The prevalence of obesity has risen to its highest levels in history. Obesity and its related comorbidities are the leading medical problems of developed countries worldwide. Unfortunately, there is a paucity of efficacious and easily adaptable treatment options to combat this growing epidemic. One reason is because research is still underway to help explain the pathogenesis of obesity. Recent evidence suggests a substantial role of the gut, its microbiome, and the brain in the development and progression of obesity. The brain gut microbiome system is this interconnected network between the brain and the gut microbiome and its related-metabolites and hormone signaling. Research has shown the brain gut microbiome system to be integral in the development of food addiction, weight gain, metabolism, nonalcoholic fatty liver disease, metabolic syndrome, and insulin resistance.
Experienced clinicians at UCLA Health have partnered with seasoned researchers to explore the field of the brain gut microbiome system and how it effects obesity and obesity related comorbidities. Research and clinical care is focused on helping patients have better understanding and control over their weight. Patients can be seen at the Center for Obesity and Metabolic Health (COMET). Patients are primarily seen in Westwood but also at the other UCLA Health outpatient GI clinics in the greater Los Angeles area including the West Los Angeles Veterans Affair Hospital System.