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Caroline Y. Kuo, MD

Pediatric Allergy and Immunology
Primary Location
Childrens Health Center
200 Medical Plaza
265
Los Angeles, California 90095
Phone
Fax
310-825-9832

About

Dr. Caroline Kuo is an Assistant Professor of Pediatrics in the Division of Allergy, Immunology, and Rheumatology at UCLA. She attended medical school at the Keck School of Medicine at USC, completed her pediatrics residency at Harbor-UCLA, Allergy & Immunology fellowship at UCLA, and is board-certified in Allergy & Immunology.

Dr. Kuo's clinical practice focuses on the diagnosis and treatment of both pediatric and adult patients with immunodeficiencies and recurrent infections. For more than forty years, the Division has provided clinical care to patients with primary immune deficiencies and has made seminal contributions to improving the treatment of individuals with these disorders. In recognition of these efforts, the Division has been named a Center of Excellence for the Diagnosis and Treatment of Primary Immunodeficiency by the Jeffrey Modell Foundation.

Dr. Kuo's research investigates novel therapies for rare immunologic diseases, and her work has been funded by the UCLA Children's Discovery and Innovation Institute, Primary Immune Deficiency Treatment Consortium, Clinical Immunology Society, NIH CHRC, the Hyper-IgM Foundation, and the California Institute for Regenerative Medicine (CIRM) amongst others. She currently serves as the UCLA Site Principal Investigator for a Phase I/II clinical trial for patients with X-Linked Chronic Granulomatous Disease funded by CIRM and is an investigator on other gene therapy trials for primary immune deficiencies at UCLA.

Clinical Interest

  • Immune Deficiencies in pediatric and adult patients
  • Recurrent/frequent infections in pediatric and adult patients
  • Genetic diagnosis of immune deficiencies for pediatric and adult patients
  • Immune globulin replacement for pediatric and adult patients with immunodeficiency
  • 22q11 deletion syndrome (also called DiGeorge Syndrome)

Education

Medical Board Certifications

Allergy and Immunology, American Board of Allergy and Immunology, 2014
Pediatrics, American Board of Pediatrics, 2010

Fellowship

UCLA School of Medicine, 2014
Harbor - UCLA Medical Center, 2011

Residency

Harbor - UCLA Medical Center, 2010

Internship

Harbor - UCLA Medical Center, 2008

Degree

Keck School of Medicine of USC, MD, 2007

Hospital Affiliations

Research

Interests

  • Immune Deficiencies
  • Gene Therapy

Publications

  1. Kuo C, Chase J, Garcia-Lloret M, Stiehm ER, et al. Newborn Screening for Severe Combined Immunodeficiency Does Not Identify Bare Lymphocyte Syndrome. J Allergy Clin Immunol. 131(6); 1693-1695. 2013
  2. Kuo C, Thakor A, Braskett M. Primary Immunodeficiency Diseases (PIDD) in the Adult Population. ACP Hospitalist. 2014 Oct.
  3. Kubiak C, Jyonouchi S, Kuo C, Garcia-Lloret M, Dorsey M, Sleaseman J, Zbrozek A, Perez E. Fiscal Implications of Newborn Screening in the Diagnosis of Severe Combined Immunodeficiency. J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):697-702.
  4. Tseng M, Ge S, Roberts R, Kuo C, et al. Liver Transplantation in a Patient with CD40 Ligand Deficiency and Hyper-IgM Syndrome: Clinical and Immunological Assessments. American Journal of Transplantation. 2016 May;16(5):1626-1632.
  5. Kuo CY and Kohn DB. Gene Therapy for the Treatment of Primary Immune Deficiencies. Curr Allergy Asthma Rep. 2016 May;16(5):39.
  6. Hoban MD, Lumaquin DL, Kuo CY, et al. CRISPR/Cas9-mediated correction of the sickle mutation in human hematopoietic stem-progenitor cells. Mol Ther. 2016 Apr 23;125(17):2597-604.
  7. Bjurstrom CF, Mojadidi M, Phillips J, Kuo C, et al. Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts through BCL11A Knockdown Using Targeted Endonucleases. Mol Ther Nucleic Acids. Epub ahead of print August 2016.
  8. de la Morena MT…Kuo CY, et al. Long term outcomes of 176 patients with X-linked hyper IgM syndrome treated with or without hematopoietic cell transplantation. J Allergy Clin Immunol. Accepted August 2016.
  9. Kuo CY, Garcia-Lloret MI, Slev P, Bohnsack JF, Chen K. Profound T-cell Lymphopenia Associated with Prenatal Exposure to Purine Antagonists Detected by TREC Newborn Screening. J Allergy Clin Immunol Pract. Accepted September 2016.

Awards

  • Super Doctors® Southern California Rising Stars 2020
  • Super Doctors® Southern California Rising Stars 2019