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The Cutting Edge

Modified Blood Test Could Help Predict Pregnancy Complications

Modified Blood Test Could Help Predict Pregnancy Complications

MRI of study participant’s baby at 21 weeks (left), and study participant with child. Images: Courtesy of Precious Ann Fortes

A new UCLA study is harnessing the power of molecular changes during pregnancy in a way that could help to more accurately predict such complications as gestational diabetes and preeclampsia before symptoms arise. In modifying a blood test used to detect DNA-level changes that could point to fetal abnormalities, this research is the first to tie potential pregnancy complications to the presence of cell-free nucleic acids — free-standing genetic material — shed from the placenta into the mother’s blood.

To Sherin U. Devaskar, MD, physician-in-chief at UCLA Mattel Children’s Hospital, this blood test is the first step in addressing at-risk pregnancies. “Most often in medicine, we’re fixing a problem after it occurs,” Dr. Devaskar says. “If we are able to detect some of these pregnancy disorders before they happen, and if we can prevent them, that will be phenomenal.”

To isolate cell-free nucleic acids shed from the placenta into the blood, the interdisciplinary team used state-of-the-art imaging, mathematical algorithms and modeling. Between February 2017 and January 2019, the researchers periodically tested the blood of a group of expectant mothers through the duration of their pregnancies. Giorgia Del Vecchio, PhD, a post-doctoral researcher in the UCLA Department of Pediatrics, analyzed the cell-free DNA from samples of maternal plasma taken during the first, second and third trimesters of pregnancy, and also at delivery. “We found that in patients who developed gestational diabetes later in pregnancy, the percentage of DNA coming from the placenta in the first trimester was higher compared to the patients with pregnancies that didn’t have complications,” Dr. Del Vecchio says.

The disorder typically is diagnosed with a glucose-tolerance test at 24-to-28 weeks, but with the blood test developed by UCLA researchers, it is detectable during the first trimester, between 10 and 12 weeks. The research team also was able to develop a model to predict preeclampsia with up to 86% accuracy by isolating and sequencing cell-free RNA to identify whether certain preeclampsia-indicating genes were at play.

New information paired with early detection will lead to better outcomes for mothers and their babies, Dr. Devaskar says. Mothers will be forewarned and, therefore, better able to work with their doctors on making the necessary diet, medical and behavioral changes to stave off pregnancy-related complications. “Knowledge is power,” she says. “And patients have the right to knowledge and to be powerful in their own care.”

— Jocelyn Apodaca Schlossberg

“Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes,” Epigenetics, October 13, 2020


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IN THIS ISSUE
  • Now Is the Time
  • The Day the Vaccine Arrived
  • The Art of Sport
  • How Babies Rewire Their Brains to See in 3-D
  • A Step Toward Understanding Why COVID-19 Boosts Stroke Risk
  • Study Finds More Americans Involuntarily Detained Due to Mental Illness
  • Study Illuminates Impact of COVID-19 on Pregnant Women
  • Into the Unknown
  • Fine Family Establishes Endowed Chair in UCLA Department of Surgery
  • A Final Hug with “Mi Amor”
  • Reclaiming Her Voice with a Gift of New Lungs
  • The Impact of Poverty on Childhood Development Noted in Kids as Young as 5
  • Virus-mimicking Drug Helps Immune System Target Cunning Cancer Cells
  • How To Build A Vaccine
  • The Reckoning
  • “This Is Our Moment”
  • Awards and Honors
  • In Memoriam
  • UCLA Health Expresses Gratitude for Board of Advisors Leadership
  • Games, Special Guests and Music Highlight UCLA’s Virtual Party on the Pier
  • Family Establishes Endowed Chair to Memorialize their Daughter
  • In the Quiet of the Holiday Season, the City of Angels Burns
  • A Watershed Moment
  • Race, Racism and Patient Care
  • Modified Blood Test Could Help Predict Pregnancy Complications
  • Into the Woods
  • Annual Tour de Pier Stages a Successful Virtual Event
  • Dr. Jessica Rexach Honored with Endowed Chair
  • Gifts
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