History of Celiac Disease

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2nd Century AD

Aretaeus of Cappodocia, a Greek physician, describes a malabsorptive diarrhea affecting children.


Samuel Gee, an English pediatrician, describes children who suffer from chronic indigestion and wasting and reports that the cure for this condition would be through diet.



Sidney Haas, an American pediatrician, determines that carbohydrates are the culprit food in celiac disease and treats 10 children with a "banana diet."


William Dicke, a Dutch pediatrician, notes that during World War II children with celiac disease improve when they lack access to wheat, further strengthening the relationship between wheat ingestion and celiac disease.



Margot Shiner, a pediatric gastroenterologist, develops a biopsy technique to examine the small intestine and observe the pathologic changes in celiac disease.


The anti-gliadin antibody was discovered.


Celiac disease associated with other autoimmune diseases

  • Thyroid
  • Diabetes
  • Down's syndrome


The genetic markers HLA-DQ2 and HLA-DQ8 are identified and the anti-transglutaminase antibodies are identified.