Esteve-Rudd J, Hazim RA, Diemer T, Paniagua AE, Volland S, Umapathy A, Williams DS: Defective phagosome motility and degradation in cell non-autonomous RPE pathogenesis of a dominant macular degeneration. Proceedings of the National Academy of Sciences, 115:5468-5473, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29735674PMID: 29735674
Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS:Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Research & Therapy. 8:217, 2017https://www.ncbi.nlm.nih.gov/pubmed/28969679PMID: 28969679
Volland S, Hughes LC, Kong C, Burgess BL, Linberg KA, Luna G, Zhou ZH, Fisher SK, and Williams DS: Three-dimensional organization of nascent rod outer segment disk membranes. Proceedings of the National Academy of Sciences112(48):14870-14875, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26578801PMID: 26578801
Jiang M, Esteve-Rudd J, Lopes VS, Diemer T, Lillo C, Rump A, Williams DS: Microtubule motors transport phagosomes in the RPE and lack of KLC1 leads to AMD-like pathogenesis. Journal of Cell Biology210(4):595-611, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26261180PMID: 26261180
Lopes VS, Boye SE, Louie CM, Boye S, Dyka F, Chiodo V, Fofo H, Hauswirth WW, Williams DS: Retinal gene therapy with a largeMYO7AcDNA using Adeno-associated virus. Gene Therapy20:824-833, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23344065PMID: 23344065
Trivedi D, Colin E, Louie CM, Williams DS: Live-cell imaging evidence for the ciliary transport of rod photoreceptor opsin by heterotrimeric kinesin-2. Journal of Neuroscience32:10587-10593, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22855808PMID: 22855808
Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS: The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Human Molecular Genetics20:2560-2570, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21493626PMID: 21493626
Lopes VS, Jimeno D, Khanobdee K, Song X, Chen B, Nusinowitz S, Williams DS: Dysfunction of Heterotrimeric Kinesin-2 in Rod Photoreceptor Cells and the Role of Opsin Mislocalization in Rapid Cell Death. Molecular Biology of the Cell21:4076-4088 (plus front cover), 2010. http://www.ncbi.nlm.nih.gov/pubmed/20926680PMID: 20926680
Louie CM, Caridi G, Lopes VS, Brancati F, Kispert A, Lancaster MA, Schlossman AM, Otto EA, Leitges M, Grone HJ, Lopez I, Gudiseva HV, O'Toole JF, Vallespin E, Ayyagari R, Ayuso C, Cremers FP, den Hollander Al, Koenekoop RK, Dallapiccola B, Ghiggeri GM, Hildebrandt F, Valente EM, Williams DS, Gleeson JG: AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nature Genetics42:175-180, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20081859PMID: 20081859
Schwander M, Lopes V, Sczaniecka A, Gibbs D, Lillo C, Delano D, Tarantino LM, Wiltshire T, Williams DS, Müller U: A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells. Journal of Neuroscience29:15810-15818, 2009. http://www.ncbi.nlm.nih.gov/pubmed/20016096PMID: 20016096
Yang Z*, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS*, Zhang, K*: Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. Journal of Clinical Investigation118:2908-2916, 2008. *Co-corresponding authors. http://www.ncbi.nlm.nih.gov/pubmed/18654668PMID: 18654668
Hashimoto T, Gibbs D, Lillo C, Azarian SM, Legacki E, Zhang X-M, Yang XJ, Williams DS: Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B. Gene Therapy14:584-594, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17268537PMID: 17268537
Karan G, Lillo C, Yang Z, Cameron J, Locke KG, Zhao Y, Thirumalaichary S, Li C, Birch DG, Vollmer-Sanar H, Williams DS*, Zhang K*: Lipofuscin accumulation, abnormal electrophysiology and photoreceptor degeneration in mutantELOVL4transgenic mice: a model for macular degeneration. Proceedings of the National Academy Sciences102:4164-4169, 2005. *Co-corresponding authors http://www.ncbi.nlm.nih.gov/pubmed/15749821PMID: 15749821
Gibbs D, Azarian SA, Lillo C, Klomp AEM, Kitamoto J, Steel KP, Libby RT, Williams DS: Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. Journal of Cell Science117:6473-6483, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15572405PMID: 15572405
Gibbs D, Kitamoto J, Williams DS: Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein. Proceedings of the National Academy Sciences100:6481-6486, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12743369PMID: 12743369
Marszalek JR, Liu X, Roberts E, Chui D, Marth J, Williams DS, Goldstein LSB: Genetic evidence for a kinesin-II mediated pathway for opsin and arrestin transport in mammalian photoreceptors. Cell102:175-187, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10943838PMID: 10943838
Liu X, Udovichenko, IP, Brown SDM, Steel KP, Williams DS: Myosin VIIa participates in opsin transport through the photoreceptor cilium. Journal of Neuroscience19:6267-6274, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10414956PMID: 10414956
Liu X, Ondek B, Williams DS: Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 mice. Nature Genetics19:117-118, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9620764PMID: 9620764
Arikawa K, Molday LL, Molday RS, Williams DS: Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration. Journal of Cell Biology116:659-667, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1730772PMID: 1730772
