The goal of this proposal is to demonstrate the safety, feasibility and preliminary efficacy of deep brain stimulation (DBS) of the subgenual cingulate cortex (SCC) region in the treatment of medically refractory chronic low back pain (CLBP).
The overall goal of this research is to identify the electrophysiological and neuroanatomical correlates of motivation and hedonic value within the basal ganglia and limbic system. This will better inform future therapeutic interventions for the treatment of addiction and other neuropsychiatric disorders.
This study examines whether non-invasively stimulating of the vagus nerve can modulate complex behaviors upstream of the site of stimulation. This research grants us the opportunity to develop future non-invasive therapeutic interventions for the treatment of impulse control disorders.
The proposed research aims to delineate the role of the basal ganglia and limbic system in mediating brain reward and motivation. This knowledge will result in a better understanding of the neurobiology of substance abuse and help to develop novel treatment strategies.