Janel Le Belle, PhD
Janel Le Belle, PhD
Associate Adjunct Professor
Academic Affiliation
David Geffen School of Medicine at UCLA
Department of Neurosurgery
PO Box 956901
Los Angeles, CA 90095-6901
Contact: (310) 983-3486
[email protected]
EDUCATION
- Ph.D., Biochemistry, University College London, 1995-1999
- B.A, Philosophy, Neuroscience, University of Florida, 1990-1995
RESEARCH AREA
Dr. Le Belle is an adjunct associate professor faculty member with expertise in stem cell biology, exogenous and endogenous cellular brain repair following injury, fatty acid metabolism, signaling, and regulation of neural stem cells in the aging brain and in glioma stem cells, and the effects of neuroinflammation on brain development, neural stem cell function, and neurogenesis. She has worked for several years on the etiology of brain overgrowth, abnormal sensory processing, and abnormal behaviors in neurodevelopmental mouse models. Her lab is currently funded to research the shared brain functional circuitry, physiological (heart) responses, and cognitive function in mice and humans with sensory over-responsivity and post-concussion sensory hyper-sensitivity to identify if there are convergent mechanisms between disorders and across species. The lab is also pursuing research on the effects of neuro-inflammatory risk factors like Diabetes and prior Covid infections on sensory, motor, and cognitive outcomes following repeat concussion injury. Dr. Le Belle teaches Neuroanatomy, Neurophilosophy, and Stem Cell Biology classes on campus. She has both a research and academic interest in furthering our understanding of human consciousness and conscious sensory experience and interoception.
LINKS
https://www.uclahealth.org/departments/neurosurgery
PUBLICATIONS (recent articles)
JE Le Belle, NM Orozco, AA Paucar, JP Saxe, J Mottahedeh, AD Pyle, ... Cell stem cell 8 (1), 59-71 | 2011 |
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry M Groszer, R Erickson, DD Scripture-Adams, JD Dougherty, J Le Belle, ... Proceedings of the National Academy of Sciences 103 (1), 111-116 | 2006 |
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis C Gregorian, J Nakashima, J Le Belle, J Ohab, R Kim, A Liu, KB Smith, ... Journal of Neuroscience 29 (6), 1874-1886 | 2009 |
JE Le Belle, J Sperry, A Ngo, Y Ghochani, DR Laks, M López-Aranda, ... Stem cell reports 3 (5), 725-734 | 2014 |
Stem cells for neurodegenerative disorders: where can we go from here? JE Le Belle, CN Svendsen BioDrugs 16, 389-401 | 2002 |
Inosine promotes recovery of skilled motor function in a model of focal brain injury JM Smith, P Lunga, D Story, N Harris, J Le Belle, MF James, JD Pickard, ... Brain 130 (4), 915-925 | 2007 |
Improving the survival of human CNS precursor‐derived neurons after transplantation JE Le Belle, MA Caldwell, CN Svendsen Journal of neuroscience research 76 (2), 174-183 | 2004 |
J Sperry, MC Condro, L Guo, D Braas, N Vanderveer-Harris, KKO Kim, ... Iscience 23 (9) | 2020 |
Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone GM Thomsen, JE Le Belle, JA Harnisch, WS Mc Donald, DA Hovda, ... Stem cell research 13 (1), 48-60 | 2014 |
JE Le Belle, J Sperry, K Ludwig, NG Harris, MA Caldwell, HI Kornblum bioRxiv, 2020.02. 10.942870 | 2020 |
J Sperry, JE Le Belle, MC Condro, L Guo, D Braas, N Vanderveer-Harris, ... bioRxiv, 659474 | 2019 |
Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations JE Le Belle, HI Kornblum Neuron 101 (1), 1-2 | 2019 |
RBIO-06. NADPH oxidase (NOX) promotes radiation resistance through oxidation of pten in glioblastoma K Ludwig, J Le Belle, J Sperry, E Vlashi, F Pajonk, H Kornblum Neuro-Oncology 19 (Suppl 6), vi218 | 2017 |
JE Le Belle, NG Harris, SR Williams, KK Bhakoo NMR IN BIOMEDICINE 29 (4), 527-527 | 2016 |
A comparison of cell and tissue extraction techniques using high‐resolution 1H‐NMR spectroscopy JE Le Belle, NG Harris, SR Williams, KK Bhakoo NMR in Biomedicine 29 (4), 527-527 | 2016 |
K Ludwig, JE Le Belle, SD Muthukrishnan, J Sperry, M Condro, E Vlashi, ... Antioxidants & Redox Signaling 39 (13-15), 890-903 | 2023 |
NADPH oxidase promotes glioblastoma radiation resistance in a PTEN-dependent manner K Ludwig, JE Le Belle, SD Muthukrishnan, J Sperry, M Condro, E Vlashi, ... bioRxiv, 2022.06. 16.496502 | 2022 |
G Thomsen, J Le Belle, J Harnisch, D Hovda, H Kornblum, N Harris JOURNAL OF NEUROTRAUMA 28 (6), A80-A80 | 2011 |
G Miller, J Le Belle, D Hovda, H Kornblum, N Harris JOURNAL OF NEUROTRAUMA 26 (8), A6-A6 | 2009 |
G Miller, J Le Belle, D Hovda, H Kornblum, N Harris JOURNAL OF NEUROTRAUMA 25 (7), 921-921 | 2008 |