Dr. Le Belle

Janel Le Belle, PhD
Associate Adjunct Professor

Academic Affiliation
David Geffen School of Medicine at UCLA
Department of Neurosurgery
PO Box 956901
Los Angeles, CA 90095-6901

Contact: (310) 983-3486
[email protected]

EDUCATION

  • Ph.D., Biochemistry, University College London, 1995-1999
  • B.A, Philosophy, Neuroscience, University of Florida, 1990-1995

RESEARCH AREA

LINKS

https://www.uclahealth.org/departments/neurosurgery

PUBLICATIONS (recent articles)

Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner

JE Le Belle, NM Orozco, AA Paucar, JP Saxe, J Mottahedeh, AD Pyle, ...
Cell stem cell 8 (1), 59-71
2011

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

M Groszer, R Erickson, DD Scripture-Adams, JD Dougherty, J Le Belle, ...
Proceedings of the National Academy of Sciences 103 (1), 111-116
2006

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis

C Gregorian, J Nakashima, J Le Belle, J Ohab, R Kim, A Liu, KB Smith, ...
Journal of Neuroscience 29 (6), 1874-1886
2009

Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells

JE Le Belle, J Sperry, A Ngo, Y Ghochani, DR Laks, M López-Aranda, ...
Stem cell reports 3 (5), 725-734
2014

Stem cells for neurodegenerative disorders: where can we go from here?

JE Le Belle, CN Svendsen
BioDrugs 16, 389-401
2002

Inosine promotes recovery of skilled motor function in a model of focal brain injury

JM Smith, P Lunga, D Story, N Harris, J Le Belle, MF James, JD Pickard, ...
Brain 130 (4), 915-925
2007

Improving the survival of human CNS precursor‐derived neurons after transplantation

JE Le Belle, MA Caldwell, CN Svendsen
Journal of neuroscience research 76 (2), 174-183
2004

Glioblastoma utilizes fatty acids and ketone bodies for growth allowing progression during ketogenic diet therapy

J Sperry, MC Condro, L Guo, D Braas, N Vanderveer-Harris, KKO Kim, ...
Iscience 23 (9)
2020

Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone

GM Thomsen, JE Le Belle, JA Harnisch, WS Mc Donald, DA Hovda, ...
Stem cell research 13 (1), 48-60
2014

Docosahexaenoic Acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain

JE Le Belle, J Sperry, K Ludwig, NG Harris, MA Caldwell, HI Kornblum
bioRxiv, 2020.02. 10.942870
2020

Metabolism of fatty acids and ketone bodies for glioblastoma growth: Implications for Ketogenic Diet Therapy

J Sperry, JE Le Belle, MC Condro, L Guo, D Braas, N Vanderveer-Harris, ...
bioRxiv, 659474
2019

Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations

JE Le Belle, HI Kornblum
Neuron 101 (1), 1-2
2019

RBIO-06. NADPH oxidase (NOX) promotes radiation resistance through oxidation of pten in glioblastoma

K Ludwig, J Le Belle, J Sperry, E Vlashi, F Pajonk, H Kornblum
Neuro-Oncology 19 (Suppl 6), vi218
2017

A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy (vol 15, pg 37, 2002)

JE Le Belle, NG Harris, SR Williams, KK Bhakoo
NMR IN BIOMEDICINE 29 (4), 527-527
2016

A comparison of cell and tissue extraction techniques using high‐resolution 1H‐NMR spectroscopy

JE Le Belle, NG Harris, SR Williams, KK Bhakoo
NMR in Biomedicine 29 (4), 527-527
2016

Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent Manner

K Ludwig, JE Le Belle, SD Muthukrishnan, J Sperry, M Condro, E Vlashi, ...
Antioxidants & Redox Signaling 39 (13-15), 890-903
2023

NADPH oxidase promotes glioblastoma radiation resistance in a PTEN-dependent manner

K Ludwig, JE Le Belle, SD Muthukrishnan, J Sperry, M Condro, E Vlashi, ...
bioRxiv, 2022.06. 16.496502
2022

NON-PROLIFERATIVE EXPANSION OF SVZ ASTROCYTE AND ACTIVATED STEM CELL POPULATIONS OCCURS AS EGFR (+) CELLS BECOME LESS PROLIFERATIVE AFTER BRAIN INJURY

G Thomsen, J Le Belle, J Harnisch, D Hovda, H Kornblum, N Harris
JOURNAL OF NEUROTRAUMA 28 (6), A80-A80
2011

ENDOGENOUS SVZ NEURAL STEM AND PROGENITOR CELLS ARE STIMULATED TO DIVIDE AND GENERATE NEW CORTICAL CELLS FOLLOWING TRAUMATIC BRAIN INJURY

G Miller, J Le Belle, D Hovda, H Kornblum, N Harris
JOURNAL OF NEUROTRAUMA 26 (8), A6-A6
2009

Effect of traumatic brain injury on the normally quiescent population of neural stem cells in the adult mouse SVZ

G Miller, J Le Belle, D Hovda, H Kornblum, N Harris
JOURNAL OF NEUROTRAUMA 25 (7), 921-921
2008