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• Diabetes

  Diagnosing Diabetes

  According to the National Institute of Diabetes and Digestive and Kidney Diseases: People over age 45 should be tested for prediabetes or diabetes. If the first blood glucose test is normal, they should be retested every 3 years. If you are younger, you should be tested if you are at high risk.
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1. Goland R*, Freeby M*, Parsey R*, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei M, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE. 11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls. J Nuclear Medicine. 2009, 50(3): 382-389.
2. Stein EM, Cohen A, Freeby M, Rogers H, Kokolus S, Scott V, Mancini D, Restaino S, Brown R, McMahon DJ, Shane E. Severe vitamin D deficiency among heart and liver transplant recipients. Clinical Transplantation. April 2009. 23(6): 861-
3. Inabnet WB, Milone L, Harris P, Durak E, Freeby MJ, Ahmed L, Sebastien M, Lifante JC, Bessler M, Korner J. The Utility of 11C dihydrotetrabenazine positron emission tomography scanning in assessing beta-cell performance after sleeve gastrectomy and duodenal-jejunal bypass. Surgery. 2010, 147(2): 303-309.
4. Noggle S, Fung HL, Gore A, Martinez H, Satriani KC, Prosser R, Oum K, Paull D, Druckenmiller S, Freeby M, Greenberg E, Zhang K, Goland R, Sauer MV, Leibel RL, Egli D. Human Oocytes Reprogram Somatic Cells to a Pluripotent State. Nature. 2011, 478(7367):70-5.
5. Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R, Harris P. Dopamine Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion In Vitro. Molecular Endocrinology. 2012, 26(10):1757-72.
6. Freeby M, Ichise M, Harris P. Vesicular Monoamine Transporter, type 2 (VMAT2) Expression as it Compares to Insulin and Pancreatic Polypeptide in the Head, Body and Tail of the Human Pancreas. Islets. 2012, 4(6):1-5.
7. Hua H, Shang L, Martinez H, Freeby M, Gallagher MP, Ludwig T, Deng L, Greenberg E, LeDuc C, Chung W, Goland R, Leibel R, Egli D. iPSC-Derived β Cells Model Diabetes due to Glucokinase Deficiency. Journal of Clinical Investigation. 2013, 123(7):3146-53.
8. Shang L Hua H, Foo K, Martinez H, Watanabe K, Zimmer M, Kahler D, Freeby M, Chung W, LeDuc C, Goland R, Leibel R, Egli D. Beta Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome. Diabetes. 2014, 63(3):923-33.
9. Yamada M, Johannesson B, Sagi I, Burnett LC, Kort DH, Prosser RW, Paull D, Nestor M, Freeby M, Greenberg E, Goland RS, Leibel RL, Solomon SL, Benvenisty N, Sauer MV, Egli D. Human Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Puripotent Stem Cells. Nature. 2014, 510(7506):533-6.
10. Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest. 2015, 125(2):796-808.
11. Freeby MJ, Kringas P, Goland RS, Leibel RL, Maffei A, Divgi C, Ichise M, Harris PE. Cross-Sectional Test-Retest Characterization of PET with [18F]-FP-+-DTBZ for β Cell Mass Estimates in Diabetes. Molecular Imaging Biology. September, 2015.

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