Hepatology Group
- Steven-Huy B. Han, MD (Principal)
- Gina Choi, MD
- Francisco Durazo, MD
- Mohamed El Kabany, MD
- Sammy Saab, MD, MPH (scroll down for Dr. Saab's individual research)
- Myron Tong, MD, PhD
- Beshoy T. Yanny, MD
Funding
Current Research Projects
- NIH-funded DILIN (Drug-Induced Liver Injury Network)
- NIH-funded HBRN (Hepatitis B Research Network)
- NASH clinical trials
- Alcoholic hepatitis clinical trial
- Hepatitis B clinical trials
Future Research Directions
- Hepatitis B translational work
- NASH studies
- HCC studies
Current GI Research Fellows
- Ani Kardashian, MD
- Andrew Su, MD
Past GI Research Fellows
- Kelvin Nguyen, MD
- Jennifer Phan, MD
Sammy Saab, MD, MPH - Individual Research
Funding
Current Research Projects
- Elimination of hepatitis C
- Telemedicine: Effectiveness and patient satisfaction
- Survivorship and hepatocellular carcinoma
- Epidemiology of hepatitis C in Los Angeles
- Utility of hepatitis C positive grafts in hepatitis C negative recipients
Future Research Directions
- Liver transplantation
- Cirrhosis
- Chronic hepatitis C
- Quality of life and patient related outcomes
Key Publications (Partial List Including 2018 and 2017 Only)
- Saab S, Mehta D , Hudgens S, Grunow N, Bao Y , Brett Pinsky. Effect of ombitasvir/paritaprevir/ritonavir + dasabuvir regimen on health related quality of life for patients with hepatitis C. Liver International 2018;38(8):1377-1394.
- Saab S, Abbey B, Challita Y, Adeniyi A, Aziz A, Choi G, Durazo F, El-Kabany M, Han SH, Busuttil RW. Impact of Sustained Viral Response with Direct Acting Agents on Glycemic Control and Renal Function in Liver Transplant Recipients. Experimental Clin Transplant 2018;16:419-424.
- Chirikov VV, Marx SE, Manthena SR, Strezewski JP, Saab S. Development of a Comprehensive Dataset of Hepatitis C Patients and Examination of Disease Epidemiology in the United States, 2013–2016. Adv Ther 2108;35:1087-1102.
- Saab S, Challita. Y, Kahaleh M, Holloman D, Hathaway K, Nieto J. Case Series Review of the Safety and Efficacy of Endoscopic Ultrasound Guided Splenic Mass Core Biopsy. Clinical Endoscopy 2018 (in press).
- Saab S, Ahn T, McDaniel T, Yanny B, Tong, M. Economic Comparison of Serologic and Molecular Screening Strategies for Hepatitis C Virus. Gastroenterol Hepatol (N Y). August 2018 - Volume 14, Issue 8 (in press).
- Saab S, Le Long, Saggi S, Sundaram V, Tong M. Toward the Elimination of Hepatitis C in the United States. Hepatology 2018 (in press).
- Yanny B, Latt N, Saab S, Han S, Choi G, Kramer J, Sahota A. Risk of Hepatitis B Virus Reactivation Among Patients Treated with Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection. J Clin Gastroenterology 2018 (in press).
- Saab S, Youssef C, Chen PH, Jimenez MA, Lee AD, Saab EG, Ahn T, Choi G, Durazo F, El-Kabany M, Han SH, Grotts J, Agopian VG, Busuttil RW. The Elimination of Hepatitis C in Liver Transplant Recipients. J Clin Transl Hepatol. 2018 (in press).
- Aby E, Phan J. Troung E. Grotts J, Saab S. Inadequate Hepatocellular Carcinoma Screening in patients with Non-Alcoholic Steatohepatitis Cirrhosis. J Clin Gastroenterol 2018 (in press).
- Reardon LC, DePasquale EC, Tarabay J, Cruz D, Laks H, Biniwale RM, Busuttil RW, Kaldas FM, Saab S, Venick RS, Lin JP, Nsair A, Deng MC, Ardehali A, Caderias M, Iygengar A, Aboulhosn JA. Heart and heart-liver transplantation in adults with failing Fontan physiology. Clin Transplant. 2018 (in press)
- Phan J, Ng V, Sheinbaum A, French S, Choi G, El Kabany M, Durazo F, Saab S, Tong M, Busuttil R, Han SH. Hyperlipidemia and Nonalcoholic Steatohepatitis Predispose to Hepatocellular Carcinoma Development Without Cirrhosis. J Clin Gastroenterol. 2018 (in press).
- Lee EW, Saab S, Kaldas F, Fletcher S, Busuttil RW, Durazo F, McWilliams JP, DiNorcia J 3rd, Padia SA, Kee ST. Coil-Assisted Retrograde Transvenous Obliteration (CARTO): An Alternative Treatment Option for Refractory Hepatic Encephalopathy. Am J Gastroenterol. 2018 (in press).
- Aby E, Lee E, Saggi SS, Viramntes MR, Grottss JF, Agopian A, Busuttil RW, Saab S. Pre-Transplant Sarcopenia in Patients with NASH Cirrhosis Does Not Impact Re-hospitalization or Mortality. J Clin Gastroenterology 2018 (in press).
- Sikavi C, Najarian L, Saab S. Similar Sustained Virologic Response in Real-World and Clinical Trial Studies of Hepatitis C/Human Immunodeficiency Virus Co-Infection. Dig Dis Sci 2018 (in press)
- Saab S, Kardashian A, Saggi S, Choi G, Agopian A, Tong MJ. Use of Hepatitis C Positive Grafts in Hepatitis C Negative Liver Transplant Recipients is Cost-Effective. Clinical Transplantation 2018 (in press).
- Saab S, Viramontes, MR, Chalifoux SL, Craw CJ, Ramirez SD, Bau SN, Arevalo DG, Saab EG, Saab CM, Craw CS, Estafanous A, Messiah R, Messiah W, El Kabany M. Hepatitis C Virus Prevalence in Egyptian-Americans in Southern California. J Clin Gastroenterol 2018;52:55-59.
- Nieto J, Khaleel H, Challita Y, Jimenez M, Baron TH, Walters L, Hathaway K, Patel K, Lankarani A, Herman M, Holloman, D, Saab S. Endoscopic Ultrasound guided Fine Needle Core Liver Biopsy Using a Novel 19 Gauge Needle with Modified One Pass One Actuation Wet Suction Technique. Gastrointestinal Endoscopy. 2018;87:469-475
- Abaalkhail F, Elsiesy H, Elbeshbeshy H, Shawkat M, Yousif S, Ullah W, Alabbad S, Al-Jedai A, Ajlan A, Broering D, Saab S, Al Sebayel M, Al-Hamoudi W. Treatment of Patients With Hepatitis C Virus infection (Genotype 4) With Ledipasvir-Sofosbuvir in the Liver Transplant Setting. Transplantation. 2017;101:2739-2745
- Younossi ZM, Park H, Dieterich D, Saab S, Ahmed A, Gordon SC. The Value of Cure Associated with Treating Treatment-naive Chronic Hepatitis C Genotype 1: Are the New All Oral Regimens Good Value to Society? Liver Int. 2017;37:662-668.
- Sikavi C, Chen PH, Lee A, Saab EG, Choi G, Saab S. Hepatitis C and Human Immunodeficiency Virus Co-Infection in the Era of Direct-Acting Antiviral Agents: No Longer A Difficult to Treat Population. Hepatology 2018;67:847-857.
- Suraweera D, Fanous C, Jimenez M, Tong MJ, Saab S. Risk of Cardiovascular Events in Patients with Primary Biliary Cholangitis ~ Systematic Review. J Clin Transl Hepatol 2018;6:119-126
- Corson M, Moch A, Saab S. Hepatitis C Virus Treatment in Patients with Chronic Kidney Disease and in Kidney Transplant Recipients. Gastroenterol Hepatol (N Y). 2018;14:280-285
- Hanna RM, So N, Kaldas M, Hou J, Arman F, Sangalang M, Yanny B, Selamet U, Saab S, Nobakht N, Rastogi A. Case Report: Patient with Hepatitis C, p-ANCA, and Cryoglobulin Antibodies Presenting with Necrotizing Crescentic p-ANCA Glomerulonephritis. Case Rep Nephrol Dial 2018;8:161-170
- Younossi ZM, Gordon SC, Ahmed A, Dieterich D, Saab S, Beckerman R. Treating Medicaid Patients with Hepatitis C: Clinical and Economic Impact. A J Managed Care. 2017;23:294-299.
- Nguyen K, Jimenez M, Moghadam N, Wu C, Farid A, Grotts J, Elashoff D, Choi G, Durazo FA, El-Kabany MM, Han SHB, Saab S. Decrease of Alpha-Fetoprotein in Patients with Cirrhosis Treated with Direct Acting Agents. Journal of Clinical and Translational Hepatology 2017;5:43-49.
- Patel AA, Walling AM, May FP, Saab S, Wenger N. Palliative Care and Healthcare Utilization for Patients with End-Stage Liver Disease at the End of Life. Clin Gastroenterol Hepatol. 2017.
- Lin TY, Shekar AO, Li N, Yeh MW, Saab S, Wilson M, Leung AM Incidence of Abnormal Liver Biochemical Tests in Hyperthyroidism Clin Endocrinol (Oxf). 2017; 86(5):755-759.
- Saab S, Viramontes, MR, Chalifoux SL, Craw CJ, Ramirez SD, Bau SN, Arevalo DG, Saab EG, Saab CM, Craw CS, Estafanous A, Messiah R, Messiah W, El Kabany M. Hepatitis C Virus Prevalence in Egyptian-Americans in Southern California. J Clin Gastroenterol 2017.
- Ahmed A, Gonzalez SA, Cholankeril G, Perumpail RB, McGinnis J, Saab S, Beckerman R, Younossi ZM. Treatment of Patients Waitlisted for Liver Transplant with an All-Oral DAAs is a Cost-Effective Treatment Strategy in the United States. Hepatology 2017;66(1):46-56.
- Younossi Z, Gordon SC, Ahmed A, Dieterich D, Saab S, Beckerman R. Treating Medicaid patients with hepatitis C: clinical and economic impact. Am J Manag Care. 2017;23:107-112.
- Saab S, Rheem J, Jimenez MA, Fong TM, Mai MM, Kachardoorian CA, Esmilzadeh NL, Bau SN, Kang S, Ramirez SD, Grotts, Choi G, Durazo FA, El-Kabany MM, Han SHB, Busuttil RW. Effectiveness of Ledipasvir/Sofosbuvir with/without Ribavirin in Liver Transplant Recipients with Hepatitis C. J Clin Transl Hepatol 2017;5(2):101-108.
- Saab S, Phan J, Jimenez M, Grotts J, Walters L, Hathaway K, Patel K, Lankarani A, Herman M, Holloman D, Nieto J. Endoscopic Ultrasound Liver Biopsies Accurately Predict the Presence of Fibrosis in Patients with Fatty Liver. Clinical Gastroenterology and Hepatology 2017.
- Elrazek A, Saab S, Foad M, Elgohary EA, Sallam MM, Nawara A, Ismael A, et al. Ongoing transmission of HCV: Should cesarean section be justified? Data mining discovery. J Transl Int Med. 2017;5:27-33.
- Stepanova M, Clement S, Wong R, Saab S, Ahmed A, Younossi ZM. Patients with Diabetes and Chronic Liver Disease are at Increased Risk for Overall Mortality: A Population Study from the United States. Clinical Diabetes 2017;35: 79-83.
- Aby E, Jimenez MA, Grotts JF, Agopian V French SW, Busuttil RW, Saab S. Diminishing Role of Liver Biopsy for Hepatitis C in Liver Transplant Recipients. J Clin Transl Hepatol 2017.
- Tavakoli H, Robinson A, Liu B, Bhuket T, Younossi Z, Saab S, Ahmed A, Wong RJ. Cirrhosis Patients with Nonalcoholic Steatohepatitis Are Significantly Less Likely to Receive Surveillance for Hepatocellular Carcinoma. Dig Dis Sci. 2017.
- Nieto J, Khaleel H, Challita Y, Jimenez M, Baron TH, Walters L, Hathaway K, Patel K, Lankarani A, Herman M, Holloman, D, Saab S. Endoscopic Ultrasound guided Fine Needle Core Liver Biopsy using a Novel 19 Gauge Needle with Modified One Pass One Actuation Wet Suction Technique. Gastrointestinal Endoscopy. 2017.
- Castrejón M, Chew KW, Javanbakht M, Humphries R, Saab S, Klausner JD. Implementation of a Large System-Wide Hepatitis C Virus Screening and Linkage to Care Program for Baby Boomers. Open Forum Infect Dis. 2017;4(3):ofx109. doi: 10.1093/ofid/ofx109.
Past GI Research Fellows
- Kelvin Nguyen, MD (2017-18)
- Tyralee Goo, MD (2014-15)
- Victoria Sheen, MD (2014-15)
- Gina Choi, MD (2013-14)
- Justin Reynolds, MD (2012-13)
- Vivian Ng, MD (2012-13)
- Jennifer Tan, MD (2007-09)
- Lenna Martyak, MD (2007-08)
- Carmen Landaverde, MD (2007-09)
- Andrew Kim, MD (2006-07)
- Jose Nieto, DO (2004-06)
- Shiobhan Weston, MD (2002-03)
Current GI Research Fellows
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