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• Bladder Cancer

  Bladder Cancer: Introduction

  The bladder is a hollow organ in the lower pelvis. The bladder wall is made up of many layers of cells. It has an outer layer of muscle cells, and an inner lining layer of other kinds of cells. Bladder cancer can affect any one or all of these cells. 
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• Oncology

  Cancer Overview

  Cancer cells don't function properly, and they can spread to many areas of the body. Tumors are clusters of cells that are capable of growing and dividing uncontrollably; their growth is not regulated.
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• Prostate Cancer

  Prostate Cancer: Introduction

  Prostate cancer is the most common cancer in men (not counting skin cancer) in the U.S. It tends to occur mainly in older men. In most cases prostate cancer is found before it has spread to other parts of the body. Cancer that hasn’t spread is easier to treat and cure.
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• Prostate Cancer-Metastasis

  Prostate Cancer: Grade and Stage

  Grade is a way to note how abnormal the cancer cells look under a microscope. Staging of cancer is a method of noting the extent of the cancer. The stage tells how big the cancer is, and if it has spread. Grade and stage are determined when a biopsy (tissue sample) and other tests are done on the cancer. 
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Areas of Research Interest:

• Prostate stem cells and development
  
• Epithelial-mesenchymal interactions in the prostate
  
• Functional biomarkers of prostate cancer progression and metastasis
  
• Prostate cancer health disparities
  
• Prostate cancer biorepositories
  
• Multi-omic platform analysis of lethal prostate cancer
  
• Digital image analysis applications in prostate cancer
  
• Single cell sequencing of prostate tumor populations

1. Miller, EM, Chamie, K, Kwan, L, Lewis, M, Knudsen, BS, and Garraway, IP*. Impact of treatment on progression to castration-resistance, metastases, and death in men with localized high-grade prostate cancer. October, 2016, Cancer Medicine, PMID: 27997745; PMCID: PMC5269571.
   
2. Brennen, NW, Zhang, B, Kulac, I, Kisteman, N, Antony, L, Wang, H, DeMarzo, AM, Garraway, IP, Denmeade, SR, and Isaacs, JT. Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate. July 18, 2017, Oncotarget, PMID 28493842; PMCID: PMCID: 5564518.
   
3. Malihi, PD, Morikado, M, Welter, L, Liu, ST, Miller, ET, Cadaneanu, RM, Knudsen, BS, Lewis, MS, Carlsson, A, Velasco, CR, Kolatkar, A, Lee, MR, Garraway, IP, Hicks, J, and Kuhn, P. Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis. Converg Sci Phys Oncol 2018;4:015003.PMID: 32670616
   
4. Rotinen, M, You, S, Yang, J, Coetzee, S, Huang, W-C, Huang, F, Pan, X, Yanez, A, Hazelett, D, Chu, C-Y, Chung, L, Freedland, S, DiVizio, D, Garraway, I, Murali, R, Knudsen, B, and Freeman, M. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Submitted to Nature Medicine, Nov. 26, 2018. PMID: 30478421
   
5. Parikh NR, Huiza C, Patel JS, Tsai S, Kalpage N, Thein M, Pitcher S, Lee SP, Inouye WS, Jordan ML, Sanati H, Jafari L, Bennett CJ, Gin GE, Kishan AU, Reiter RE, Lewis M, Sadeghi A, Aronson WJ, Garraway IP, Rettig MB, Nickols NG. Systemic and tumor-directed therapy for oligometastatic prostate cancer: study protocol for a phase II trial for veterans with de novo oligometastatic disease. BMC Cancer. 2019 Apr 1;19(1):291. doi: 10.1186/s12885-019-5496-5.PMID: 30935383
   
6. Jan YJ, Yoon J, Chen JF, Teng PC, Yao N, Cheng S, Lozano A, Chu GCY, Chung H, Lu YT, Chen PJ, Wang JJ, Lee YT, Kim M, Zhu Y, Knudsen BS, Feng FY, Garraway IP, Gao AC, Chung LWK, Freeman MR, You S, Tseng HR, Posadas EM. A circulating tumor cell-RNA assay for assessment of androgen receptorsignaling inhibitor sensitivity in metastatic castration-resistant prostate cancer. Theranostics. 2019 Apr 13;9(10):2812-2826. doi: 10.7150/thno.34485. eCollection 2019.PMID: 31244925
   
7. Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ. Asporin Restricts Mesenchymal Stromal Cell Differentiation and Drives Metastatic Progression. Cancer Res. 2019 Jul 15;79(14):3636-3650. doi: 10.1158/0008-5472.CAN-18-2931. Epub 2019 May 23. PMID: 31123087
   
8. Miller ET, You S, Cadaneanu RM, Kim M, Yoon J, Liu ST, Li X, Kwan L, Hodge J, Quist MJ, Grasso CS, Lewis MS, Knudsen BS, Freeman MR, Garraway IP. Chromosomal instability in untreated prostate cancer as an indicator of metastatic potential. BMC Cancer. 2020 May 7;20(1):398. doi: 10.1186/s12885-020-06817-1.PMID: 32380981
   
9. Kishan AU, Romero T, Alshalalfa M, Liu Y, Tran PT, Nickols NG, Ye H, Sajed D, Rettig MB, Reiter RE, Garraway IP, Spratt DE, Freedland SJ, Zhao X, Li Z, Deek M, Livingstone J, Mahal BA, Nguyen PL, Feng FY, Den RB, Schaeffer EM, Lotan TL, Karnes RJ, Klein EA, Ross AE, Grogan T, Davicioni E, Elashoff D, Boutros PC, Weidhaas JB. Transcriptomic heterogeneity of Gleason grade group 5 prostate cancer. Eur Urol. 2020 May 24: S0302-2838(20)30349-3. doi: 10.1016/j.eururo.2020.05.009. Online ahead of print.PMID: 32461072
   
10. Lec PM, Lenis AT, Golla V, Brisbane W, Shuch B, Garraway I, Reiter R, Chamie KJ. The role of opoids and their receptors in urologic malignancy: a review. J Urol. 2020 Jun 9:101097JU0000000000001156. doi: 10.1097/JU.0000000000001156. Online ahead of print.PMID: 32516030

• 2018 Los Angeles Magazine Top Doctors
• Guy Dalla Riva Award 2004
• American Society of Clinical Investigators Outstanding Research Award 2004
• Miley B. Wesson Proctor & Gamble Resident Award Winner, Western Section, AUA 2003
• Los Angeles Urological Resident Award Winner 2003

Recent Grants:

• UCLA SPORE in Prostate Cancer (co-Investigator)
• Prostate Cancer Foundation Challenge Award (Principal Investigator)
• Department of Defense Prostate Cancer Research Program Idea Award (co-Investigator)