Our Research

Aims: While several medical and surgical weight reduction strategies are available, with newer, transformative medications recently approved, little is known about their safety and effectiveness in clinical practice. This proposal’s goal is to develop, implement, and test approaches to produce large scale, high-quality evidence on the comparative safety and effectiveness of medical and surgical weight loss strategies in clinical practice. This work will develop more accurate, methodologically rigorous approaches to conduct real-world evidence studies of medical and surgical weight reduction strategies using large scale, real-world data and will create an invaluable infrastructure to conduct future studies on the comparative safety and effectiveness of various cardiometabolic treatments.

Funded by: National Institute of Diabetes and Digestive and Kidney Diseases

Aims: While the newer classes of diabetes medications have shown clinical benefits in patients with diabetic kidney disease (DKD) in randomized controlled trials, one of the major prescribing barriers is the lack of safety data in real-world patients with DKD, a complex, older population with multimorbidity and polypharmacy, who are at greater risk for adverse events and drug-drug interactions. This proposal’s goal is to develop a framework to optimize the safety of newer diabetes medications in real-world patients with DKD. This proposal will advance our understanding of these drugs’ safety and thus, will help overcome barriers to prescribing in patients with DKD who may largely benefit from them, greatly advancing the clinical care of patients with DKD.

Funded by: National Institute of Diabetes and Digestive and Kidney Diseases

Aims: To answer the question that most patients and their healthcare providers face when metformin is insufficient to manage hyperglycemia: “Which glucose-lowering medications should patients with type 2 diabetes with moderate cardiovascular disease and their providers add, to best balance tradeoffs in benefits and risks?”

​Funded by: Patient-Centered Outcomes Research Institute (PCORI)