Research: Roger S. Lo Laboratory at UCLA
The Roger S. Lo Laboratory addresses key challenges in the development of novel melanoma therapeutics:
- We have focused on how BRAF-mutant melanomas acquire late resistance to BRAF inhibitors and how the BRAF inhibitors induce secondary neoplasms.
- Our current research tackles layers of complexity during the evolution of resistance to targeting of a key melanoma-addicted oncogene such as BRAF. These complexities include signaling and epigenetic reprogramming, melanoma dormancy and the master-regulators of such melanoma phenotypic plasticity.
- We seek to also understand the functional interface between melanoma and its tumor-infiltrating neighboring cells, including immune-regulatory and immune cells.
- We look for therapeutic opportunities from our preclinical and clinical tissue correlative studies and promote clinical trial testing of novel therapeutic concepts.
Lo Laboratory In the News
Postdoctoral Fellows at Roger S. Lo Laboratory
We have two postdoctoral fellowships available in the Lo Laboratory, focused on melanoma research and bioinformatics.
Postdoctoral Fellow in Melanoma Research at Roger S. Lo Laboratory
This postdoctoral position is focused on melanoma research toward our understanding of the mechanisms of acquired resistance to targeted therapies (B-RAF inhibitors) using integrated genomics. We are affiliated with the Department of Medicine/Division of Dermatology, the Department of Molecular and Medical Pharmacology, and the Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program) at the University of California, Los Angeles.
The ideal candidate must have extensive experience handling RNA, DNA and protein. His or her skill set should include:
- Molecular cloning
- Immunohistochemistry
- Immunoprecipitation
- FACS analysis
- Immuno-blotting
- Mammalian cell culture
- Viral transduction
- Microscopy
- Small animal work
Interested individuals should have:
- Strength in bioinformatic skills, a significant advantage
- Fluency in English and strong written and oral communication skills: Prerequisites
- Permanent U.S. residency or citizenship: Preferred but not required
- At least one first-authored publication in a top-ranked, peer-reviewed journal
Postdoctoral Fellow in Bioinformatics
This position is available immediately in the Lo Laboratory, which is focused on melanoma research in the following thematic areas:
- Discovering somatically mutated genes in melanoma using exon capture and next-generation sequencing and studying these genes in the pathogenesis of melanoma
- Understand the mechanisms of primary and acquired resistance to targeted therapies (including B-RAF inhibitors) using integrated genomic technologies
We are affiliated with the following departments at UCLA:
- Department of Medicine/Division of Dermatology
- Department of Molecular and Medical Pharmacology
- Jonsson Comprehensive Cancer Center (Tumor Cell Biology Program)
The ideal candidates must have experience with:
- RNA expression profiles (GO, GSEA, etc.)
- Genomic DNA copy number variation data
- Tools for handling large data sets
Interested individuals should have:
- Experience with analysis of highly parallel sequencing data: A plus, but may be acquired via training by our current postdoctoral fellow.
- Fluency in English and strong written and oral communication skills: Prerequisites
- Permanent U.S. residency or citizenship: Not required
- At least one first-authored publication in a peer-reviewed journal
Apply for Postdoctoral Fellowships at Roger S. Lo Laboratory
Interested individuals should forward a CV along with three letters of recommendation, one from the doctoral thesis advisor or current employer, to rlo@mednet.ucla.edu.
