Prevention and early treatment of acute lung injury (PETAL) network. PETAL network website

The PETAL Network is a multicenter network funded by the National Heart, Lung, and Blood Institute (NHLBI) to develop and conduct randomized controlled clinical trials to prevent or treat, and/or improve the outcome of patients who have, or who are at risk for, Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS).

Studies include:

  • Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study (BLUE CORAL) - this study aims to identify acute and critically ill COVID-19 patients and collect detailed data during and after hospitalization in order to increase understanding of COVID-19 (actively enrolling).

  • PETAL Repository of Electronic Data COVID-19 Observational Study (RED CORAL) - this study aims to identify acute and critically ill patients with COVID-19 and collect detailed data from their hospital stay in order to advance United States participation in studies of global epidemiology and increase understanding of the clinical course of COVID-19 (completed enrollment).

  • Outcomes Related to COVID-19 Treated with Hydroxychloroquine among In-patients with Symptomatic Disease (ORCHID) - a clinical trial to evaluate the safety and effectiveness of hydroxychloroquine for the treatment of adults hospitalized with COVID-19 (no longer enrollling). Learn more

  • Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) - a prospective study comparing early vasoactive support + conservative fluids to liberal fluids for septic shock (actively enrolling)

  • Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery (ASTER) - this trial assesses the efficacy of intravenous acetaminophen and vitamin C in improving the outcomes of patients with sepsis and either hemodynamic or respiratory organ failure. This study is anticipated to start in the near future

  • Reevaluation of Early Neuromuscular Blockade (ROSE) - a study that evaluated the role of neuromuscular blockade in moderate-to-severe ARDS when compared to light sedation/daily awakenings (completed enrollment). Read full article

  • Vitamin D to Improve Outcomes by Levering Early Treatment (VIOLET) - this study examined whether or not high-dose Vitamin D can prevent ARDS in patients with risk factors for ARDS with intent to admit to the ICU (completed enrollment). Read full article

  • Low Tidal Volume Universal Support: Feasibility of Recruitment for Interventional Trial (LOTUS-FRUIT) - this study observed patients with acute respiratory failure to assess the feasibility of a pragmatic trial of low tidal volume ventilation (completed enrollment). Read full article