-Teresa, Yamamura Masahiro, Burdick Anne, Sarno Euzenir N, Wagner Manfred, Röllinghoff Martin, Rea Thomas H, Colonna Marco, Stenger Steffen, Bloom Barry R, Eisenberg David, Modlin Robert L, Use of genetic profiling in leprosy to discriminate clinical forms of the disease., Science (New York, N.Y.), 2003, 301 (5639), 1527-30. Link »
Krutzik Stephan R, Ochoa Maria Teresa, Sieling Peter A, Uematsu Satoshi, Ng Yolanda W, Legaspi Annaliza, Liu Philip T, Cole Stewart T, Godowski Paul J, Maeda Yumi, Sarno Euzenir N, Norgard Michael V, Brennan Patrick J, Akira Shizuo, Rea Thomas H, Modlin Robert L, Activation and regulation of Toll-like receptors 2 and 1 in human leprosy., Nature medicine, 2003, 9 (5), 525-32. Link »
Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, Modlin RL., A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response, J Immunol., 2003, 170 (7), 3812-8.
Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL., Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2, J Immunol., 2003, 171 (12), 6820-6.
Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, Modlin RL, Brinkmann V, Kaufmann SH., Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis, Nat Med., 2003, 9 (8), 1039-46.
Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL., Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy, Infect Immun. , 2003, 71 (3), 1427-33.
Gansert JL, Kiessler V, Engele M, Wittke F, Röllinghoff M, Krensky AM, Porcelli SA, Modlin RL, Stenger S., Human NKT cells express granulysin and exhibit antimycobacterial activity, J Immunol., 2003, 170 (6), 3154-61.
Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K., PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4, J Biol Chem., 2003, 278 (24), 21327-30.
Hertz CJ, Modlin RL., Role of toll-like receptors in response to bacterial infection, Contrib Microbiol., 2003, 10, 149-63.
Walton KA, Cole AL, Yeh M, Subbanagounder G, Krutzik SR, Modlin RL, Lucas RM, Nakai J, Smart EJ, Vora DK, Berliner JA., Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2, Arterioscler Thromb Vasc Biol., 2003, 23 (7), 1197-203.
Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL., Toll-like receptor 2 ligands as adjuvants for human Th1 responses, J Immunol., 2003, 170 (1), 194-200.
Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL., Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses, J Immunol. , 2002, 169 (3), 535-41.
Stenger S, Modlin RL., Control of Mycobacterium tuberculosis through mammalian Toll-like receptors, Curr Opin Immunol. , 2002, 14 (4), 452-7.
Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S., Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins, J Immunol., 2002, 169 (1), 10-4.
Modlin RL., Learning from leprosy: insights into contemporary immunology from an ancient disease, Skin Pharmacol Appl Skin Physiol. , 2002, 15 (1), 1-6.
Modlin RL., Mammalian toll-like receptors, Ann Allergy Asthma Immunol., 2002, 88 (6), 543-7.
Niazi KR, Porcelli SA, Modlin RL., The CD1b structure: antigen presentation adapts to a high-fat diet, Nat Immunol. , 2002, 3 (8), 703-4.
Sieling PA, Modlin RL., Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders, Curr Opin Microbiol. , 2002, 5 (1), 70-5.
Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL, Induction of direct antimicrobial activity through mammalian toll-like receptors., Science. , 2001, 291 (5508), 1544-7.
Ochoa M T, Stenger S, Sieling P A, Thoma-Uszynski S, Sabet S, Cho S, Krensky A M, Rollinghoff M, Nunes Sarno E, Burdick A E, Rea T H, Modlin R L, T-cell release of granulysin contributes to host defense in leprosy., Nature Medicine, 2001, 7 (2), 174-9. Link »
Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL, Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors., Science. , 1999, 285 (5428), 732-6.
Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melin A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL, An antimicrobial activity of cytolytic T cells mediated by granulysin., Science. , 1998, 282 (5386), 121-5.
Modlin RL., Dermatology-Important Advances in Clinical Medicine: Kaposi's Sarcoma: Current Trends, West J Med. , 1983, 138 (6), 862-863.